Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hui Pen Tan"'
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
Nucleic acid aptamers as antibody alternatives bind specifically to target molecules. These aptamers are generated by isolating candidates from libraries with random sequence fragments, through an evolutionary engineering system. We recently reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c06d5c71cc19267fd201231313ad7d
https://doi.org/10.1098/rstb.2022.0031
https://doi.org/10.1098/rstb.2022.0031
Autor:
Vanessa Weixun Lim, Ken-ichiro Matsunaga, William Sun, Shawn Vasoo, Ichiro Hirao, Yee Sin Leo, Yu Qian Wong, Hui Pen Tan, Michiko Kimoto
Publikováno v:
Nucleic Acids Research
Genetic alphabet expansion of DNA by introducing unnatural bases (UBs), as a fifth letter, dramatically augments the affinities of DNA aptamers that bind to target proteins. To determine whether UB-containing DNA (UB-DNA) aptamers obtained by affinit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89bfae5f66a522d2bfa873a78cf34b84
http://europepmc.org/articles/PMC8599795
http://europepmc.org/articles/PMC8599795
Publikováno v:
Biopolymers
We present cognate base pair selectivity in template‐dependent ligation by T4 DNA ligase using a hydrophobic unnatural base pair (UBP), Ds‐Pa. T4 DNA ligase efficiently recognizes the Ds‐Pa pairing at the conjugation position, and Ds excludes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359b427a3c71ed79e63ecdc686b3cd96
https://pubmed.ncbi.nlm.nih.gov/33156531
https://pubmed.ncbi.nlm.nih.gov/33156531
Autor:
Wai Ling Chan, Bo Zhang, Thomas H. Keller, Wouter Schul, Min Qing, Pei Yong Shi, Andy Yip, Kristen A. Bernard, Gang Zou, Hao Ying Xu, Suresh B. Lakshminarayana, Gang Wang, Anne Goh, Wei Liu, Min Dong, Boping Liu, Hui Pen Tan, Handan He, Qing Yin Wang, Margaret Weaver, Feng Gu, Yen Liang Chen, Zheng Yin, Pornwaratt Niyomrattanakit, Chuan Young Ng, Arkadius Pichota, Christine E. Garrett, Véronique Dartois, Joanne Y.H. Lim, Ravinder Reddy Kondreddi, Jeyaraj Duraiswamy, Kai Lin, Chin Chin Lim, Karen Beltz
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20435-20439
Dengue virus (DENV), a mosquito-borne flavivirus, is a major public health threat. The virus poses risk to 2.5 billion people worldwide and causes 50 to 100 million human infections each year. Neither a vaccine nor an antiviral therapy is currently a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a316c5d40ed9639ddcd32990e5f5a43e
https://doi.org/10.1073/pnas.0907010106
https://doi.org/10.1073/pnas.0907010106
Autor:
Min Qing, Wai Ling Chan, Boping Liu, Melissa Lo, Helen Gu, Hui Pen Tan, Wouter Schul, Handan He, Ranga Rao, Hao Ying Xu, Gang Wang, Jeyaraj Duraiswamy, Thomas H. Keller, Sarah Liung, Pei Yong Shi, Yen Liang Chen, Chin Chin Lim, Ravinder Reddy Kondreddi, Andy Yip, Zheng Yin
Publikováno v:
Antimicrobial agents and chemotherapy. 54(7)
We recently reported that (2 R ,3 R ,4 R ,5 R )-2-(4-amino-pyrrolo[2,3- d ]pyrimidin-7-yl)-3-ethynyl-5-hydroxy-methyl-tetrahydro-furan-3,4-diol is a potent inhibitor of dengue virus (DENV), with 50% effective concentration (EC 50 ) and cytotoxic conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91beaee7c743c979448a64d12f871a38
https://pubmed.ncbi.nlm.nih.gov/20457821
https://pubmed.ncbi.nlm.nih.gov/20457821