Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Hugo Vanderstichele"'
Autor:
Elisabeth H. Thijssen, Inge M. W. Verberk, Jeroen Vanbrabant, Anne Koelewijn, Hans Heijst, Philip Scheltens, Wiesje van der Flier, Hugo Vanderstichele, Erik Stoops, Charlotte E. Teunissen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Plasma biomarkers that reflect specific amyloid beta (Abeta) proteoforms provide an insight in the treatment effects of Alzheimer’s disease (AD) therapies. Our aim was to develop and validate ready-to-use Simoa ‘Amyblood’ assays that m
Externí odkaz:
https://doaj.org/article/783c572408a54a5796b786b326983e7c
Autor:
François Mouton-Liger, Julien Dumurgier, Emmanuel Cognat, Claire Hourregue, Henrik Zetterberg, Hugo Vanderstichele, Eugeen Vanmechelen, Elodie Bouaziz-Amar, Kaj Blennow, Jacques Hugon, Claire Paquet
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Abstract Background The presynaptic protein neuregulin1 (NRG1) is cleaved by beta-site APP cleaving enzyme 1 (BACE1) in a similar way as amyloid precursor protein (APP) NRG1 can activate post-synaptic receptor tyrosine-protein kinase erbB4 (ErbB4) an
Externí odkaz:
https://doaj.org/article/8684adc4a477497daf12a79dafe645b7
Autor:
Niccolo Candelise, Matthias Schmitz, Katrin Thüne, Maria Cramm, Alberto Rabano, Saima Zafar, Erik Stoops, Hugo Vanderstichele, Anna Villar-Pique, Franc Llorens, Inga Zerr
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-16 (2020)
Abstract Background α-Synuclein is a small soluble protein, whose physiological function in the healthy brain is poorly understood. Intracellular inclusions of α-synuclein, referred to as Lewy bodies (LBs), are pathological hallmarks of α-synuclei
Externí odkaz:
https://doaj.org/article/ec20df70754b41958c7ca86362854b74
Autor:
Ignacio Illán‐Gala, Jordi Pegueroles, Victor Montal, Daniel Alcolea, Eduard Vilaplana, Alexandre Bejanin, Sergi Borrego‐Écija, Frederic Sampedro, Andrea Subirana, María‐Belén Sánchez‐Saudinós, Ricard Rojas‐García, Hugo Vanderstichele, Rafael Blesa, Jordi Clarimón, Anna Antonell, Albert Lladó, Raquel Sánchez‐Valle, Juan Fortea, Alberto Lleó
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 12, Pp 2518-2530 (2019)
Abstract Objective We aimed to investigate the relationship between cerebrospinal fluid levels (CSF) of amyloid precursor protein (APP)‐derived peptides related to the amyloidogenic pathway, cortical thickness, neuropsychological performance, and c
Externí odkaz:
https://doaj.org/article/16dd977f7bd94f5498d9f377021cc513
Autor:
Senthil T. Kumar, Somanath Jagannath, Cindy Francois, Hugo Vanderstichele, Erik Stoops, Hilal A. Lashuel
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105086- (2020)
Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation, and may also accumulate within LBs in Parkinson's disease (PD) and other sy
Externí odkaz:
https://doaj.org/article/6a4524a72e3b41b0bce3e7c272d97e5c
Autor:
Saima Hilal, Frank J. Wolters, Marcel M. Verbeek, Hugo Vanderstichele, M. Kamran Ikram, Erik Stoops, M. Arfan Ikram, Meike W. Vernooij
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-8 (2018)
Abstract Background Plasma amyloid-β (Aβ) levels are increasingly studied as a potential accessible marker of cognitive impairment and dementia. However, it remains underexplored whether plasma Aβ levels including the novel Aβ peptide 1–38 (Aβ
Externí odkaz:
https://doaj.org/article/ecdb183ca60d436ab431349423ac2dde
Autor:
Davide Chiasserini, Leonardo Biscetti, Paolo Eusebi, Nicola Salvadori, Giulia Frattini, Simone Simoni, Naomi De Roeck, Nicola Tambasco, Erik Stoops, Hugo Vanderstichele, Sebastiaan Engelborghs, Brit Mollenhauer, Paolo Calabresi, Lucilla Parnetti
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2017)
Abstract Background Neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease with dementia (PDD), and dementia with Lewy bodies (DLB) share clinical and molecular features. Cerebrospinal fluid (CSF) biomarkers may help th
Externí odkaz:
https://doaj.org/article/4eeb7bb9cf3e433080bb4b06d204934f
Autor:
Hugo Vanderstichele, Leentje Demeyer, Shorena Janelidze, Els Coart, Erik Stoops, Kimberley Mauroo, Victor Herbst, Cindy François, Oskar Hansson
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-10 (2017)
Abstract Background The pathophysiology of neurodegeneration is complex. Its diagnosis requires an early identification of sequential changes in several hallmarks in the brains of affected subjects. The presence of brain pathology can be visualized i
Externí odkaz:
https://doaj.org/article/6986320673544da6ab630bc8529c3866
Autor:
Pratishtha Chatterjee, Michelle Tegg, Steve Pedrini, Anne M. Fagan, Chengjie Xiong, Abhay K. Singh, Kevin Taddei, Samantha Gardener, Colin L. Masters, Peter R. Schofield, Gerhard Multhaup, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Steven M. Greenberg, Mark A. van Buchem, Erik Stoops, Hugo Vanderstichele, Charlotte E. Teunissen, Graeme J. Hankey, Marieke J. H. Wermer, Hamid R. Sohrabi, Ralph N. Martins, the Dominantly Inherited Alzheimer Network
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2931 (2021)
Plasma amyloid-beta (Aβ) has long been investigated as a blood biomarker candidate for Cerebral Amyloid Angiopathy (CAA), however previous findings have been inconsistent which could be attributed to the use of less sensitive assays. This study inve
Externí odkaz:
https://doaj.org/article/139ce76d7c744e60835aa00e628f7219
Autor:
Sylvain Lehmann, Constance Delaby, Guilaine Boursier, Cindy Catteau, Nelly Ginestet, Laurent Tiers, Aleksandra Maceski, Sophie Navucet, Claire Paquet, Julien Dumurgier, Eugeen Vanmechelen, Hugo Vanderstichele, Audrey Gabelle
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Background: Cerebrospinal fluid (CSF) biomarkers (Aβ peptides and tau proteins) improved the diagnosis of Alzheimer’s disease (AD) in research and clinical settings. We previously described the PLM-scale (Paris-Lille-Montpellier study), which comb
Externí odkaz:
https://doaj.org/article/ad80b40a8fb742abb4f089e76dce60d7