Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Hugues Loosfelt"'
Autor:
Nathalie Esber, Florian Le Billan, Michèle Resche-Rigon, Hugues Loosfelt, Marc Lombès, Nathalie Chabbert-Buffet
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140795 (2015)
The progesterone receptor (PR) with its isoforms and ligands are involved in breast tumorigenesis and prognosis. We aimed at analyzing the respective contribution of PR isoforms, PRA and PRB, in breast cancer cell proliferation in a new estrogen-inde
Externí odkaz:
https://doaj.org/article/0cb5a5152ee84565b777e549be3e825c
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45993 (2012)
Progesterone receptor isoforms (PRA and PRB) are expressed at equal levels in normal mammary cells. However, alteration in PRA/PRB expression is often observed in aggressive breast cancer suggesting differential contribution of PR isoforms in carcino
Externí odkaz:
https://doaj.org/article/1e7a0e107f264590ba094cc074ddc5fa
Autor:
Mouad Alami, Marc Lombès, Nathalie Esber, Jérôme Fagart, Hugues Loosfelt, Nathalie Chabbert-Buffet, Michèle Resche-Rigon, Clément Cherbonnier, Abdallah Hamze
Publikováno v:
Hormones and Cancer. 7:137-147
Breast cancer is a hormone-dependent disease in which estrogen signaling targeting drugs fail in about 10 % due to resistance. Strong evidences highlighted the mitogen role of progesterone, its ligands, and the corresponding progesterone receptor (PR
Autor:
Hugues Loosfelt, Nadine Binart, Lavinia Vija, Jacques Young, Geri Meduri, Say Viengchareun, Kahina Boukari, Marc Lombès
Publikováno v:
Molecular and Cellular Endocrinology. 384:32-42
Mature Sertoli cells (SC) are critical mediators of androgen regulation of spermatogenesis, via the androgen receptor (AR) signaling. Available immortalized SC lines loose AR expression or androgen responsiveness, hampering the study of endogenous AR
Autor:
Abdallah Hamze, Marie-Edith Rafestin-Oblin, Jean-Daniel Brion, Jérôme Fagart, Abdellatif Tikad, Michel Fay, Mouad Alami, Nathalie Chabbert-Buffet, Hugues Loosfelt, Larbi Amazit, Geri Meduri, Marc Lombès, Junaid Ali Khan
Publikováno v:
Molecular Endocrinology. 27:909-924
Currently available progesterone (P4) receptor (PR) antagonists, such as mifepristone (RU486), lack specificity and display partial agonist properties, leading to potential drawbacks in their clinical use. Recent x-ray crystallographic studies have i
Autor:
Hugues Loosfelt, Larbi Amazit, Anne Guiochon-Mantel, Junaid Ali Khan, Marc Lombès, Catherine Bellance
Publikováno v:
Molecular Endocrinology. 25:1710-1724
Progesterone receptor (PR) isoforms (PRA and PRB) are implicated in the progression of breast cancers frequently associated with imbalanced PRA/PRB expression ratio. Antiprogestins represent potential antitumorigenic agents for such hormone-dependent
Autor:
Leen J. Blok, Anne Chauchereau, Nathalie Chabbert-Buffet, Leila Rajhi, Marc Lombès, Hugues Loosfelt, Boris Dasen, Larbi Amazit, Anne Guiochon-Mantel, Sandra Wenk, Maria Georgiakaki, Curt W. Burger, Edwin Milgrom, Geri Meduri
Publikováno v:
Molecular Endocrinology, 20(9), 2122-2140. The Endocrine Society
Modulators of cofactor recruitment by nuclear receptors are expected to play an important role in the coordination of hormone-induced transactivation processes. To identify such factors interacting with the N-terminal domain (NTD) of the progesterone
Publikováno v:
Biology of the Cell. 96:133-144
Accumulated data suggest that endothelial cells express specific receptors for several peptide and (glyco)protein hormones that may transport hormones across the cell to be delivered to the interstitial fluid and tissue target cells. Surprisingly, ve
Autor:
Hugues Loosfelt, Larbi Amazit, Anne Chauchereau, Jacques Pantel, Edwin Milgrom, Youssef Alj, Christophe Pichon, Rakesh K. Tyagi, Anne Guiochon-Mantel, Emmanuelle Foulon-Guinchard, Philippe Leclerc
Publikováno v:
Journal of Biological Chemistry. 278:32195-32203
Steroid hormone receptors are ligand-stimulated transcription factors that modulate gene transcription by recruiting coregulators to gene promoters. Subcellular localization and dynamic movements of transcription factors have been shown to be one of
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2000, 275 (12), pp.8540-8548. ⟨10.1074/jbc.275.12.8540⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2000, 275 (12), pp.8540-8548. ⟨10.1074/jbc.275.12.8540⟩
International audience; JAB1 (Jun activation domain-binding protein-1) has previously been described as a coactivator of AP1 transcription factor. We show here, by yeast and mammalian two-hybrid analyses and by pull-down experiments, that JAB1 also i