The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibition

Autor: Irantzu Anzar, Brandon Malone, Pubudu Samarakoon, Ioannis Vardaxis, Boris Simovski, Hugues Fontenelle, Leonardo A. Meza-Zepeda, Richard Stratford, Emily Z. Keung, Melissa Burgess, Hussein A. Tawbi, Ola Myklebost, Trevor Clancy

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionSarcomas are comprised of diverse bone and connective tissue tumors with few effective therapeutic options for locally advanced unresectable and/or metastatic disease. Recent advances in immunotherapy, in particular immune checkpoint inhi

Externí odkaz: https://doaj.org/article/53e7fb56ac8c4288a24bd58dd3d4124a

Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2 leading to universal blueprints for vaccine designs

Autor: Trevor Clancy, Simen Tennøe, Richard Stratford, Jenny-Ann Malmberg, Brandon Malone, Jun Cheng, Ioannis Vardaxis, Clément Moliné, Hugues Fontenelle, Boris Simovski, Marius Gheorghe

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific reports, 10:22375
Scientific Reports

The global population is at present suffering from a pandemic of Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The goal of this study was to use artificial intellige

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a20b5ef9f78f2583d585dc5233440d0
https://doaj.org/article/b6083f2efc1b428fbf2eba0c45005e9d

Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function

Autor: Alice Gustavsen, Robert Rieben, Helge Skulstad, Frédéric Courivaud, Tom Eirik Mollnes, Miles A. Nunn, Anjan K. Bongoni, Alain Despont, Andreas Barratt-Due, Hugues Fontenelle, Helge Scott, Tor Inge Tønnessen, Søren Erik Pischke, Kjetil H. Egge, Hilde Lang Orrem

Publikováno v: 112:20
Basic Research in Cardiology
Pischke, Soeren E; Gustavsen, A; Orrem, H L; Egge, K H; Courivaud, F; Fontenelle, H; Despont, Alain; Bongoni, A K; Rieben, Robert; Tønnessen, T I; Nunn, M A; Scott, H; Skulstad, H; Barratt-Due, A; Mollnes, T E (2017). Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function. Basic research in cardiology, 112(3), p. 20. Springer-Medizin-Verlag 10.1007/s00395-017-0610-9

Source at: http://doi.org/10.1007/s00395-017-0610-9. Licensed CC BY-NC-ND 4.0. Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no benefit was found in clinical studies. Due to lack of cross-reactivity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59866a7d7fe4e7287ceb332912116e42
https://hdl.handle.net/11250/2465089

Imaging the cerebral blood flow with enhanced laser speckle contrast analysis (eLASCA) by monotonic point transformation

Autor: Minheng Li, Shanbao Tong, Anastasios Bezerianos, Yihong Qiu, Hugues Fontenelle, Peng Miao

Publikováno v: IEEE transactions on bio-medical engineering. 56(4)

Laser speckle contrast analysis (LASCA) has been demonstrated as a full-field method for imaging the cerebral blood flow (CBF). However, conventional LASCA is limited to extremely low dynamic range because of the ambient background field, dark curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d1c5f710db6181d1b74a889a72e252
https://pubmed.ncbi.nlm.nih.gov/19272894

A tutorial platform suitable for surgical simulator training (SimMentor)

Autor: Jan Sigurd, Røtnes, Johannes, Kaasa, Geir, Westgaard, Eivind Myrold, Eriksen, Per Oyvind, Hvidsten, Kyrre, Strøm, Vidar, Sørhus, Yvon, Halbwachs, Einar, Haug, Morten, Grimnes, Hugues, Fontenelle, Tom, Ekeberg, Jan B, Thomassen, Ole Jakob, Elle, Erik, Fosse

Publikováno v: Studies in health technology and informatics. 85

The introduction of simulators in surgical training entails the need to develop pedagogic platforms adapted to the potentials and limitations provided by the information technology. As a solution to the technical challenges in treating all possible i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::258294f73e280c03966817269d441841
https://pubmed.ncbi.nlm.nih.gov/15458125