Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hugo W. Huth"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
The capacity of tumor cells to shift dynamically between different states could be responsible for chemoresistance and has been commonly linked to the acquisition of stem cell properties. Here, we have evaluated the phenotype switching associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3c24b400f73f0259ccf76b2a61fb57
https://doi.org/10.1038/s41598-021-96449-7
https://doi.org/10.1038/s41598-021-96449-7
BackgroundThe adaptation capacity of tumor cells to shift dynamically between different states could be responsible for chemoresistance and has been commonly linked to the acquisition of stem cell properties. Here, we have provided new elements conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7726005910471f6bf5a3b3fe961677be
https://doi.org/10.21203/rs.3.rs-109614/v1
https://doi.org/10.21203/rs.3.rs-109614/v1
Publikováno v:
Cellular Signalling. 28:1283-1291
The Ras-Raf-MEK-ERK1/2 signaling pathway regulates fundamental processes in malignant cells. However, the exact contributions of MEK1 and MEK2 to the development of cancer remain to be established. We studied the effects of MEK small-molecule inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da113aae2c95ba69c027d2207eeb458e
https://doi.org/10.1016/j.cellsig.2016.05.009
https://doi.org/10.1016/j.cellsig.2016.05.009
Autor:
Catherine Ropert, Hugo W. Huth
Publikováno v:
Molecular Oncology: Underlying Mechanisms and Translational Advancements ISBN: 9783319530819
The mitogen-activated protein kinases (MAPKs) belong to a family of serine/threonine kinases which transduce the signals by post-translational modifications of different downstream effectors and transcription factors involved in different aspects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f45ac83b28679646d120e3c0a54e956a
https://doi.org/10.1007/978-3-319-53082-6_3
https://doi.org/10.1007/978-3-319-53082-6_3
Autor:
Maria Elena de Lima, Jarbas M. Resende, Humberto Doriguêtto Gravina, Hugo W. Huth, Daniel Moreira dos Santos, Catherine Ropert, Alfredo M. Goes
Publikováno v:
Oncology reports. 37(4)
Tumor cells capture the signaling pathways used by normal tissue to promote their own survival and dissemination and among them, the NF-κB and MAPK pathways (ERK, JNK and p38). MAPK activation has ambiguous effects on tumor cell fate depending on ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7fb465a1d2a907b40ae07c30b7e01c3
https://pubmed.ncbi.nlm.nih.gov/28260101
https://pubmed.ncbi.nlm.nih.gov/28260101