Zobrazeno 1 - 10
of 337
pro vyhledávání: '"Hugues, de Thé"'
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Adult T cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic infection with human T cell leukemia virus type 1 (HTLV-1). The viral oncoprotein Tax initiates T cell transformation through activation of critical cellul
Externí odkaz:
https://doaj.org/article/618a02dc590d4d0784a57c15cd5c3098
Autor:
Sarah Tessier, Omar Ferhi, Marie-Claude Geoffroy, Román González-Prieto, Antoine Canat, Samuel Quentin, Marika Pla, Michiko Niwa-Kawakita, Pierre Bercier, Domitille Rérolle, Pierre Therizols, Emmanuelle Fabre, Alfred C. O. Vertegaal, Hugues de Thé, Valérie Lallemand-Breitenbach
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here the authors identify novel PML-partners and demonstrate that PML NBs control their sumoylation and that PML-controlled sumoylation of transcriptional regulators maintains the embryonic stem cell transcriptome and transposable element silencing.
Externí odkaz:
https://doaj.org/article/5fa232a562fb4fdfab6f62d5a90021c8
Zbtb14 regulates monocyte and macrophage development through inhibiting pu.1 expression in zebrafish
Publikováno v:
eLife, Vol 11 (2022)
Macrophages and their precursor cells, monocytes, are the first line of defense of the body against foreign pathogens and tissue damage. Although the origins of macrophages are diverse, some common transcription factors (such as PU.1) are required to
Externí odkaz:
https://doaj.org/article/0d16a292df88445a9a83f42ab85036b4
Akademický článek
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Autor:
Ambroise Marçais, Lucy Cook, Aviva Witkover, Vahid Asnafi, Véronique Avettand-Fenoel, Richard Delarue, Morgane Cheminant, David Sibon, Laurent Frenzel, Hugues de Thé, Charles R. M. Bangham, Ali Bazarbachi, Olivier Hermine, Felipe Suarez
Publikováno v:
Retrovirology, Vol 17, Iss 1, Pp 1-5 (2020)
Abstract Background Adult T-cell leukemia-lymphoma (ATL) is an aggressive mature lymphoid proliferation associated with poor prognosis. Standard of care includes chemotherapy and/or the combination of zidovudine and interferon-alpha. However, most pa
Externí odkaz:
https://doaj.org/article/2211416374c74375b355614cb005980f
Autor:
Sarah Tessier, Omar Ferhi, Marie-Claude Geoffroy, Román González-Prieto, Antoine Canat, Samuel Quentin, Marika Pla, Michiko Niwa-Kawakita, Pierre Bercier, Domitille Rérolle, Marilyn Tirard, Pierre Therizols, Emmanuelle Fabre, Alfred C. O. Vertegaal, Hugues de Thé, Valérie Lallemand-Breitenbach
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/43bf9cc247ef4f48ab070961d4555b8d
Autor:
Shuo Gao, Zixuan Wang, Luxiang Wang, Haihong Wang, Hao Yuan, Xiaohui Liu, Saijuan Chen, Zhu Chen, Hugues de Thé, Wenqing Zhang, Yiyue Zhang, Jun Zhu, Jun Zhou
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009693 (2021)
The ubiquitin-proteasome system plays important roles in various biological processes as it degrades the majority of cellular proteins. Adequate proteasomal degradation of crucial transcription regulators ensures the proper development of neutrophils
Externí odkaz:
https://doaj.org/article/074e248f45494816a93de01799d651a8
Loss of interleukin-10 activates innate immunity to eradicate adult T-cell leukemia-initiating cells
Autor:
Hiba El Hajj, Rita Hleihel, Marwan El Sabban, Julie Bruneau, Ghazi Zaatari, Morgane Cheminant, Ambroise Marçais, Abdou Akkouche, Hideki Hasegawa, William Hall, Hugues De Thé, Olivier Hermine, Ali Bazarbachi
Publikováno v:
Haematologica, Vol 106, Iss 5 (2021)
Adult T cell leukemia/lymphoma (ATL) is associated to chronic human T cell leukemia virus type 1 (HTLV-1) infection and carries a poor prognosis. Arsenic trioxide (AS) and interferon-alpha (IFNα) together selectively trigger Tax viral oncoprotein de
Externí odkaz:
https://doaj.org/article/db01ad50a91e487a93b2afd61a494581
Publikováno v:
Cells, Vol 11, Iss 5, p 814 (2022)
Sumoylation is an essential post-translational modification that has evolved to regulate intricate networks within emerging complexities of eukaryotic cells. Thousands of target substrates are modified by SUMO peptides, leading to changes in protein
Externí odkaz:
https://doaj.org/article/f1aafc83e77b4a0fba7dd6938e156105
Autor:
Juliette Humeau, Allan Sauvat, Giulia Cerrato, Wei Xie, Friedemann Loos, Francesca Iannantuoni, Lucillia Bezu, Sarah Lévesque, Juliette Paillet, Jonathan Pol, Marion Leduc, Laurence Zitvogel, Hugues de Thé, Oliver Kepp, Guido Kroemer
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 5, Pp n/a-n/a (2020)
Abstract Chemotherapy still constitutes the standard of care for the treatment of most neoplastic diseases. Certain chemotherapeutics from the oncological armamentarium are able to trigger pre‐mortem stress signals that lead to immunogenic cell dea
Externí odkaz:
https://doaj.org/article/9ac05f98dda3489daa122aa6f33d4ae1