Zobrazeno 1 - 10
of 468
pro vyhledávání: '"Hui‐Lin Pan"'
Autor:
Ashok Subedi, Asieh Etemad, Aadhya Tiwari, Yuying Huang, Biji Chatterjee, Samantha M. McLeod, Yungang Lu, DiAngelo Gonzalez, Krishna Ghosh, Mario Sirito, Sanjay K. Singh, Elisa Ruiz, Sandra L. Grimm, Cristian Coarfa, Hui-Lin Pan, Sadhan Majumder
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The transcription repressor REST in the dorsal root ganglion (DRG) is upregulated by peripheral nerve injury and promotes the development of chronic pain. However, the genes targeted by REST in neuropathic pain development remain unclear. Th
Externí odkaz:
https://doaj.org/article/96c8383e4d684ecbb3fc611ee169bb66
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
N-methyl-D-aspartate receptors (NMDARs) play a critical role in excitotoxicity caused by ischemic stroke, but NMDAR antagonists have failed to be translated into clinical practice for treating stroke patients. Recent studies suggest that targeting th
Externí odkaz:
https://doaj.org/article/dc0480e23d69478280cb00f0251682d4
Autor:
Wen-Qiang Ge, Ou-Yang Zhan-Mu, Chao Chen, Hong Zhang, Xiao-Yu Wang, Xin Liu, Li Li, Yu-Ye Lan, Chen-Nan Li, Jia-Can Sun, Run-Lin Shi, Zi-Yue Dou, Hui-Lin Pan, Hong-Ping Li, Xiang-Hong Jing, Man Li
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Chronic itch severely reduces the quality of life of patients. Electroacupuncture (EA) is widely used to treat chronic itch. However, the underlying mechanism of this therapeutic action of EA is largely unknown. Cannabinoid CB1 receptors in the ventr
Externí odkaz:
https://doaj.org/article/8fc84d33a7ce4ab6bf4141e39ef57f37
Autor:
Xue-Fei Hu, Hong Zhang, Ling-Ling Yu, Wen-Qiang Ge, Ou-Yang Zhan-mu, Yan-Zhen Li, Chao Chen, Teng-Fei Hou, Hong-Chun Xiang, Yuan-Heng Li, Yang-Shuai Su, Xiang-Hong Jing, Jie Cao, Hui-Lin Pan, Wei He, Man Li
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The therapeutic effects of electroacupuncture (EA) on the comorbidity of visceral pain and anxiety in patients with inflammatory bowel disease (IBD) is well known. It has been known that the ventral hippocampus (vHPC) and the cannabinoid type 1 recep
Externí odkaz:
https://doaj.org/article/de02f998a6f948879d9f6f030e71b1b1
Autor:
Hong Zhang, Wei He, Xue-Fei Hu, Yan-Zhen Li, Yong-Min Liu, Wen-Qiang Ge, Ou-Yang Zhanmu, Chao Chen, Yu-Ye Lan, Yang-Shuai Su, Xiang-Hong Jing, Bing Zhu, Hui-Lin Pan, Ling-Ling Yu, Man Li
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Inflammatory bowel disease (IBD) results in chronic abdominal pain in patients due to the presence of inflammatory responses in the colon. Electroacupuncture (EA) is effective in alleviating visceral pain and colonic inflammation associated with IBD.
Externí odkaz:
https://doaj.org/article/873c32d2de294336a1eef9a594833cc0
Autor:
Yongmin Liu, Min Jia, Caihua Wu, Hong Zhang, Chao Chen, Wenqiang Ge, Kexing Wan, Yuye Lan, Shiya Liu, Yuanheng Li, Mengyue Fang, Jiexi He, Hui-Lin Pan, Jun-Qiang Si, Man Li
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Type 1 and type 2 cannabinoid receptors (CB1 and CB2, respectively) mediate cannabinoid-induced analgesia. Loss of endogenous CB1 is associated with hyperalgesia. However, the downstream targets affected by ablation of CB1 in primary sensory neurons
Externí odkaz:
https://doaj.org/article/c56921ca953c441384905bcbc6d68b20
Autor:
Jinjun Chen, Lingyong Li, Shao-Rui Chen, Hong Chen, Jing-Dun Xie, Rita E. Sirrieh, David M. MacLean, Yuhao Zhang, Meng-Hua Zhou, Vasanthi Jayaraman, Hui-Lin Pan
Publikováno v:
Cell Reports, Vol 38, Iss 4, Pp 110308- (2022)
Externí odkaz:
https://doaj.org/article/6f495f000171454ebd6396114d09ed80
Autor:
Hong-Chun Xiang, Li-Xue Lin, Xue-Fei Hu, He Zhu, Hong-Ping Li, Ru-Yue Zhang, Liang Hu, Wen-Tao Liu, Yi-Lin Zhao, Yang Shu, Hui-Lin Pan, Man Li
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Chronic pain is a major clinical problem with limited treatment options. Previous studies have demonstrated that activation of adenosine monophosphate-activated protein kinase (AMPK) can attenuate neuropathic pain. Inflammation/im
Externí odkaz:
https://doaj.org/article/cf2567fb1a2a4580818ab3d004cdf59d
Autor:
Jinjun Chen, Lingyong Li, Shao-Rui Chen, Hong Chen, Jing-Dun Xie, Rita E. Sirrieh, David M. MacLean, Yuhao Zhang, Meng-Hua Zhou, Vasanthi Jayaraman, Hui-Lin Pan
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2307-2321 (2018)
Summary: α2δ-1, commonly known as a voltage-activated Ca2+ channel subunit, is a binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is unclear how α2δ-1 contributes to neuropathic pain and gabapentinoid action
Externí odkaz:
https://doaj.org/article/2cf04f4015de488dbe3b43686edf9e3c
Autor:
Lingyong Li, Shao-Rui Chen, Hong Chen, Lei Wen, Walter N. Hittelman, Jing-Dun Xie, Hui-Lin Pan
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1376-1383 (2016)
Summary: Chronic neuropathic pain is a debilitating condition that remains difficult to treat. Diminished synaptic inhibition by GABA and glycine and increased NMDA receptor (NMDAR) activity in the spinal dorsal horn are key mechanisms underlying neu
Externí odkaz:
https://doaj.org/article/230a00762cf04ab290b1fdf4ad046fd7