Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Hui-Ju Tseng"'
Autor:
Jung-Chun Chu, Hui-Ju Tseng, Sung-Bau Lee, Kai-Cheng Hsu, Ling-Wei Hsin, Ru-Hao Liang, Tony Eight Lin, Nain-Chu Gao, Liang-Chieh Chen, Wan-Hsun Lu, Andrew H.-J Wang, Wei-Jan Huang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Class II histone deacetylases (HDACs) are considered as potential targets to treat Alzheimer’s disease (AD). Previously, C-3 substituted phenothiazine-containing compounds with class II HDAC-inhibiting activities was found to promote neurite outgro
Externí odkaz:
https://doaj.org/article/7b58580986544041963eeb2da4256825
Autor:
Jui-Yi Hsu, Kai-Cheng Hsu, Ching Sun, Ching-Hsuan Chou, Tony Eight Lin, Tzu-Ying Sung, Hui-Ju Tseng, Shih-Chung Yen, Chia-Ron Yang, Wei-Jan Huang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114258- (2023)
Cyclin-dependent protein kinase 8 (CDK8) plays important roles in regulating fibrotic growth factors and inflammatory signaling pathways. Long-term chronic inflammation of the lungs can lead to idiopathic pulmonary fibrosis (IPF). Abnormal alveolar e
Externí odkaz:
https://doaj.org/article/69ee12bcfc574e07acf7e07b3ddb8146
Autor:
Kai-Cheng Hsu, Chang-Yi Liu, Tony Eight Lin, Jui-Hua Hsieh, Tzu-Ying Sung, Hui-Ju Tseng, Jinn-Moon Yang, Wei-Jan Huang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Histone deacetylases (HDAC) contain eighteen isoforms that can be divided into four classes. Of these isoform enzymes, class IIa (containing HDAC4, 5, 7 and 9) target unique substrates, some of which are client proteins associated with epige
Externí odkaz:
https://doaj.org/article/7b99dbc22d7541d3950827cebd4867ae
Autor:
Hui-Ju Tseng, Wen-Chu Chen, Tien-Fen Kuo, Greta Yang, Ching-Shan Feng, Hui-Ming Chen, Tzung-Yan Chen, Tsung-Han Lee, Wen-Chin Yang, Keng-Chang Tsai, Wei-Jan Huang
Publikováno v:
Cellular and Molecular Life Sciences. 80
Pdia4 has been characterized as a key protein that positively regulates β-cell failure and diabetes via ROS regulation. Here, we investigated the function and mechanism of PS1, a Pdia4 inhibitor, in β-cells and diabetes. We found that PS1 had an IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e371fd4aff57e8a3539f8bef49dadb92
https://doi.org/10.1007/s00018-022-04677-5
https://doi.org/10.1007/s00018-022-04677-5
Autor:
Shivani Soni, Hui Ju Tseng, Yan Yang, Goar Smbatayan, Unnati Hemant Shah, Jae Ho Lo, Joshua Millstein, Francesca Battaglin, Pooja Mittal, Lesly Torres Gonzalez, Wu Zhang, Jean Chen Shih, Heinz Josef Lenz
Publikováno v:
Cancer Research. 83:4671-4671
Background: Mitochondrial MAO A and MAO B isoenzymes catalyze oxidative deamination of neuroactive and vasoactive monoamines in CNS and peripheral tissues. MAO A inhibitors have been used as antidepressants; MAO B inhibitors have been used for Parkin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ed0def29440b82979c13880ff92f7ab
https://doi.org/10.1158/1538-7445.am2023-4671
https://doi.org/10.1158/1538-7445.am2023-4671
Autor:
Liang-Chieh Chen, Hui-Ju Tseng, Chang-Yi Liu, Yun-Yi Huang, Cheng-Chung Yen, Jing-Ru Weng, Yeh-Lin Lu, Wen-Chi Hou, Tony E. Lin, I-Horng Pan, Kuo-Kuei Huang, Wei-Jan Huang, Kai-Cheng Hsu
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with multiple etiologies. Beta-amyloid (Aβ) self-aggregation and overexpression of class IIa histone deacetylases (HDACs) are strongly implicated with AD pathogenesis. In this st
Externí odkaz:
https://doaj.org/article/326b205065db448eb7092655b9cef6a2
Autor:
Jui Yi Hsu, Hui Ju Tseng, Cheng Chung Yen, Hui Kang Liu, Wei Jan Huang, Kun Chang Wu, Kai Cheng Hsu, Ashish Rao Sathyan, Liang Chieh Chen
Publikováno v:
Journal of Natural Products. 84:1096-1103
Type 2 diabetes mellitus (T2DM) is associated with pancreatic β-cell dysfunction and insulin resistance. Islet amyloid polypeptide (IAPP) aggregation is found to induce islet β-cell death in T2DM patients. Recently, we demonstrated that yakuchinone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4bd5f85ca88e39dc9217f1feaf8958
https://doi.org/10.1021/acs.jnatprod.0c01162
https://doi.org/10.1021/acs.jnatprod.0c01162
Autor:
Tzu Ying Sung, Liang Chieh Chen, Ssu Ting Lien, Yi Wen Wu, Sin Ting Ngo, Shiow Lin Pan, Shih Chung Yen, Hui Ju Tseng, Kai Cheng Hsu, Tony Eight Lin, Han Li Huang, Wei Jan Huang
Publikováno v:
Journal of Natural Products. 84:1-10
Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis and a high degree of relapse seen in patients. Overexpression of FMS-like tyrosine kinase 3 (FLT3) is associated with up to 70% of AML patients. Wild-type FLT3 induces prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cbdcba313ed0a9eb9130dd48de0e79
https://doi.org/10.1021/acs.jnatprod.0c00589
https://doi.org/10.1021/acs.jnatprod.0c00589
Autor:
Shih-Chung Yen, Liang-Chieh Chen, Han-Li Huang, Wei-Chun HuangFu, Yi-Ying Chen, Tony Eight Lin, Ssu-Ting Lien, Hui-Ju Tseng, Tzu-Ying Sung, Jui-Hua Hsieh, Wei-Jan Huang, Shiow-Lin Pan, Kai-Cheng Hsu
Publikováno v:
Bioorganic chemistry. 121
Fms-like tyrosine kinase 3 (FLT3) is considered a promising therapeutic target for acute myeloid leukemia (AML) in the clinical. However, monotherapy with FLT3 inhibitor is usually accompanied by drug resistance. Dual inhibitors might be therapeutica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55b8adc53696f642900e3553c7aed61
https://pubmed.ncbi.nlm.nih.gov/35182882
https://pubmed.ncbi.nlm.nih.gov/35182882
Publikováno v:
Molecules, Vol 22, Iss 11, p 1897 (2017)
Hispidulin is a naturally occurring flavone known to have various Central nervous system (CNS) activities. Proposed synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall yields. To so
Externí odkaz:
https://doaj.org/article/f33a7b9010804531b7222d475903bea9