Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hugo Temperley"'
Autor:
Maria Davern, Noel E. Donlon, Fiona O’ Connell, Andrew D. Sheppard, Conall Hayes, Ross King, Hugo Temperley, Christine Butler, Anshul Bhardwaj, Jenny Moore, Dara Bracken-Clarke, Claire Donohoe, Narayanasamy Ravi, John V. Reynolds, Stephen G. Maher, Melissa J. Conroy, Joanne Lysaght
Publikováno v:
Translational Oncology, Vol 20, Iss , Pp 101406- (2022)
Response rates to immune checkpoint blockade (ICB) remain low in oesophageal adenocarcinoma (OAC). Combining ICB with immunostimulatory chemotherapies to boost response rates is an attractive approach for converting ‘cold’ tumours into ‘hot’
Externí odkaz:
https://doaj.org/article/c52c824c793a4acdab0d58f23a41159d
Autor:
Noel E. Donlon, Maria Davern, Andrew D. Sheppard, Fiona O’Connell, Margaret R. Dunne, Conall Hayes, Eimear Mylod, Sinead Ramjit, Hugo Temperley, Michael Mac Lean, Gillian Cotter, Anshul Bhardwaj, Christine Butler, Melissa J. Conroy, Jacintha O’Sullivan, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundImmune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains unknown. Our study profiles systemic
Externí odkaz:
https://doaj.org/article/c1c43e80139b48f2bdb847aa34f8da63
Autor:
Maria Davern, Noel E. Donlon, Fiona O’Connell, Caoimhe Gaughan, Cillian O’Donovan, Mohammed Habash, Andrew D. Sheppard, Michael MacLean, Margaret R. Dunne, Jenny Moore, Hugo Temperley, Melissa J. Conroy, Christine Butler, Anshul Bhardwaj, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Publikováno v:
Cancer Immunology, Immunotherapy. 72:55-71
Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study investigated the effect of ac
Autor:
Maria, Davern, Noel E, Donlon, Fiona, O'Connell, Caoimhe, Gaughan, Cillian, O'Donovan, Jason, McGrath, Andrew D, Sheppard, Conall, Hayes, Ross, King, Hugo, Temperley, Michael, MacLean, Christine, Bulter, Anshul, Bhardwaj, Jenny, Moore, Claire, Donohoe, Narayanasamy, Ravi, Melissa J, Conroy, John V, Reynolds, Joanne, Lysaght
Publikováno v:
Journal of Cancer Research and Clinical Oncology.
Aim Use of immune checkpoint blockade to enhance T cell-mediated immunity within the hostile tumour microenvironment (TME) is an attractive approach in oesophageal adenocarcinoma (OAC). This study explored the effects of the hostile TME, including nu
Autor:
John V. Reynolds, Noel E. Donlon, Jessie A. Elliott, Brendan Moran, Hugo Temperley, Tim S. Nugent, Maria Davern, Sinead King, Melissa Conroy, Joanne Lysaght, Narayanasamy Ravi, Carmel Ryan, Stephen Finn, Suzanne Norris, Clare L. Donohoe
Publikováno v:
World journal of surgery. 47(1)
Esophageal adenocarcinoma (EAC) is associated with visceral obesity (VO). Non-alcoholic fatty liver disease (NAFLD) is common within this phenotype; however, its incidence and clinical significance in EAC have not been studied.A total of 559 patients
Autor:
Hugo Temperley, Cian Murray, James Carey, Jarlath Bolger, Narayanasamy Ravi, John V Reynolds, Claire Donohoe
Publikováno v:
British Journal of Surgery. 108
Background Vitamin B12 deficiency is a well described complication post gastrectomy. It is caused by the loss of parietal cell mass leading to megaloblastic anaemia and possible long term neurological symptoms. Treatment can be with standardised repl
Autor:
Hugo Temperley, Caitlin Waters, Kirsten Larkins, Cian Murray, Niall J. O'Sullivan, David Mockler, Gemma Humm, Catriona Norden, Eimear Phoenix, Claire L. Donohoe, Satish Warrier, Helen Mohan
Publikováno v:
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 48(5)
Multidisciplinary meetings are an important part of cancer care and surgical planning. However, there is also an important educational role of MDMs in training the next generation of surgical oncologists. This systematic review (SR) aimed to examine
Autor:
Conall Hayes, Hugo Temperley, Maria Davern, F O’Connell, Andrew Sheppard, J O’ Sullivan, Claire L. Donohoe, C Butler, Noel E Donlon, S Ramjit, Joanne Lysaght, N Ravi, M Mc Clean, John V. Reynolds, Dunne
Publikováno v:
Poster Presentations.
Background Immune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of oesophageal adenocarcinoma (OAC). The most appropriate time to incorporate ICIs remains unknown. Our study profiles syst
Autor:
Hugo Temperley, J Carey, John V. Reynolds, N Ravi, Noel E Donlon, Caitlin Waters, Claire L. Donohoe
Publikováno v:
British Journal of Surgery. 108
Background Chyle leak/fistula is a rare complication of oesophageal surgery, usually consequent on an unintended breach of the thoracic duct, its tributaries, or the cisterna chyli. For high volume persistent leaks further surgery has been the tradit
Autor:
Seamus Morris, Daniel P. Ahern, Jake M McDonnell, Hugo Temperley, Caitlin Waters, Gráinne M Cunniffe, Keith Synnott, Shane Evans, Laura McCarthy, Nick Birch, Joseph S. Butler
Publikováno v:
The bonejoint journal. (9)
In recent years, machine learning (ML) and artificial neural networks (ANNs), a particular subset of ML, have been adopted by various areas of healthcare. A number of diagnostic and prognostic algorithms have been designed and implemented across a ra