Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hui C. Kimko"'
Autor:
Ralph E. Kauffman, Jeffrey L. Blumer, Joseph Massarella, Susan M. Abdel-Rahman, Samuel Maldonado, Hui C. Kimko, Christopher Curtin, Kevin Shalayda, John S. Bradley, Richard F. Jacobs, Gregory L. Kearns
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:2668-2673
This investigation was designed to evaluate the single-dose pharmacokinetics of itraconazole, hydroxyitraconazole, and hydroxypropyl-β-cyclodextrin (HP-β-CD) after intravenous administration to children at risk for fungal infection. Thirty-three ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df3a38136ce4e667d59acb12bd1c832
https://doi.org/10.1128/aac.00297-07
https://doi.org/10.1128/aac.00297-07
Autor:
Rienk Pypstra, Thomas P. Lodise, Karen Bush, James B. Kahn, Gary J. Noel, George L. Drusano, Bindu Murthy, Hui C. Kimko
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:2378-2387
Ceftobiprole is a broad-spectrum cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA) that is undergoing phase III trials for the treatment of complicated skin and skin structure infections and nosocomial pneumonia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d3761687a487306aae1641e0900bd4
https://doi.org/10.1128/aac.01181-06
https://doi.org/10.1128/aac.01181-06
Autor:
William J. Jusko, Wojciech Krzyzanski, Juan J. Perez-Ruixo, Andrew T. Chow, Hui C. Kimko, Vladimir Piotrovsky
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 32:767-793
Pharmacokinetic/pharmacodynamic (PK/PD) models for hematological drug effects exist that assume that cells are produced by a zero- or first-order process, survive for a specific duration (cell lifespan), and then are lost. Due to the fact that delay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86961ff196ea4115db1f82b1f92b8b94
https://doi.org/10.1007/s10928-005-0019-1
https://doi.org/10.1007/s10928-005-0019-1
Publikováno v:
Clinical Pharmacology & Therapeutics. 68:568-577
A completed phase 3 trial result was simulated 100 times on the basis of a simulation model of quetiapine fumarate (Seroquel), an antischizophrenic agent. The simulation was executed by analysts who were completely blinded from results of the actual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2ae5705ff2a575ee560297d44e1ab5
https://doi.org/10.1067/mcp.2000.110975
https://doi.org/10.1067/mcp.2000.110975
Publikováno v:
Clinical Pharmacokinetics. 37:457-470
Methylphenidate is prescribed for over 90% of children in the US diagnosed as having attention-deficit hyperactivity disorder (ADHD). Although ADHD has been widely studied, the use of methylphenidate in ADHD still poses a number of unresolved questio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa52d35ed3586dc493f5b176cf7ca89
https://doi.org/10.2165/00003088-199937060-00002
https://doi.org/10.2165/00003088-199937060-00002
Autor:
Mahesh N. Samtani, Juan Jose Perez-Ruixo, Eugene Cox, Filip De Ridder, Hui C. Kimko, Surya Mohanty, An Vermeulen
Publikováno v:
Biosimulation in Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51f616d95f6010f27e96797e9754adc7
https://doi.org/10.1002/9783527622672.ch1
https://doi.org/10.1002/9783527622672.ch1
Publikováno v:
Current medical research and opinion. 21(4)
To demonstrate using pharmacokinetic (PK) modeling and simulation, that the PK that the PK parameters for drug exposure with galantamine parameters for drug exposure with galantamine immediate-release (IR) tablet and galantamine extended-release (ER)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcc7f382873446c699189ff2f65f6ca
https://pubmed.ncbi.nlm.nih.gov/15899095
https://pubmed.ncbi.nlm.nih.gov/15899095
Autor:
Jur Strobos, Michael A Jones, Rhoda B. Schleicher, Murray P. Ducharme, Paul A. Seligman, Naomi V. Dahl, Hui C Kimko
Publikováno v:
Pharmacotherapy. 24(5)
Study Objectives. To determine the single-dose pharmacokinetics of intravenous sodium ferric gluconate complex in sucrose injection (SFGC) in iron-deficient human volunteers, and to assess iron transport. Design. Open-label, randomized study. Setting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9a06a5d9b368a8c1cfb90b080e7f30
https://pubmed.ncbi.nlm.nih.gov/15162891
https://pubmed.ncbi.nlm.nih.gov/15162891
Publikováno v:
Clinical pharmacology and therapeutics. 73(4)
Objective Our objective was to develop a population pharmacokinetic and pharmacodynamic model of etanercept in patients with rheumatoid arthritis, with the American College of Rheumatology response criterion of 20% improvement (ACR20) used as a binar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb138e6b2e99c16f5be162b56c3e8d94
https://pubmed.ncbi.nlm.nih.gov/12709725
https://pubmed.ncbi.nlm.nih.gov/12709725
Autor:
Hui C. Kimko, Stephen B. Duffull
Publikováno v:
Simulation for Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective
Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19f3f10aa4821759c30c7febbb87025f
https://doi.org/10.1201/9780203910276
https://doi.org/10.1201/9780203910276