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Autor: Hui-Bao Gao, Pengyu Zhang, Rong Yang, Qiang Lin

Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 47, Iss 2, Pp 101-109 (2014)
Brazilian Journal of Medical and Biological Research, Volume: 47, Issue: 2, Pages: 101-109, Published: FEB 2014
Brazilian Journal of Medical and Biological Research v.47 n.2 2014
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC

In the current literature, there is evidence that psychological factors can affect the incidence and progression of some cancers. Interleukin 6 (IL-6) is known to be elevated in individuals experiencing chronic stress and is also involved in oncogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2698999c4a14a55c176fa3bdaf634a2
https://doi.org/10.1590/1414-431x20133346

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Chronic stress induces ageing-associated degeneration in rat Leydig cells

Autor: Yong Chen, Qian Wang, Ping Zhang, Qiang Lin, Fei-Fei Wang, Hui-Bao Gao

Publikováno v: Asian Journal of Andrology. 14:643-648

Several studies have suggested that stress and ageing exert inhibitory effects on rat Leydig cells. In a pattern similar to the normal process of Leydig cell ageing, stress-mediated increases in glucocorticoid levels inhibit steroidogenic enzyme expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd095fb6391013de4e865c10ced7fde6
https://doi.org/10.1038/aja.2011.183

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NFAT2 is implicated in corticosterone-induced rat Leydig cell apoptosis

Autor: Hui-Bao Gao, Wei-Ran Chai, Qian Wang

Publikováno v: Asian Journal of Andrology. 9:623-633

Aim: To investigate the activation of the nuclear factor of activated T cells (NFAT) and its function in the corticosterone (CORT)-induced apoptosis of rat Leydig cells. Methods: NFAT in rat Leydig cells was detected by Western blotting and immunohis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130f57cfb061243da9502d92b00f3cc8
https://doi.org/10.1111/j.1745-7262.2007.00257.x

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Involvement of nuclear factor-kappa B on corticosterone-induced rat Leydig cell apoptosis

Autor: Qian Wang, Hui-Bao Gao

Publikováno v: Asian Journal of Andrology. 8:693-702

Aim: To investigate the activation of nuclear factor-kappa B (NF-kappa B) and its function in glucocorticoid-induced Leydig cell apoptosis. Methods: The Leydig cells were isolated from male Sprague-Dawley rats (90 days of age) and were incubated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041cfa1b90a874989489f66d42e4f4ba
https://doi.org/10.1111/j.1745-7262.2006.00212.x

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Mechanisms of glucocorticoid-induced Leydig cell apoptosis

Autor: Hui-Bao Gao, Matthew P. Hardy, Qiang-Su Guo, Hai-Yan You, Ming-Han Tong, Ren-Shan Ge, Yan-Qin Hu

Publikováno v: Molecular and Cellular Endocrinology. 199:153-163

The high levels of corticosterone (CORT) that are typically achieved during stress induce apoptotic death of Leydig cells. The intracellular mechanisms by which CORT acts on Leydig cells to induce apoptosis are unknown, and the present study tested f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090e910df45e0ae137dce98d9a025948
https://doi.org/10.1016/s0303-7207(02)00290-3

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Identification of a Kinetically Distinct Activity of 11β-Hydroxysteroid Dehydrogenase in Rat Leydig Cells1

Autor: Vijaya L. Nacharaju, Hui-Bao Gao, Glen L. Gunsalus, Ren-Shan Ge, Matthew P. Hardy

Publikováno v: Endocrinology. 138:2435-2442

Leydig cells are susceptible to direct glucocorticoid-mediated inhibition of testosterone biosynthesis but can counteract the inhibition through 11β-hydroxysteroid dehydrogenase (11β-HSD), which oxidatively inactivates glucocorticoids. Of the two i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::801e44bcb1cde6b3f0d9aa7cd565b0fc
https://doi.org/10.1210/endo.138.6.5165

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Hormonal Regulation of Oxidative and Reductive Activities of 11β-Hydroxysteroid Dehydrogenase in Rat Leydig Cells1

Autor: Hui-Bao Gao, Vijaya Lakshmi, Ren-Shan Ge, Alexandru Marandici, Matthew P. Hardy

Publikováno v: Endocrinology. 138:156-161

We have proposed that the 11β-hydroxysteroid dehydrogenase (11β-HSD) of Leydig cells protects against glucocorticoid-induced inhibition of testosterone (T) production. However, Leydig cells express type I 11β-HSD, which has been shown to be reduct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17bce641ea83a52e8a249114f2bb7019
https://doi.org/10.1210/endo.138.1.4837

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Suppression of endogenous corticosterone levels in vivo increases the steroidogenic capacity of purified rat Leydig cells in vitro

Autor: Carl Monder, Li-Xin Shan, Hui-Bao Gao, Matthew P. Hardy

Publikováno v: Endocrinology. 137:1714-1718

In vitro studies have shown that corticosterone (B) directly inhibits testosterone (T) production by purified Leydig cells but does so only at high concentrations. 11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) in Leydig cells oxidatively inactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62ca2e2f40e24a1d1f53d3b8c55e0b1
https://doi.org/10.1210/endo.137.5.8612506

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Stress induces glucocorticoid-mediated apoptosis of rat Leydig cells in vivo

Autor: Ping Zhang, Hui-Bao Gao, Yong Chen, Fei-Fei Wang, Qian Wang

Publikováno v: Stress (Amsterdam, Netherlands). 15(1)

Stress can disrupt endocrine signalling in the male reproductive axis through high concentrations of glucocorticoids, the hallmark of stress. Our previous work revealed that a stress level of exogenous glucocorticoids could induce apoptosis of rat Le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bac6775e39d68ad1fd3f7a5c404ca7
https://pubmed.ncbi.nlm.nih.gov/21790368

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Luteinizing hormone induces expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells

Autor: Qian Wang, Ping Zhang, Hui-Bao Gao

Publikováno v: Reproductive Biology and Endocrinology : RB&E
Reproductive Biology and Endocrinology, Vol 7, Iss 1, p 39 (2009)

Background Leydig cells are the primary source of testosterone in male vertebrates. The biosynthesis of testosterone in Leydig cells is strictly dependent on luteinizing hormone (LH). On the other hand, it can be directly inhibited by excessive gluco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ae717cedabb7b4c8ac9f2e2c59c41b
https://doi.org/10.1186/1477-7827-7-39

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