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Akademický článek

Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation

Autor: Rachel E. Stamateris, Huguet V. Landa-Galvan, Rohit B. Sharma, Christine Darko, David Redmond, Sushil G. Rane, Laura C. Alonso

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)

Expanding β cell mass is a critical goal in the fight against diabetes. CDK4, an extensively characterized cell cycle activator, is required to establish and maintain β cell number. β cell failure in the IRS2-deletion mouse type 2 diabetes model i

Externí odkaz: https://doaj.org/article/432b8a2379a0464cb5ac53497221f766

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Akademický článek

Metabolic syndrome diminishes insulin-induced Akt activation and causes a redistribution of Akt-interacting proteins in cardiomyocytes.

Autor: Huguet V Landa-Galvan, Emmanuel Rios-Castro, Tatiana Romero-Garcia, Angelica Rueda, Jesus Alberto Olivares-Reyes

Publikováno v: PLoS ONE, Vol 15, Iss 1, p e0228115 (2020)

Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors, with insulin resistance as a critical component for its development. Insulin signaling in the heart leads to Akt (also known as PKB) activation, a serine/threonine protein kinase

Externí odkaz: https://doaj.org/article/a5a62f988542496690e81c61f7abe41f

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Akademický článek

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Akademický článek

Metabolic syndrome diminishes insulin-induced Akt activation and causes a redistribution of Akt-interacting proteins in cardiomyocytes.

Autor: Landa-Galvan, Huguet V.¹ (AUTHOR), Rios-Castro, Emmanuel² (AUTHOR), Romero-Garcia, Tatiana¹ (AUTHOR), Rueda, Angelica¹ (AUTHOR) jolivare@cinvestav.mx, Olivares-Reyes, Jesus Alberto¹ (AUTHOR) jolivare@cinvestav.mx

Publikováno v: PLoS ONE. 1/29/2020, Vol. 15 Issue 1, p1-25. 25p.

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Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells

Autor: Rohit Sharma, Huguet V. Landa-Galván, Laura C. Alonso

Publikováno v: Diabetes

Type 2 diabetes (T2D) is a growing cause of poor health, psychosocial burden, and economic costs worldwide. The pancreatic β-cell is a cornerstone of metabolic physiology. Insulin deficiency leads to hyperglycemia, which was fatal before the availab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d107430e83123182f15d547a09b19d17
https://doi.org/10.2337/dbi20-0033

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Akademický článek

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Angiotensin II Inhibits Insulin Receptor Signaling in Adipose Cells

Autor: Citlaly Gutierrez-Rodelo, Araceli Arellano-Plancarte, Judith Hernandez-Aranda, Huguet V. Landa-Galvan, G. Karina Parra-Mercado, Nicole J. Moreno-Licona, Karla D. Hernandez-Gonzalez, Kevin J. Catt, Rafael Villalobos-Molina, J. Alberto Olivares-Reyes

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6048

Angiotensin II (Ang II) is a critical regulator of insulin signaling in the cardiovascular system and metabolic tissues. However, in adipose cells, the regulatory role of Ang II on insulin actions remains to be elucidated. The effect of Ang II on ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed14c50f0df6dcd95ab7e6e1b5b7eb7b

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