Impact of cyclometalated ruthenium(II) complexes on lactate dehydrogenase activity and cytotoxicity in gastric and colon cancer cells

Autor: Christian Gaiddon, Longzhu Q. Shen, Alexander D. Ryabov, Rafael Díaz, Christophe Orvain, Ronan Le Lagadec, Hugo Rico Bautista

Publikováno v: Journal of Inorganic Biochemistry
Journal of Inorganic Biochemistry, Elsevier, 2016, 163, pp.28-38. ⟨10.1016/j.jinorgbio.2016.07.014⟩
Journal of Inorganic Biochemistry, 2016, 163, pp.28-38. ⟨10.1016/j.jinorgbio.2016.07.014⟩

International audience; Lactate dehydrogenase (LDH) is a redox enzyme often overexpressed in cancer cells allowing their survival in stressful metabolic tumor environment. Ruthenium(II) complexes have been shown to impact on the activity of purified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d2e1f705d92d140f5611036b187768
https://www.hal.inserm.fr/inserm-02365314