Výsledky vyhledávání - "Hugues, Gascan"

Akademický článek

Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease

Autor: Alain Trautmann, Hugues Gascan, Raouf Ghozzi

Publikováno v: Frontiers in Medicine, Vol 7 (2020)

Recently, disulfiram has been proposed as a promising treatment for people suffering from persistent symptoms of Lyme Disease. Disulfiram has several distinct molecular targets. The most well-known is alcohol dehydrogenase, a key enzyme for detoxifyi

Externí odkaz: https://doaj.org/article/a3586480418e497a88c25e9c763ad44a

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Akademický článek

Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis

Autor: Virginie Carrière, Muhammad Imran Arshad, Jacques Le Seyec, Benjamin Lefevre, Muhammad Farooq, Aurélien Jan, Christelle Manuel, Laurence Touami-Bernard, Catherine Lucas-Clerc, Valentine Genet, Hugues Gascan, Jean-Philippe Girard, Frédéric Chalmel, Lucie Lamontagne, Claire Piquet-Pellorce, Michel Samson

Publikováno v: Mediators of Inflammation, Vol 2017 (2017)

The alarmin IL-33 has been described to be upregulated in human and murine viral hepatitis. However, the role of endogenous IL-33 in viral hepatitis remains obscure. We aimed to decipher its function by infecting IL-33-deficient mice (IL-33 KO) and t

Externí odkaz: https://doaj.org/article/9fe8ff11580440da92d3947ef6e69c6e

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Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease

Autor: Raouf Ghozzi, Hugues Gascan, Alain Trautmann

Publikováno v: Frontiers in Medicine, Vol 7 (2020)
Frontiers in Medicine
Frontiers in Medicine, 2020, 7, pp.133. ⟨10.3389/fmed.2020.00133⟩
Frontiers in Medicine, Frontiers media, 2020, 7, pp.133. ⟨10.3389/fmed.2020.00133⟩

International audience; Recently, disulfiram has been proposed as a promising treatment for people suffering from persistent symptoms of Lyme Disease. Disulfiram has several distinct molecular targets. The most well-known is alcohol dehydrogenase, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be93a2660aa661ddb20ea24ffeaaef28
https://www.frontiersin.org/article/10.3389/fmed.2020.00133/full

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Akademický článek

Invariant NKT cells drive hepatic cytokinic microenvironment favoring efficient granuloma formation and early control of Leishmania donovani infection.

Autor: Florence Robert-Gangneux, Anne-Sophie Drogoul, Octavie Rostan, Claire Piquet-Pellorce, Jérome Cayon, Mariette Lisbonne, André Herbelin, Hugues Gascan, Claude Guiguen, Michel Samson, Jean-Pierre Gangneux

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33413 (2012)

The development of inflammatory granulomas around infected Kupffer cells is necessary for hepatic parasite clearance during visceral leishmaniasis. Invariant NKT (iNKT) cells are predominant T cells in the mouse liver and can synthesize large quantit

Externí odkaz: https://doaj.org/article/5b6383e8b2a6453d9da71da97c2b2030

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Interleukin-27 and IFNγ regulate the expression of CXCL9, CXCL10, and CXCL11 in hepatitis

Autor: Yannic Danger, Laetitia Basset, Hugues Gascan, Michel Samson, Muhammad Imran Arshad, Claire Piquet-Pellorce, Sylvie Chevalier

Publikováno v: Journal of Molecular Medicine
Journal of Molecular Medicine, 2015, 93 (12), pp.1355-1367. ⟨10.1007/s00109-015-1319-6⟩
Journal of Molecular Medicine, Springer Verlag, 2015, 93 (12), pp.1355-1367. 〈10.1007/s00109-015-1319-6〉
Journal of Molecular Medicine, Springer Verlag, 2015, 93 (12), pp.1355-1367. ⟨10.1007/s00109-015-1319-6⟩

International audience; Unlabelled - Interleukin-27 (IL-27) belongs to the IL-6/IL-12 family of cytokines, associated with different inflammatory diseases and orchestrates its biological activity via common heterodimeric receptor composed of WSX-1 (I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fa1a1acad115d6fb810225119f39ac
https://doi.org/10.1007/s00109-015-1319-6

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Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling

Autor: Emmanuelle David, François Rédini, Bénédicte Brounais, Carl D. Richards, Frédéric Blanchard, Régis Brion, Joel Delecrin, Sylvie Chevalier, Dominique Heymann, Pierre J. Guihard, Yannic Danger, Hugues Gascan

Publikováno v: Stem Cells / Stem Cells (Miamisburg)
Stem Cells / Stem Cells (Miamisburg), Alphamed Press, 2012, 30 (4), pp.762-72. ⟨10.1002/stem.1040⟩

Bone resorption by osteoclasts and bone formation by osteoblasts are tightly coupled processes implicating factors in TNF, bone morphogenetic protein, and Wnt families. In osteoimmunology, macrophages were described as another critical cell populatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ce0fba337e20ea2e2a96faaad0df86
https://doi.org/10.1002/stem.1040

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Molecular Dissection of Human Interleukin-31-mediated Signal Transduction through Site-directed Mutagenesis

Autor: Hugues Gascan, Fabien Barbier, Yannic Danger, François Rousseau, Sylvie Chevalier, Sabine Le Saux, Josy Froger, Elisa Ravon, Linda Grimaud

Publikováno v: Journal of Biological Chemistry. 285:3470-3477

Interleukin (IL)-31 is a recently described cytokine, preferentially produced by T helper 2 lymphocytes and associated with skin diseases, such as atopic dermatitis. IL-31 is a member of the four alpha-helix bundle cytokine family and is related to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf63ee22c548ab92d9848c99dcd8e6e
https://doi.org/10.1074/jbc.m109.049189

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Interleukin-33 overexpression is associated with liver fibrosis in mice and humans

Autor: Annie L'Helgoualc'h, Mariette Lisbonne, Hugues Gascan, Michel Rauch, Katia Bourd-Boittin, Nathalie Théret, Bruno Turlin, Claire Piquet-Pellorce, Michel Samson, Pierrick Marvie, Laurence Preisser

Publikováno v: Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine, Wiley Open Access, 2010, 14 (6B), pp.1726-39. ⟨10.1111/j.1582-4934.2009.00801.x⟩
Journal of Cellular and Molecular Medicine, 2010, 14 (6B), pp.1726-39. ⟨10.1111/j.1582-4934.2009.00801.x⟩

International audience; Interleukin-33 (IL-33), the most recently identified member of the IL-1 family, induces synthesis of T Helper 2 (Th2)-type cytokines via its heterodimeric ST2/IL-1RAcP receptor. Th2-type cytokines play an important role in fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9086df8539c7c19aa7e9779d113e42dd
https://doi.org/10.1111/j.1582-4934.2009.00801.x

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