Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hui Zhong Zhou"'
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 291:H714-H723
Poly(ADP-ribose) polymerase-1 (PARP-1), the most abundant member of the PARP family, is a nuclear enzyme that catalyzes ADP-ribose transfer from NAD+to specific acceptor proteins in response to DNA damage. Excessive PARP-1 activation is an important
Publikováno v:
Cardiovascular Drugs and Therapy. 18:421-431
As pyrroloquinoline quinone (PQQ) is a redox cofactor in mammals, we asked if it is cardioprotective. Rats were subjected to 2 h of left anterior descending (LAD) coronary artery ligation without reperfusion (model 1, ischemia). In model 2 (ischemia/
Autor:
Daria Mochly-Rosen, Mary O. Gray, Hui Zhong Zhou, Robert O. Messing, Peili Zhu, Ingeborg Schafhalter-Zoppoth
Publikováno v:
Journal of Biological Chemistry. 279:3596-3604
Signaling pathways involving protein kinase C isozymes are modulators of cardiovascular development and response to injury. Protein kinase C epsilon activation in cardiac myocytes reduces necrosis caused by coronary artery disease. However, it is unc
Autor:
Yelizaveta Sher, Elena Maklashina, Gary Cecchini, Hui-Zhong Zhou, Mary O. Gray, Joel S. Karliner
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1556(1):6-12
The multi-subunit mammalian NADH–ubiquinone oxidoreductase (complex I) is part of the mitochondrial electron transport chain and physiologically serves to reduce ubiquinone with NADH as the electron donor. The three-dimensional structure of this en
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 283:H165-H174
C57BL/6 mice were fed 18% ethanol (vol/vol) in drinking water for 12 wk. Isovolumic hearts were subjected to 20 min of ischemia and 30 min of reperfusion on a Langendorff apparatus. There were no differences in baseline hemodynamic function between h
Autor:
Zhu-Qiu Jin, Peili Zhu, Hui Zhong Zhou, Daria Mochly-Rosen, Edward J. Goetzl, Mary O. Gray, Norman Honbo, Robert O. Messing, Joel S. Karliner
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 282:H1970-H1977
Sphingosine-1-phosphate (S1P) protects neonatal rat cardiac myocytes from hypoxic damage through unknown signaling pathways. We tested the hypothesis that S1P-induced cardioprotection requires activation by the epsilon-isoform of protein kinase C (PK
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 277:H2091-H2097
Sustained protection against ischemia-reperfusion injury is not available for patients at risk for myocardial infarction who may require emergent reperfusion therapy. Whereas ischemic preconditioning and adenosinergic agents reduce myocardial injury,
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 275:H50-H56
We recently discovered that regular alcohol consumption reduces ischemia-reperfusion injury to the same degree as ischemic preconditioning in guinea pig hearts. Ischemic preconditioning, like this cardioprotective effect of alcohol, is mediated by ad
Autor:
Masami, Miyamae, Naochika, Domae, Hui-Zhong, Zhou, Shingo, Sugioka, Ivan, Diamond, Vincent M, Figueredo
Publikováno v:
Experimental and clinical cardiology. 8(4)
Regular alcohol consumption decreases the incidence of myocardial infarction (MI) and improves post-MI survival. It has previously been reported that chronic ethanol exposure induces long-term protection against cardiac ischemia/reperfusion injury, w
Publikováno v:
Circulation. 116
Background: Moderate alcohol consumption is cardioprotective in large part through mechanisms that converge on mitochondria. As a primary entry point for reducing equivalents into the respiratory chain, the state of complex I activation has important