The influence of cold temperature on cellular excitability of hippocampal networks.

Autor: Elvira de la Peña, Annika Mälkiä, Hugo Vara, Rebeca Caires, Juan J Ballesta, Carlos Belmonte, Felix Viana

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52475 (2012)

The hippocampus plays an important role in short term memory, learning and spatial navigation. A characteristic feature of the hippocampal region is its expression of different electrical population rhythms and activities during different brain state

Externí odkaz: https://doaj.org/article/70ba0231ba6f40d3a0c4f54697ea4844

Neuropathological and Motor Impairments after Incomplete Cervical Spinal Cord Injury in Pigs

Autor: Luis María Romero-Muñoz, Jorge E. Collazos-Castro, Ángel Rodríguez-De-Lope, Patricia Del Cerro, Andrés Barriga-Martín, Hugo Vara

Publikováno v: Journal of Neurotrauma

Humans, primates, and rodents with cervical spinal cord injury (SCI) show permanent sensorimotor dysfunction of the upper/forelimb as consequence of axonal damage and local neuronal death. This work aimed at characterizing a model of cervical SCI in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe0df6bcfba31648b9c732d49e73663
https://pubmed.ncbi.nlm.nih.gov/34121450

Biofunctionalized Conducting Polymer/Carbon Microfiber Electrodes for Ultrasensitive Neural Recordings

Autor: Jorge E. Collazos-Castro, Hugo Vara

Publikováno v: ACS Applied Materials & Interfaces. 7:27016-27026

Carbon microfibers (MFs) coated with conducting polymers may provide a solution for long-term recording of activity from individual or small groups of neurons. Attaching cell adhesion molecules to the electro-sensitive surface might further improve e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9eb2a02f36754ab3bf612ccd14ada14
https://doi.org/10.1021/acsami.5b09594

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease

Autor: Monica Di Luca, Alerie Guzman de la Fuente, Stefano Musardo, Barbara Borroni, Hugo Vara, Alessandro Padovani, Maurizio Giustetto, Isabel Pérez-Otaño, Silvia Pelucchi, Daniele Di Marino, Claudia Saraceno, Fabrizio Gardoni, Anna Tramontano, Elena Marcello

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2013, 123 (6), pp.2523-38. ⟨10.1172/JCI65401⟩

International audience; A disintegrin and metalloproteinase 10 (ADAM10), a disintegrin and metalloproteinase that resides in the postsynaptic densities (PSDs) of excitatory synapses, has previously been shown to limit β-amyloid peptide (Aβ) formati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1f609c34540d9af718615d6c3a7e91
https://pubmed.ncbi.nlm.nih.gov/23676497

Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease

Autor: F. Cattabeni, Alessandro Padovani, Claudia Balducci, Fabrizio Gardoni, Maurizio Giustetto, Roberta Epis, Barbara Borroni, Matteo Malinverno, Elena Marcello, Tiziana Borsello, Csaba Vastagh, Hugo Vara, Mario Dell'Agli, Gianluigi Forloni, Alessio Colombo, Monica Di Luca

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Hugo Vara [et al.]. 13 p., 7 figures and references.
We describe here an innovative, non-transgenic animal model of Alzheimer's disease. This model mimics early stages of sporadic disease, which represents the vast majority of cases. The model w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7fc5491c5c292a548fb32c1e4c4819
http://hdl.handle.net/11379/119913