Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Hugo van Ingen"'
Autor:
Agnes Adler, Mamata Bangera, J. Wouter Beugelink, Salima Bahri, Hugo van Ingen, Carolyn A. Moores, Marc Baldus
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Microtubules (MTs) are key components of the eukaryotic cytoskeleton and are essential for intracellular organization, organelle trafficking and mitosis. MT tasks depend on binding and interactions with MT-associated proteins (MAPs). MT-asso
Externí odkaz:
https://doaj.org/article/25e71f6d2a9d4f5087103ea757155034
Autor:
Imke Rudnik-Jansen, Jie Du, Nina Karssemakers-Degen, Anna R. Tellegen, Parvesh Wadhwani, Daniele Zuncheddu, Björn P. Meij, Jens Thies, Pieter Emans, Fetullah C. Öner, George Mihov, Joao Pedro Garcia, Anne S. Ulrich, Sibylle Grad, Marianna A. Tryfonidou, Hugo van Ingen, Laura B. Creemers
Publikováno v:
Drug Delivery, Vol 31, Iss 1 (2024)
Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enab
Externí odkaz:
https://doaj.org/article/e74ff26b3ae344bf99b69a5fc7b3d7c3
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The nucleosome surface contains an area with negative electrostatic potential known as the acidic patch, which functions as a binding platform for various proteins to regulate chromatin biology. The dense clustering of acidic residues may im
Externí odkaz:
https://doaj.org/article/544c1de6121f412da6043bec52db0a82
Autor:
Francesca Cantini, Paola Giannì, Sara Bobone, Cassandra Troiano, Hugo van Ingen, Renato Massoud, Nicoletta Perini, Luciana Migliore, Philippe Savarin, Charles Sanders, Lorenzo Stella, Marco Sette
Publikováno v:
Membranes, Vol 13, Iss 3, p 365 (2023)
(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabroli
Externí odkaz:
https://doaj.org/article/ebc10c2dbfd54507a807bb77133d0833
Autor:
Velten Horn, Michael Uckelmann, Heyi Zhang, Jelmer Eerland, Ivette Aarsman, Ulric B. le Paige, Chen Davidovich, Titia K. Sixma, Hugo van Ingen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Ubiquitination of histone H2A can occur on distinct lysine residues, but how each site is recognised by the specific E3 ligase remains poorly understood. Here the authors demonstrate that the E3 ligase RNF168 binds the acidic patch on the nucleosome
Externí odkaz:
https://doaj.org/article/3e125f2b63794fa29d89db5f5520deba
Autor:
Robbert Q. Kim, Paul P. Geurink, Monique P. C. Mulder, Alexander Fish, Reggy Ekkebus, Farid El Oualid, Willem J. van Dijk, Duco van Dalen, Huib Ovaa, Hugo van Ingen, Titia K. Sixma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Deubiquitinating enzymes (DUBs) are critical regulators of cellular processes by removing ubiquitin from specific targets. Here global kinetic modelling reveals the mechanism by which the low intrinsic activity of USP7 is substantially enhanced on a
Externí odkaz:
https://doaj.org/article/822bd4cb8eb04f3199afc82488ed53d3
Autor:
Kaian Teles, Vinicius Fernandes, Isabel Silva, Manuela Leite, Cesar Grisolia, Vincenzo R. Lobbia, Hugo van Ingen, Rodrigo Honorato, Paulo Lopes-de-Oliveira, Werner Treptow, Guilherme Santos
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 123, Iss , Pp 109805- (2020)
Externí odkaz:
https://doaj.org/article/b4dedf594d464f86bc6fe4094c6481f1
Autor:
Kaian Teles, Vinicius Fernandes, Isabel Silva, Manuela Leite, Cesar Grisolia, Vincenzo R. Lobbia, Hugo van Ingen, Rodrigo Honorato, Paulo Lopes-de-Oliveira, Werner Treptow, Guilherme Santos
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 121, Iss , Pp 109678- (2020)
Chromatin state is highly dependent on the nucleosome binding proteins. Herein, we used a multipronged approach employing biophysical and in vivo experiments to characterize the effects of Nucleosome Binding Peptides (NBPeps) on nucleosome and cell a
Externí odkaz:
https://doaj.org/article/dd0cf97e1e644d04a9efe214f406eacb
Publikováno v:
Molecules, Vol 25, Iss 21, p 4951 (2020)
Targeting of proteins in the histone modification machinery has emerged as a promising new direction to fight disease. The search for compounds that inhibit proteins that readout histone modification has led to several new epigenetic drugs, mostly fo
Externí odkaz:
https://doaj.org/article/55042f92cfac46e0b5b78eeaab29e99c
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007582 (2018)
The genomes of all organisms throughout the tree of life are compacted and organized in chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which are assembled on the genome into octamers, yielding nucleosomes. Post-tr
Externí odkaz:
https://doaj.org/article/3eb68035816841478250e8f736b1533b