Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Hui Sun, Lee"'
Autor:
Neel I Nissen, Kristin R Anderson, Huaixing Wang, Hui Sun Lee, Carly Garrison, Samantha A Eichelberger, Kasarah Ackerman, Wonpil Im, Julie M Miwa
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199643 (2018)
Neuronal nicotinic acetylcholine receptors (nAChRs) of the cholinergic system have been linked to antinociception, and therefore could be an alternative target for pain alleviation. nAChR activity has been shown to be regulated by the nicotinic modul
Externí odkaz:
https://doaj.org/article/4b3fe94746154c2baf995650decb47f4
Publikováno v:
BioTechniques, Vol 46, Iss 7, Pp 534-542 (2009)
In this report we describe transposon-directed base-exchange mutagenesis (TDEM), an efficient and controllable method for introducing a mutation into a gene. Each round of TDEM can remove up to 11 base pairs from a randomly selected site within the t
Externí odkaz:
https://doaj.org/article/16bf077639ad41ba9c3a7158aca37f79
Publikováno v:
Journal of Chemical Theory and Computation. 15:6524-6535
Accurate modeling of ligand-binding site structures plays a critical role in structure-based virtual screening. However, the structures of ligand-binding site in most predicted protein models are generally of low quality and in need of refinements. I
Autor:
InSuk Joung, Nathan R. Kern, Jooyoung Lee, Hui Sun Lee, Sunhwan Jo, Sang-Jun Park, Jumin Lee, Wonpil Im, Yifei Qi, Keehyung Joo
Publikováno v:
Glycobiology. 29:320-331
Characterizing glycans and glycoconjugates in the context of three-dimensional structures is important in understanding their biological roles and developing efficient therapeutic agents. Computational modeling and molecular simulation have become an
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 3, p e1002946 (2013)
Understanding glycan structure and dynamics is central to understanding protein-carbohydrate recognition and its role in protein-protein interactions. Given the difficulties in obtaining the glycan's crystal structure in glycoconjugates due to its fl
Externí odkaz:
https://doaj.org/article/2859271def8f40cfbd31a0de9be218b2
Autor:
Venkatachalam Rajakannan, Hui-Sun Lee, Seon-Ha Chong, Han-Bong Ryu, Ji-Young Bae, Eun-Young Whang, Jae-Wan Huh, Sung-Woo Cho, Lin-Woo Kang, Han Choe, Robert C Robinson
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25226 (2011)
BACKGROUND: UDP-glucose dehydrogenase (UGDH) is the sole enzyme that catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The product is used in xenobiotic glucuronidation in hepatocytes and in the production of proteoglycans that are invo
Externí odkaz:
https://doaj.org/article/3e51143fdf9144859cbfc7c71c7ba6ae
Autor:
Leah Pedoeim, Juan Wang, Yoshiyuki Murata, Wonpil Im, Shintaro Munemasa, June M. Kwak, Chuanli Ju, Barbara Rodriguez, Heng-Cheng Hu, Dongdong Kong, Eiji Okuma, Yuree Lee, Hui Sun Lee, Zhen-Ming Pei, Daeshik Cho
Publikováno v:
CELL REPORTS(17): 10
Plant glutamate receptor homologs (GLRs) have long been proposed to function as ligand-gated Ca2+ channels, but no in planta evidence has been provided. Here, we present genetic evidence that Arabidopsis GLR3.1 and GLR3.5 form Ca2+ channels activated
Autor:
Wonpil Im, Soohyung Park, Huan Rui, Sang-Jun Park, Hui Sun Lee, Alexander D. MacKerell, Seonghoon Kim, Jeffrey B. Klauda, Dhilon S. Patel, Xi Cheng, Kyu Il Lee, Jumin Lee, Benoît Roux, Sunhwan Jo, Andrew H. Beaven, Yifei Qi
Publikováno v:
Journal of Computational Chemistry. 38:1114-1124
CHARMM-GUI, http://www.charmm-gui.org, is a web-based graphical user interface that prepares complex biomolecular systems for molecular simulations. CHARMM-GUI creates input files for a number of programs including CHARMM, NAMD, GROMACS, AMBER, GENES
Publikováno v:
The journal of physical chemistry. B. 122(47)
Lipases are useful as catalysts, particularly for the kinetic resolution of racemic alcohols and esters. However, their industrial applications are limited by their poor activities in organic media. We recently found that a lipoprotein lipase from Bu
Publikováno v:
ACS Combinatorial Science. 18:36-42
Many biologically active α-helical peptides adopt amphiphilic helical structures that contain hydrophobic residues on one side and hydrophilic residues on the other side. Therefore, α-helix mimetics capable of mimicking such amphiphilic helical pep