Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Huguette Savoie"'
Publikováno v:
Molecules, Vol 25, Iss 2, p 244 (2020)
Metallation of biomacromolecular species forms the basis for the anticancer activity of many metallodrugs. A major limitation of these compounds is that their reactivity is indiscriminate and can, in principle, occur in healthy tissue as well as canc
Externí odkaz:
https://doaj.org/article/0832581b2899437281487000a970769d
Publikováno v:
ChemBioChem. 22:2624-2631
In this study, we present a convenient method for the labelling of tyrosine residues on bovine serum albumin (BSA) and human serum albumin (HSA) and report for the first time their subsequent bio-orthogonal conjugation with porphyrins via "click" che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e174a45efc1c41802f9942e680a66caa
https://doi.org/10.1002/cbic.202100176
https://doi.org/10.1002/cbic.202100176
Publikováno v:
Inorganic Chemistry. 59:7884-7893
In this study, we report the synthesis and biological evaluation of a novel cationic porphyrin-[Ru(η6-arene)(C2O4)PTA] (RAPTA) conjugate with potential as a multimodal dual-therapeutic agent. In the absence of high intensity light, relative to untre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e496e5abb073d858b176ca63fcf4289a
https://doi.org/10.1021/acs.inorgchem.0c01044
https://doi.org/10.1021/acs.inorgchem.0c01044
Autor:
Steven Y. Yap, Huguette Savoie, Stephen J. Archibald, Ross W. Boyle, Isaline Renard, Saul Michue-Seijas, Harry C. Sample, Graeme J. Stasiuk, Benjamin P. Burke
Publikováno v:
Chemical Communications. 56:11090-11093
The goal of “personalised” medicine has seen a growing interest in the development of theranostic agents. Bifunctional, and targeted-trifunctional, theranostic water-soluble porphyrins with a histidine-like chelating group have been synthesised v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb6bdd989aa7061bfbabad8df8a4711
https://doi.org/10.1039/d0cc03958f
https://doi.org/10.1039/d0cc03958f
Publikováno v:
Photochemical & Photobiological Sciences. 18:495-504
The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13–BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fc5b250229096d0cb5cdc89ce9eb761
https://doi.org/10.1039/c8pp00402a
https://doi.org/10.1039/c8pp00402a
Publikováno v:
Chembiochem : a European journal of chemical biology. 22(5)
In this study, we report for the first time the successful immobilization of a known cytoactive [Ru(η6-arene)(C2O4)PTA] (RAPTA) complex to a biologically inert polyacrylamide nanoparticle support. The nanoparticles have been characterised by zetasiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb25460e13e6d842c12d84c73077f5d1
https://pubmed.ncbi.nlm.nih.gov/33095468
https://pubmed.ncbi.nlm.nih.gov/33095468
Publikováno v:
Molecules
Volume 25
Issue 2
Molecules, Vol 25, Iss 2, p 244 (2020)
Volume 25
Issue 2
Molecules, Vol 25, Iss 2, p 244 (2020)
Metallation of biomacromolecular species forms the basis for the anticancer activity of many metallodrugs. A major limitation of these compounds is that their reactivity is indiscriminate and can, in principle, occur in healthy tissue as well as canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6541f12c45a44a765fdd0fb4ce5675e2
Autor:
Steven Y. Yap, Huguette Savoie, Aline Nonat, Ross W. Boyle, Thomas W. Price, Graeme J. Stasiuk, Raphaël Gillet, Loïc J. Charbonnière
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, ⟨10.1002/chem.201905776⟩
Price, T, Yap, S, Gillet, R, Savoie, H, Charbonnière, L, Boyle, R, Nonat, A & Stasiuk, G J 2020, ' Evaluation of a bispidine-based chelator for gallium-68 and of the porphyrin conjugate as PET/PDT theranostic agent ', Chemistry (Weinheim an der Bergstrasse, Germany), vol. 26, no. 34, pp. 7602-7608 . https://doi.org/10.1002/chem.201905776
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, ⟨10.1002/chem.201905776⟩
Price, T, Yap, S, Gillet, R, Savoie, H, Charbonnière, L, Boyle, R, Nonat, A & Stasiuk, G J 2020, ' Evaluation of a bispidine-based chelator for gallium-68 and of the porphyrin conjugate as PET/PDT theranostic agent ', Chemistry (Weinheim an der Bergstrasse, Germany), vol. 26, no. 34, pp. 7602-7608 . https://doi.org/10.1002/chem.201905776
International audience; In this study a bispidine ligand has been applied to the complexation of gallium(III) and radiolabelled with gallium-68 for the first time. Despite its 5-coordinate nature, the resulting complex is stable in serum for over two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f172f6532dfcec3b5b59a162ea78dd0c
https://hal.archives-ouvertes.fr/hal-02870103
https://hal.archives-ouvertes.fr/hal-02870103
Publikováno v:
Organometallics. 37:294-297
The pH-dependent intramolecular chelation of a tethered sulfonamide ligand in ruthenium(II) arene complexes is demonstrated, a process shown to modulate metal-centered reactivity toward the model ligand guanosine 5′-monophosphate within the physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1873261fe850c26e0abd886b56573709
https://doi.org/10.1021/acs.organomet.7b00868
https://doi.org/10.1021/acs.organomet.7b00868
Autor:
Miffy. H. Y. Cheng, Vijay Chudasama, Francesca Bryden, João M. M. Rodrigues, Huguette Savoie, Ross W. Boyle, Andrew Beeby, Antoine Maruani
Publikováno v:
Bioconjugate chemistry, 2018, Vol.29(1), pp.176-181 [Peer Reviewed Journal]
Exploitation of photosensitizers as payloads for antibody-based anticancer therapeutics offers a novel alternative to the small pool of commonly utilized cytotoxins. However, existing bioconjugation methodologies are incompatible with the requirement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e759163cbc2c4a1dfd8af356cce81aa2
https://doi.org/10.1021/acs.bioconjchem.7b00678
https://doi.org/10.1021/acs.bioconjchem.7b00678