Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Hugues Leblond"'
Autor:
Yann Develle, Hugues Leblond
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2020)
Pharmacological treatment facilitating locomotor expression will also have some effects on reflex expression through the modulation of spinal circuitry. Buspirone, a partial serotonin receptor agonist (5-HT1A), was recently shown to facilitate and ev
Externí odkaz:
https://doaj.org/article/31318f81c6604c21b7a0d1f49a378944
Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain
Autor:
Mathieu Piché, Emad Khalilzadeh, Hugues Leblond, Thierry Paquette, Benjamin Provencher, Nasim Eskandari, Hatef Khosravi
Publikováno v:
Journal of Visualized Experiments.
Low back pain is the leading cause of disability worldwide, with dramatic personal, economic, and social consequences. To develop novel therapeutics, animal models are needed to examine the mechanisms and effectiveness of novel therapies from a trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599f1061a0efdb0feafc7cb54f58dd4f
https://doi.org/10.3791/63667
https://doi.org/10.3791/63667
Publikováno v:
Pain.
Functional magnetic resonance imaging has been used to investigate nociceptive processes in patients with chronic pain. However, the results may be confounded with changes in neurovascular coupling induced by chronic pain. The objective of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d1d78daac7c5ce1c8d63c3cb2c272c
https://pubmed.ncbi.nlm.nih.gov/36036900
https://pubmed.ncbi.nlm.nih.gov/36036900
Publikováno v:
Neuroscience Research. 149:22-28
Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70680a24aeec1b05152dbe436c6818b3
https://doi.org/10.1016/j.neures.2019.01.008
https://doi.org/10.1016/j.neures.2019.01.008
Autor:
Ryota Tokunaga, Yukari Takahashi, Sara Touj, Harumi Hotta, Hugues Leblond, Fusao Kato, Mathieu Piché
Publikováno v:
European journal of pain (London, England)REFERENCES. 26(4)
Chronic primary low back pain may be associated with hyperalgesia in uninjured tissues and with decreased pain inhibition. Previous studies have shown that the amygdala is involved in pain regulation and chronic pain, that neuronal activity in the am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b75613c220e3972675ef27a3cc337d6
https://pubmed.ncbi.nlm.nih.gov/35129248
https://pubmed.ncbi.nlm.nih.gov/35129248
Publikováno v:
Neuroscience Letters. 690:36-41
Inflammation is a common comorbidity in patients with traumatic spinal cord injury (SCI). Recent reports indicate that inflammation hinders functional recovery in animal models of SCI. However, the spinal mechanisms underlying this alteration are cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221ca1a0a43f56cdd40cd293dc4ff8f2
https://doi.org/10.1016/j.neulet.2018.10.005
https://doi.org/10.1016/j.neulet.2018.10.005
Publikováno v:
The European journal of neuroscienceREFERENCES. 54(3)
Medetomidine and isoflurane are commonly used for general anaesthesia in fMRI studies, but they alter cerebral blood flow (CBF) regulation and neurovascular coupling (NVC). In addition, medetomidine induces hypoinsulinemia and hyperglycaemia, which a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2063bac8cf242b4cd5e10c2d8622ba40
https://pubmed.ncbi.nlm.nih.gov/34137097
https://pubmed.ncbi.nlm.nih.gov/34137097
Publikováno v:
The journal of physiological sciences : JPS. 71(1)
Functional magnetic resonance imaging (fMRI) of the spinal cord relies on the integrity of neurovascular coupling (NVC) to infer neuronal activity from hemodynamic changes. Astrocytes are a key component of cerebral NVC, but their role in spinal NVC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b12b22f3d31fde818ba20e32136724
https://pubmed.ncbi.nlm.nih.gov/34049480
https://pubmed.ncbi.nlm.nih.gov/34049480
Publikováno v:
Journal of Neurotrauma. 35:2208-2221
Despite efforts to potentiate spinal cord lesioned (SCL) patients' functional recovery with multi-targeted therapy combining pharmacological treatment and training, consistent improvements in locomotor control by descending transmission or spinal net
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fed325886e7f8bd9dda85bcb6cb0de
https://doi.org/10.1089/neu.2017.5476
https://doi.org/10.1089/neu.2017.5476