Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Hugo R. de Jonge"'
Autor:
Dora Angyal, Tessa A. Groeneweg, Anny Leung, Max Desain, Kalyan Dulla, Hugo R. de Jonge, Marcel J. C. Bijvelds
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-20 (2024)
Abstract Background Loss of CFTR-dependent anion and fluid secretion in the ducts of the exocrine pancreas is thought to contribute to the development of pancreatitis, but little is known about the impact of inflammation on ductal CFTR function. Here
Externí odkaz:
https://doaj.org/article/2b6764ebb7ab4c6aaab158efdbccfd7c
Autor:
Shaojun Shi, Henk P. Roest, Thierry P.P. van den Bosch, Marcel J.C. Bijvelds, Markus U. Boehnert, Jeroen de Jonge, Sven O. Dekker, Antoine A.F. de Vries, Hugo R. de Jonge, Monique M.A. Verstegen, Luc J.W. van der Laan
Publikováno v:
EBioMedicine, Vol 88, Iss , Pp 104431- (2023)
Summary: Background: Ischemia of the bile duct is a common feature in liver disease and transplantation, which represents a major cause of morbidity and mortality, especially after liver transplantation. Detailed knowledge of its pathogenesis remains
Externí odkaz:
https://doaj.org/article/fccca7c2c5564e5b9c23a18e37e160f2
Autor:
Jennifer Kelly, Miran Al-Rammahi, Kristian Daly, Paul K. Flanagan, Arun Urs, Marta C. Cohen, Gabriella di Stefano, Marcel J. C. Bijvelds, David N. Sheppard, Hugo R. de Jonge, Ursula E. Seidler, Soraya P. Shirazi-Beechey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Defective CFTR leads to accumulation of dehydrated viscous mucus within the small intestine, luminal acidification and altere
Externí odkaz:
https://doaj.org/article/839c5ac368f2469ea3deaf9f54353d59
Autor:
Monique M. A. Verstegen, Floris J. M. Roos, Ksenia Burka, Helmuth Gehart, Myrthe Jager, Maaike de Wolf, Marcel J. C. Bijvelds, Hugo R. de Jonge, Arif I. Ardisasmita, Nick A. van Huizen, Henk P. Roest, Jeroen de Jonge, Michael Koch, Francesco Pampaloni, Sabine A. Fuchs, Imre F. Schene, Theo M. Luider, Hubert P. J. van der Doef, Frank A. J. A. Bodewes, Ruben H. J. de Kleine, Bart Spee, Gert-Jan Kremers, Hans Clevers, Jan N. M. IJzermans, Edwin Cuppen, Luc J. W. van der Laan
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract The development, homeostasis, and repair of intrahepatic and extrahepatic bile ducts are thought to involve distinct mechanisms including proliferation and maturation of cholangiocyte and progenitor cells. This study aimed to characterize hu
Externí odkaz:
https://doaj.org/article/eb9e7d98f7234f40b94f21db6d99f8db
Autor:
Pauline T. Ikpa, Marcela Doktorova, Kelly F. Meijsen, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Johan W. Jonker, Hugo R. de Jonge, Marcel J.C. Bijvelds
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 47-60 (2020)
Background & Aims: The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbios
Externí odkaz:
https://doaj.org/article/0a415309b75c4917861654a9a812df3d
Autor:
Christine Polte, Daniel Wedemeyer, Kathryn E. Oliver, Johannes Wagner, Marcel J. C. Bijvelds, John Mahoney, Hugo R. de Jonge, Eric J. Sorscher, Zoya Ignatova
Publikováno v:
BMC Genomics, Vol 20, Iss S8, Pp 1-12 (2019)
Abstract Background By definition, effect of synonymous single-nucleotide variants (SNVs) on protein folding and function are neutral, as they alter the codon and not the encoded amino acid. Recent examples indicate tissue-specific and transfer RNA (
Externí odkaz:
https://doaj.org/article/3cbbce1c6eb74632b9d6448a1ea289bd
Autor:
Jianyi Yin, Chung-Ming Tse, Leela Rani Avula, Varsha Singh, Jennifer Foulke-Abel, Hugo R. de Jonge, Mark Donowitz
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 591-609 (2018)
Background & Aims: Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the contributions of Cl- and HCO3- secretion to total cyclic adenosine monophosphate (cAMP)-st
Externí odkaz:
https://doaj.org/article/4f92a8c3a890408d92789264e3bdcf46
Autor:
Dora Angyal, Marcel J. C. Bijvelds, Marco J. Bruno, Maikel P. Peppelenbosch, Hugo R. de Jonge
Publikováno v:
Cells, Vol 11, Iss 1, p 54 (2021)
CFTR, the cystic fibrosis (CF) gene-encoded epithelial anion channel, has a prominent role in driving chloride, bicarbonate and fluid secretion in the ductal cells of the exocrine pancreas. Whereas severe mutations in CFTR cause fibrosis of the pancr
Externí odkaz:
https://doaj.org/article/401100de1853472ba3be0b360ac851f1
Autor:
Gitte Berkers, Peter van Mourik, Annelotte M. Vonk, Evelien Kruisselbrink, Johanna F. Dekkers, Karin M. de Winter-de Groot, Hubertus G.M. Arets, Rozemarijn E.P. Marck-van der Wilt, Jasper S. Dijkema, Maaike M. Vanderschuren, Roderick H.J. Houwen, Harry G.M. Heijerman, Eduard A. van de Graaf, Sjoerd G. Elias, Christof J. Majoor, Gerard H. Koppelman, Jolt Roukema, Marleen Bakker, Hettie M. Janssens, Renske van der Meer, Robert G.J. Vries, Hans C. Clevers, Hugo R. de Jonge, Jeffrey M. Beekman, Cornelis K. van der Ent
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1701-1708.e3 (2019)
Summary: In vitro drug tests using patient-derived stem cell cultures offer opportunities to individually select efficacious treatments. Here, we provide a study that demonstrates that in vitro drug responses in rectal organoids from individual patie
Externí odkaz:
https://doaj.org/article/dc8d3a11cbb948418c73a2e8f5b11051
Autor:
Thiago S. L. Araújo, Taiane M. de Oliveira, Nayara A. de Sousa, Luan K.M. Souza, Francisca B. M. Sousa, Ana P. de Oliveira, Lucas A. D. Nicolau, Alfredo A. V. da Silva, Alyne R. Araújo, Pedro J. C. Magalhães, Daniel F. P. Vasconcelos, Hugo R. de Jonge, Marcellus H. L. P. Souza, Durcilene A. Silva, Regina C. M. Paula, Jand Venes R. Medeiros
Publikováno v:
Pharmaceuticals, Vol 13, Iss 1, p 17 (2020)
Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil’s semi-arid area. In this study, a chemical analysis was performed to investigate the antid
Externí odkaz:
https://doaj.org/article/2446b39e7c06444792ae74f6376bd6d5