Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Hui-Chen Lu"'
Autor:
Sen Yang, Zhen-Xian Niou, Andrea Enriquez, Jacob LaMar, Jui-Yen Huang, Karen Ling, Paymaan Jafar-Nejad, Jonathan Gilley, Michael P. Coleman, Jason M. Tennessen, Vidhya Rangaraju, Hui-Chen Lu
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-31 (2024)
Abstract Background Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide monon
Externí odkaz:
https://doaj.org/article/b4cc4bd0d6814ca5997b7215a718255b
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-32 (2023)
Abstract Human studies consistently identify bioenergetic maladaptations in brains upon aging and neurodegenerative disorders of aging (NDAs), such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and Amyotrophic lateral scler
Externí odkaz:
https://doaj.org/article/9d78ed4ead9a4253aabac4424d230b35
Autor:
David L. Haggerty, Gregory G. Grecco, Jui-Yen Huang, Emma H. Doud, Amber L. Mosley, Hui-Chen Lu, Brady K. Atwood
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
As problematic opioid use has reached epidemic levels over the past 2 decades, the annual prevalence of opioid use disorder (OUD) in pregnant women has also increased 333%. Yet, how opioids affect the developing brain of offspring from mothers experi
Externí odkaz:
https://doaj.org/article/a66d343100e74303b720478035edb367
Publikováno v:
BBA Advances, Vol 2, Iss , Pp 100054- (2022)
Maternal cannabis use during lactation may expose developing infants to cannabinoids (CBs) such as ∆-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBs modulate lipid signaling molecules in the central nervous system in age- and cell-dependent
Externí odkaz:
https://doaj.org/article/6c288daf76e14bd484f72a0a9da89e0d
Autor:
Gregory G Grecco, Briana E Mork, Jui-Yen Huang, Corinne E Metzger, David L Haggerty, Kaitlin C Reeves, Yong Gao, Hunter Hoffman, Simon N Katner, Andrea R Masters, Cameron W Morris, Erin A Newell, Eric A Engleman, Anthony J Baucum, Jiuen Kim, Bryan K Yamamoto, Matthew R Allen, Yu-Chien Wu, Hui-Chen Lu, Patrick L Sheets, Brady K Atwood
Publikováno v:
eLife, Vol 10 (2021)
Despite the rising prevalence of methadone treatment in pregnant women with opioid use disorder, the effects of methadone on neurobehavioral development remain unclear. We developed a translational mouse model of prenatal methadone exposure (PME) tha
Externí odkaz:
https://doaj.org/article/5a76cf5be8ef4e9aa4a2a863c7ea3745
Autor:
Tabassum Majid, Yousuf O. Ali, Deepa V. Venkitaramani, Ming-Kuei Jang, Hui-Chen Lu, Robia G. Pautler
Publikováno v:
NeuroImage: Clinical, Vol 4, Iss C, Pp 711-717 (2014)
Background: Axonal transport is vital for neurons and deficits in this process have been previously reported in a few mouse models of Alzheimer's disease prior to the appearance of plaques and tangles. However, it remains to be determined whether axo
Externí odkaz:
https://doaj.org/article/cdaf9916cbab47f7b9bcb2c8c94459c0
Autor:
Yousuf O Ali, Hunter M Allen, Lei Yu, David Li-Kroeger, Dena Bakhshizadehmahmoudi, Asante Hatcher, Cristin McCabe, Jishu Xu, Nicole Bjorklund, Giulio Taglialatela, David A Bennett, Philip L De Jager, Joshua M Shulman, Hugo J Bellen, Hui-Chen Lu
Publikováno v:
PLoS Biology, Vol 14, Iss 6, p e1002472 (2016)
Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive function and negatively with AD
Externí odkaz:
https://doaj.org/article/214c6e1d1d9e4c9b9cfeb78a98996191
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147620 (2016)
Nicotinamide mononucleotide adenylyl transferases (NMNATs) are essential neuronal maintenance factors postulated to preserve neuronal function and protect against axonal degeneration in various neurodegenerative disease states. We used in vitro and i
Externí odkaz:
https://doaj.org/article/4ece86973bbd4dea92ea6573e3a677ec
Autor:
Chia-Shan Wu, Hongmei Chen, Hao Sun, Jie Zhu, Chris P Jew, James Wager-Miller, Alex Straiker, Corinne Spencer, Heather Bradshaw, Ken Mackie, Hui-Chen Lu
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60314 (2013)
The G-protein coupled receptor 55 (GPR55) is activated by lysophosphatidylinositols and some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic/inflammatory pain, cancer and bone physiology. However, little is known about the
Externí odkaz:
https://doaj.org/article/2388941bea0a47f49e5ec54258018413
Autor:
Chris P Jew, Chia-Shan Wu, Hao Sun, Jie Zhu, Jui-Yen Huang, Dinghui Yu, Nicholas J Justice, Hui-Chen Lu
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70415 (2013)
The group I metabotropic glutamate receptor 5 (mGluR5) has been implicated in the pathology of various neurological disorders including schizophrenia, ADHD, and autism. mGluR5-dependent synaptic plasticity has been described at a variety of neural co
Externí odkaz:
https://doaj.org/article/4d41dd6556c54d80af320b08d5f0d6a2