Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hugo Wu"'
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Stem-cell-derived therapy is a promising option for tissue regeneration. Human iPSC-derived progenitors of smooth muscle cells (pSMCs) exhibit limited proliferation and differentiation, which minimizes the risk of tumor formation
Externí odkaz:
https://doaj.org/article/ceb20e69da444bb687a2fcf7722516f2
Autor:
Stefania Bottardi, Taylorjade Layne, Ailyn C. Ramòn, Norreen Quansah, Hugo Wurtele, El Bachir Affar, Eric Milot
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Inflammation control is critical during the innate immune response. Such response is triggered by the detection of molecules originating from pathogens or damaged host cells by pattern-recognition receptors (PRRs). PRRs subsequently initiate intra-ce
Externí odkaz:
https://doaj.org/article/32d3186ae4374b99a2993f199c97786d
Autor:
Maïlyn Yates, Isabelle Marois, Edlie St-Hilaire, Daryl A Ronato, Billel Djerir, Chloé Brochu, Théo Morin, Ian Hammond-Martel, Sari Gezzar-Dandashi, Lisa Casimir, Elliot Drobetsky, Laurent Cappadocia, Jean-Yves Masson, Hugo Wurtele, Alexandre Maréchal
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002552 (2024)
Impediments in replication fork progression cause genomic instability, mutagenesis, and severe pathologies. At stalled forks, RPA-coated single-stranded DNA (ssDNA) activates the ATR kinase and directs fork remodeling, 2 key early events of the repli
Externí odkaz:
https://doaj.org/article/7a96143210c043db9c56e93cd5ee4106
Autor:
Maxime Uriarte, Nadine Sen Nkwe, Roch Tremblay, Oumaima Ahmed, Clémence Messmer, Nazar Mashtalir, Haithem Barbour, Louis Masclef, Marion Voide, Claire Viallard, Salima Daou, Djaileb Abdelhadi, Daryl Ronato, Mohammadjavad Paydar, Anaïs Darracq, Karine Boulay, Nicolas Desjardins-Lecavalier, Przemyslaw Sapieha, Jean-Yves Masson, Mikhail Sergeev, Benjamin H. Kwok, Laura Hulea, Frédérick A. Mallette, Eric Milot, Bruno Larrivée, Hugo Wurtele, El Bachir Affar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Upon starvation, cells coordinate protein disposal to recycle amino acids, although the role of the proteasome has been unclear. Here, the authors show that in the mammalian nucleus, proteasomes form condensates that dissolve following nutrient reple
Externí odkaz:
https://doaj.org/article/b50e1f83646949fdb482fa1c4a35c9f5
Autor:
Jean-François Lemay, Edlie St-Hilaire, Daryl A Ronato, Yuandi Gao, François Bélanger, Sari Gezzar-Dandashi, Aimé Boris Kimenyi Ishimwe, Christina Sawchyn, Dominique Lévesque, Mary McQuaid, François-Michel Boisvert, Frédérick A Mallette, Jean-Yves Masson, Elliot A Drobetsky, Hugo Wurtele
Publikováno v:
PLoS Biology, Vol 20, Iss 10, p e3001543 (2022)
Helix-destabilizing DNA lesions induced by environmental mutagens such as UV light cause genomic instability by strongly blocking the progression of DNA replication forks (RFs). At blocked RF, single-stranded DNA (ssDNA) accumulates and is rapidly bo
Externí odkaz:
https://doaj.org/article/a406ab3b3aab4c1790f2cb75bdd9eeda
Autor:
Mary E. McQuaid, Kashif Ahmed, Stephanie Tran, Justine Rousseau, Ranad Shaheen, Kristin D. Kernohan, Kyoko E. Yuki, Prerna Grover, Ema S. Dreseris, Sameen Ahmed, Lucie Dupuis, Jennifer Stimec, Mary Shago, Zuhair N. Al-Hassnan, Roch Tremblay, Philipp G. Maass, Michael D. Wilson, Eyal Grunebaum, Kym M. Boycott, François-Michel Boisvert, Sateesh Maddirevula, Eissa A. Faqeih, Fahad Almanjomi, Zaheer Ullah Khan, Fowzan S. Alkuraya, Philippe M. Campeau, Peter Kannu, Eric I. Campos, Hugo Wurtele
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
The eukaryotic CDC45/MCM2-7/GINS (CMG) helicase unwinds the DNA double helix during DNA replication. The GINS subcomplex is required for helicase activity and is, therefore, essential for DNA replication and cell viability. Here, we report the identi
Externí odkaz:
https://doaj.org/article/3826d777770e43a3ada9bdd9c34ba315
Autor:
Abed El-Hakim El-Kadiry, Jamilah Abusarah, Yun Emma Cui, Nehme El-Hachem, Ian Hammond-Martel, Hugo Wurtele, Sini Thomas, Maryam Ahmadi, Mohammad Balood, Sébastien Talbot, Moutih Rafei
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Phenotypic screening is an ideal strategy for the discovery of novel bioactive molecules. Using a customized high-throughput screening (HTS) assay employing primary T lymphocytes, we screened a small library of 4,398 compounds with unknown biological
Externí odkaz:
https://doaj.org/article/26996bf7a38c453a815cdd4e44246a56
Autor:
Loïc Binan, François Bélanger, Maxime Uriarte, Jean François Lemay, Jean Christophe Pelletier De Koninck, Joannie Roy, El Bachir Affar, Elliot Drobetsky, Hugo Wurtele, Santiago Costantino
Publikováno v:
eLife, Vol 8 (2019)
The ability to isolate rare live cells within a heterogeneous population based solely on visual criteria remains technically challenging, due largely to limitations imposed by existing sorting technologies. Here, we present a new method that permits
Externí odkaz:
https://doaj.org/article/537e4cd9b73c45eb9749faa532d5e2a4
Publikováno v:
PLoS Genetics, Vol 14, Iss 4, p e1007356 (2018)
The evolutionarily-conserved sirtuin family of histone deacetylases regulates a multitude of DNA-associated processes. A recent genome-wide screen conducted in the yeast Saccharomyces cerevisiae identified Yku70/80, which regulate nonhomologous end-j
Externí odkaz:
https://doaj.org/article/1b5c459e2f5a468f82fcda988cbdfaf4
pH-Dependant Antifungal Activity of Valproic Acid against the Human Fungal Pathogen Candida albicans
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Current antifungal drugs suffer from limitations including toxicity, the emergence of resistance and decreased efficacy at low pH that are typical of human vaginal surfaces. Here, we have shown that the antipsychotic drug valproic acid (VPA) exhibite
Externí odkaz:
https://doaj.org/article/6132472c8092429d9de5e81e7ebf83cf