Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Hugues Aschard"'
Autor:
Xiaofeng Zhu, Yihe Yang, Noah Lorincz-Comi, Gen Li, Amy R. Bentley, Paul S. de Vries, Michael Brown, Alanna C. Morrison, Charles N. Rotimi, W. James Gauderman, Dabeeru C. Rao, Hugues Aschard, the CHARGE Gene-lifestyle Interactions Working Group
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract There is a long-standing debate about the magnitude of the contribution of gene-environment interactions to phenotypic variations of complex traits owing to the low statistical power and few reported interactions to date. To address this iss
Externí odkaz:
https://doaj.org/article/66a84dd74b9247fdbe2989f4fda3077a
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Approximately 95% of samples analyzed in univariate genome-wide association studies (GWAS) are of European ancestry. This bias toward European ancestry populations in association screening also exists for other analyses and method
Externí odkaz:
https://doaj.org/article/efd13092ad5f41eea9bf565ee77456a6
Autor:
Yuka Suzuki, Hervé Ménager, Bryan Brancotte, Raphaël Vernet, Cyril Nerin, Christophe Boetto, Antoine Auvergne, Christophe Linhard, Rachel Torchet, Pierre Lechat, Lucie Troubat, Michael H. Cho, Emmanuelle Bouzigon, Hugues Aschard, Hanna Julienne
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100319- (2024)
Summary: Since the first genome-wide association studies (GWASs), thousands of variant-trait associations have been discovered. However, comprehensively mapping the genetic determinant of complex traits through univariate testing can require prohibit
Externí odkaz:
https://doaj.org/article/a4dbb25453d64cee9640add760970ad8
Autor:
Clara Albiñana, Zhihong Zhu, Andrew J. Schork, Andrés Ingason, Hugues Aschard, Isabell Brikell, Cynthia M. Bulik, Liselotte V. Petersen, Esben Agerbo, Jakob Grove, Merete Nordentoft, David M. Hougaard, Thomas Werge, Anders D. Børglum, Preben Bo Mortensen, John J. McGrath, Benjamin M. Neale, Florian Privé, Bjarni J. Vilhjálmsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The predictive performance of polygenic scores (PGS) is largely dependent on the number of samples available to train the PGS. Increasing the sample size for a specific phenotype is expensive and takes time, but this sample size can be effec
Externí odkaz:
https://doaj.org/article/65c6fd7da745423fbb7f56199da61c83
Autor:
Etienne Villain, Aurélie Chanson, Malwina Mainka, Nadja Kampschulte, Pauline Le Faouder, Justine Bertrand-Michel, Marion Brandolini-Bulon, Bruno Charbit, Munyaradzi Musvosvi, Nicole Bilek, Thomas J. Scriba, Lluis Quintana-Murci, Nils Helge Schebb, Darragh Duffy, Cécile Gladine, Laurent Abel, Andres Alcover, Hugues Aschard, Philippe Bousso, Nollaig Bourke, Petter Brodin, Pierre Bruhns, Nadine Cerf-Bensussan, Ana Cumano, Christophe D’Enfert, Ludovic Deriano, Marie-Agnès Dillies, James Di Santo, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Gunilla Karlsson Hedestam, Serge Hercberg, Molly A. Ingersoll, Olivier Lantz, Rose Anne Kenny, Mickaël Ménager, Hugo Mouquet, Cliona O'Farrelly, Etienne Patin, Sandra Pellegrini, Antonio Rausell, Frédéric Rieux-Laucat, Lars Rogge, Magnus Fontes, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Christophe Zimmer, Matthew L. Albert
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107422- (2023)
Summary: Oxylipins are major immunomodulating mediators, yet studies of inflammation focus mainly on cytokines. Here, using a standardized whole-blood stimulation system, we characterized the oxylipin-driven inflammatory responses to various stimuli
Externí odkaz:
https://doaj.org/article/197340910dcf4806952a46ee824b2e76
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background Bioinformatics investigators often gain insights by combining information across multiple and disparate data sets. Merging data from multiple sources frequently results in data sets that are incomplete or contain missing values. A
Externí odkaz:
https://doaj.org/article/9b9d0b3c12954418b849b97df21736ef
Autor:
Tristan Hoellinger, Camille Mestre, Hugues Aschard, Wilfried Le Goff, Sylvain Foissac, Thomas Faraut, Sarah Djebali
Publikováno v:
Frontiers in Bioinformatics, Vol 3 (2023)
Differences in cells’ functions arise from differential activity of regulatory elements, including enhancers. Enhancers are cis-regulatory elements that cooperate with promoters through transcription factors to activate the expression of one or sev
Externí odkaz:
https://doaj.org/article/73a3910a12624bcdb92d4c98d5247f4d
Autor:
Stéphanie Pons, Eric Frapy, Youssouf Sereme, Charlotte Gaultier, François Lebreton, Andrea Kropec, Olga Danilchanka, Laura Schlemmer, Cécile Schrimpf, Margaux Allain, François Angoulvant, Hervé Lecuyer, Stéphane Bonacorsi, Hugues Aschard, Harry Sokol, Colette Cywes-Bentley, John J. Mekalanos, Thomas Guillard, Gerald B. Pier, Damien Roux, David Skurnik
Publikováno v:
EBioMedicine, Vol 88, Iss , Pp 104439- (2023)
Summary: Background: Worldwide, Escherichia coli is the leading cause of neonatal Gram-negative bacterial meningitis, but full understanding of the pathogenesis of this disease is not yet achieved. Moreover, to date, no vaccine is available against b
Externí odkaz:
https://doaj.org/article/6072e4ffadcf4741b891307baa3891fb
Autor:
Timothy D. Majarian, Amy R. Bentley, Vincent Laville, Michael R. Brown, Daniel I. Chasman, Paul S. de Vries, Mary F. Feitosa, Nora Franceschini, W. James Gauderman, Casey Marchek, Daniel Levy, Alanna C. Morrison, Michael Province, Dabeeru C. Rao, Karen Schwander, Yun Ju Sung, Charles N. Rotimi, Hugues Aschard, C. Charles Gu, Alisa K. Manning, on behalf of the CHARGE Gene-Lifestyle Interactions Working Group
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Though both genetic and lifestyle factors are known to influence cardiometabolic outcomes, less attention has been given to whether lifestyle exposures can alter the association between a genetic variant and these outcomes. The Cohorts for Heart and
Externí odkaz:
https://doaj.org/article/52cda5d16983458c835040c49c566491
Publikováno v:
HGG Advances, Vol 3, Iss 4, Pp 100136- (2022)
Summary: Publicly available genome-wide association studies (GWAS) summary statistics exhibit uneven quality, which can impact the validity of follow-up analyses. First, we present an overview of possible misspecifications that come with GWAS summary
Externí odkaz:
https://doaj.org/article/422e9b5d08034812845b0a504ffe9136