Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Hui K, Gan"'
Autor:
Nalin H. Maniya, Sonu Kumar, Jeffrey L. Franklin, James N. Higginbotham, Andrew M. Scott, Hui K. Gan, Robert J. Coffey, Satyajyoti Senapati, Hsueh-Chia Chang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract We present a quantitative sandwich immunoassay for CD63 Extracellular Vesicles (EVs) and a constituent surface cargo, EGFR and its activity state, that provides a sensitive, selective, fluorophore-free and rapid alternative to current EV-bas
Externí odkaz:
https://doaj.org/article/73f922b965a546b2a477dcf2d44e21d8
Autor:
Eng-Siew Koh, Mustafa Khasraw, Elizabeth H Barnes, Kyle M Walsh, Mark Rosenthal, Rodney J Hicks, Farshad Foroudi, Hui K Gan, Anna K Nowak, Dale L Bailey, Paul Roach, Arian Lasocki, Robyn Leonard, Roel Verhaak, Andrew M Scott, Alisha Moore, Bradford A Moffat, Clare Senko, Roslyn J Francis, Martin Ebert, Sze Ting Lee, Eddie Lau, Greg Fitt, Robert Coffey, Richard De Abreu Lourenco, Lucas Adda, Paul A Thomas, Michael Back
Publikováno v:
BMJ Open, Vol 13, Iss 8 (2023)
Introduction Glioblastoma is the most common aggressive primary central nervous system cancer in adults characterised by uniformly poor survival. Despite maximal safe resection and postoperative radiotherapy with concurrent and adjuvant temozolomide-
Externí odkaz:
https://doaj.org/article/d8d21057c5584e9388379c1d9d0c188d
Autor:
Georgia K. B. Halkett, Lauren J. Breen, Melissa Berg, Rebecca Sampson, Hao-Wen Sim, Hui K. Gan, Benjamin Y. Kong, Anna K. Nowak, Bryan W. Day, Rosemary Harrup, Melissa James, Frank Saran, Brett Mcfarlane, Chris Tse, Eng-Siew Koh
Publikováno v:
Current Oncology, Vol 29, Iss 12, Pp 9928-9955 (2022)
The aim of this project was to determine research priorities, barriers, and enablers for adult primary brain tumour research in Australia and New Zealand. Consumers, health professionals, and researchers were invited to participate in a two-phase mod
Externí odkaz:
https://doaj.org/article/6cd87a96459d43ed8dda66d8c3a38599
Autor:
Lucy Gately, Katharine Drummond, Mark Rosenthal, Rosemary Harrup, Anthony Dowling, Andrew Gogos, Zarnie Lwin, Ian Collins, David Campbell, Elizabeth Ahern, Claire Phillips, Hui K. Gan, Iwan Bennett, Oliver M. Sieber, Peter Gibbs
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Real-world data (RWD) is increasingly being embraced as an invaluable source of information to address clinical and policy-relevant questions that are unlikely to ever be answered by clinical trials. However, the largely unrealise
Externí odkaz:
https://doaj.org/article/dde2958b8619435fbac30562014e21eb
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 2, Pp 252-277 (2022)
The recent approvals for antibody-drug conjugates (ADCs) in multiple malignancies in recent years have fuelled the ongoing development of this class of drugs. These novel agents combine the benefits of high specific targeting of oncogenic cell surfac
Externí odkaz:
https://doaj.org/article/3d8ef975652545ae9c093e8ae0cb2d09
Autor:
Zarnie Lwin, Eng-Siew Koh, Elizabeth H Barnes, Rosemary Harrup, Hui K Gan, Anna K Nowak, Craig Gedye, Sonia Yip, Benjamin Y Kong, Hao-Wen Sim, Jonathon Parkinson, Rosalind Jeffree, Elizabeth J Hovey, Merryn Hall, Emily Tu, Mark B Pinkham, Candace Carter, Anthony Dowling, John S Simes
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Introduction Glioblastoma (GBM) is the most common malignant primary central nervous system cancer in adults. The objective of the Multi-Arm GlioblastoMa Australasia (MAGMA) trial is to test hypotheses in real world setting to improve survival of peo
Externí odkaz:
https://doaj.org/article/e3e6c47aec9f4f8cacc7e973ad7a136f
Autor:
Maximilian J. Mair, Rupert Bartsch, Emilie Le Rhun, Anna S. Berghoff, Priscilla K. Brastianos, Javier Cortes, Hui K. Gan, Nancy U. Lin, Andrew B. Lassman, Patrick Y. Wen, Michael Weller, Martin van den Bent, Matthias Preusser
Publikováno v:
Nature Reviews Clinical Oncology. 20:372-389
Antibody–drug conjugates (ADCs), a class of targeted cancer therapeutics combining monoclonal antibodies with a cytotoxic payload via a chemical linker, have already been approved for the treatment of several cancer types, with extensive clinical d
Autor:
Catherine G. Fitzgerald Dickmann, Alexander F. McDonald, Nhi Huynh, Angela Rigopoulos, Zhanqi Liu, Nancy Guo, Laura D. Osellame, Michael A. Gorman, Michael W. Parker, Hui K. Gan, Andrew M. Scott, Uwe Ackermann, Ingrid J. G. Burvenich, Jonathan M. White
Publikováno v:
Chemical Communications. 59:3126-3129
A fluorine-18 labelled probe was developed to target bromodomain and extraterminal (BET) proteins for molecular imaging of cancer with positron emission tomography.
Publikováno v:
Cancers, Vol 14, Iss 6, p 1454 (2022)
Radioimmunoconjugates consist of a monoclonal antibody (mAb) linked to a radionuclide. Radioimmunoconjugates as theranostics tools have been in development with success, particularly in hematological malignancies, leading to approval by the US Food a
Externí odkaz:
https://doaj.org/article/e678ac54095140e799c2f15f0a073adf
Autor:
Andrew B Lassman, Stephanie L Pugh, Tony J C Wang, Kenneth Aldape, Hui K Gan, Matthias Preusser, Michael A Vogelbaum, Erik P Sulman, Minhee Won, Peixin Zhang, Golnaz Moazami, Marian S Macsai, Mark R Gilbert, Earle E Bain, Vincent Blot, Peter J Ansell, Suvajit Samanta, Madan G Kundu, Terri S Armstrong, Jeffrey S Wefel, Clemens Seidel, Filip Y de Vos, Sigmund Hsu, Andrés F Cardona, Giuseppe Lombardi, Dmitry Bentsion, Richard A Peterson, Craig Gedye, Véronique Bourg, Antje Wick, Walter J Curran, Minesh P Mehta
Publikováno v:
Neuro-Oncology. 25:339-350
Background Approximately 50% of newly diagnosed glioblastomas (GBMs) harbor epidermal growth factor receptor gene amplification (EGFR-amp). Preclinical and early-phase clinical data suggested efficacy of depatuxizumab mafodotin (depatux-m), an antibo