Advancing Key Gaps in the Knowledge of Plasmodium vivax Cryptic Infections Using Humanized Mouse Models and Organs-on-Chips

Autor: Iris Aparici Herraiz, Hugo R. Caires, Óscar Castillo-Fernández, Núria Sima, Lourdes Méndez-Mora, Ruth M. Risueño, Jetsumon Sattabongkot, Wanlapa Roobsoong, Aurora Hernández-Machado, Carmen Fernandez-Becerra, Cristina C. Barrias, Hernando A. del Portillo

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Plasmodium vivax is the most widely distributed human malaria parasite representing 36.3% of disease burden in the South-East Asia region and the most predominant species in the region of the Americas. Recent estimates indicate that 3.3 billion of pe

Externí odkaz: https://doaj.org/article/e135a84b9c1c4a46b90b94e27a1c9f0a

The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance

Autor: Cristina P. R. Xavier, Hugo R. Caires, Mélanie A. G. Barbosa, Rui Bergantim, José E. Guimarães, M. Helena Vasconcelos

Publikováno v: Cells, Vol 9, Iss 5, p 1141 (2020)

Extracellular vesicles (EVs) mediate intercellular signaling and communication, allowing the intercellular exchange of proteins, lipids, and genetic material. Their recognized role in the maintenance of the physiological balance and homeostasis seems

Externí odkaz: https://doaj.org/article/0a536c6db3164f7b906a7790974e696e

Detection of Measurable Residual Disease Biomarkers in Extracellular Vesicles from Liquid Biopsies of Multiple Myeloma Patients—A Proof of Concept

Autor: Rui Bergantim, Sara Peixoto da Silva, Bárbara Polónia, Mélanie A. G. Barbosa, André Albergaria, Jorge Lima, Hugo R. Caires, José E. Guimarães, M. Helena Vasconcelos

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13686

Monitoring measurable residual disease (MRD) is crucial to assess treatment response in Multiple Myeloma (MM). Detection of MRD in peripheral blood (PB) by exploring Extracellular Vesicles (EVs), and their cargo, would allow frequent and minimally in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7e61cde9f6cafb20fb0b36ee09d853
https://doi.org/10.3390/ijms232213686

miRNAs mediated drug resistance in hematological malignancies

Autor: Hugo R. Caires, Rui Bergantim, Jose E. Guimaraes, Sara Peixoto da Silva, M. Helena Vasconcelos

Publikováno v: Seminars in cancer biology. 83

Despite improvements in the therapeutic approaches for hematological malignancies in the last decades, refractory disease still occurs, and cancer drug resistance still remains a major hurdle in the clinical management of these cancer patients. The i

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https://pubmed.ncbi.nlm.nih.gov/33757848

Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesicles

Autor: Hugo R. Caires, Maria José Oliveira, Ricardo Ribeiro, M. Helena Vasconcelos, Avelino Fraga, Manuel Castanheira de Oliveira

Publikováno v: Cancers, Vol 12, Iss 1400, p 1400 (2020)
Cancers
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ec2adc2289fc7cbdd628d8d4e1534d
https://www.mdpi.com/2072-6694/12/6/1400