Novel Synthesis of IMC-48 and Affinity Evaluation with Different i-Motif DNA Sequences

Autor: Florian Berthiol, Joseph Boissieras, Hugues Bonnet, Marie Pierrot, Christian Philouze, Jean-François Poisson, Anton Granzhan, Jérôme Dejeu, Eric Defrancq

Publikováno v: Molecules, Vol 28, Iss 2, p 682 (2023)

During the last decade, the evidence for the biological relevance of i-motif DNA (i-DNA) has been accumulated. However, relatively few molecules were reported to interact with i-DNA, and a controversy concerning their binding mode, affinity, and sele

Externí odkaz: https://doaj.org/article/62ab071e462643768462809c25a0471f

Conformational transition in SPR experiments: impact of spacer length, immobilization mode and aptamer density on signal sign and amplitude

Autor: Marina Pons, Marine Perenon, Hugues Bonnet, Emilie Gillon, Celio Vallée, Liliane Coche-Guérente, Eric Defrancq, Nicolas Spinelli, Angeline Van der Heyden, Jérôme Dejeu

Publikováno v: The Analyst. 147:4197-4205

Surface plasmon resonance (SPR) is an optical, real-time and label-free technique which represents a standard to study biomolecular interactions. While SPR signals are usually positive upon recognition, a few cases of negative signals have been repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a240738ad7ada4e96fe12d433cad754
https://doi.org/10.1039/d2an00824f

Negative SPR Signals during Low Molecular Weight Analyte Recognition

Autor: Jérôme Dejeu, Nicolas Spinelli, Hugues Bonnet, Eric Defrancq, Liliane Coche-Guérente, A. Van der Heyden

Publikováno v: Analytical Chemistry
Analytical Chemistry, American Chemical Society, 2021, 93 (8), pp.4134-4140. ⟨10.1021/acs.analchem.1c00071⟩

Surface plasmon resonance (SPR) is a powerful technique for studying biomolecular interactions mainly due to its sensitivity and real-time and label free advantages. While SPR signals are usually positive, only a few studies have reported sensorgrams

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33bf4d916c33d2f4f117c2c8be04c29
https://doi.org/10.1021/acs.analchem.1c00071

Assessment of presumed small-molecule ligands of telomeric i-DNA by biolayer interferometry (BLI)

Autor: Hugues Bonnet, Maéva Morel, Alexandre Devaux, Joseph Boissieras, Anton Granzhan, Benjamin Elias, Thomas Lavergne, Jérôme Dejeu, Eric Defrancq

Publikováno v: Chemical Communications
Chemical Communications, 2022, 58 (33), pp.5116. ⟨10.1039/D2CC00836J⟩
Chemical Communications, Royal Society of Chemistry, In press, ⟨10.1039/D2CC00836J⟩

International audience; Biolayer interferometry (BLI) and circular dichroism (CD) spectroscopy were used to investigate the interaction between previously reported i-motif DNA (i-DNA) ligands and folded or unfolded i-DNA in acidic (pH 5.5) and near-n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936e439dae44480bc35ee380d2da7518
https://hal.science/hal-03632613

Exploring the structure-activity relationship of benzylidene-2,3-dihydro-1H-inden-1-one compared to benzofuran-3(2H)-one derivatives as inhibitors of tau amyloid fibers

Autor: Emeline Boukherrouba, Camille Larosa, Kim-Anh Nguyen, Jérémy Caburet, Laurent Lunven, Hugues Bonnet, Antoine Fortuné, Ahcène Boumendjel, Benjamin Boucherle, Sabine Chierici, Marine Peuchmaur

Publikováno v: European Journal of Medicinal Chemistry. 231:114139

Tauopathies, such as Alzheimer's disease, have been the subject of several hypotheses regarding the way to treat them. Hyperphosphorylation of tau protein leading to its aggregation is widely recognized as a key step in the development of these disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2e16c156cbfe284a014a89da33cc61
https://doi.org/10.1016/j.ejmech.2022.114139