Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Hugo R de Jonge"'
Autor:
Dora Angyal, Tessa A. Groeneweg, Anny Leung, Max Desain, Kalyan Dulla, Hugo R. de Jonge, Marcel J. C. Bijvelds
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-20 (2024)
Abstract Background Loss of CFTR-dependent anion and fluid secretion in the ducts of the exocrine pancreas is thought to contribute to the development of pancreatitis, but little is known about the impact of inflammation on ductal CFTR function. Here
Externí odkaz:
https://doaj.org/article/2b6764ebb7ab4c6aaab158efdbccfd7c
Autor:
Frank A J A Bodewes, Marcel J Bijvelds, Willemien de Vries, Juul F W Baller, Annette S H Gouw, Hugo R de Jonge, Henkjan J Verkade
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117599 (2015)
The cause of Cystic fibrosis liver disease (CFLD), is unknown. It is well recognized that hepatic exposure to hydrophobic bile salts is associated with the development of liver disease. For this reason, we hypothesize that, CFTR dependent variations,
Externí odkaz:
https://doaj.org/article/230d9cf2ec4e4b89807b8a7e492bbaf4
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52070 (2012)
Most patients with Cystic Fibrosis (CF) carry at least one allele with the F508del mutation, resulting in a CFTR chloride channel protein with a processing, gating and stability defect, but with substantial residual activity when correctly sorted to
Externí odkaz:
https://doaj.org/article/e4a72a852bf842899d97d2b6bc5bfb9f
Autor:
Jennifer Kelly, Miran Al-Rammahi, Kristian Daly, Paul K. Flanagan, Arun Urs, Marta C. Cohen, Gabriella di Stefano, Marcel J. C. Bijvelds, David N. Sheppard, Hugo R. de Jonge, Ursula E. Seidler, Soraya P. Shirazi-Beechey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Defective CFTR leads to accumulation of dehydrated viscous mucus within the small intestine, luminal acidification and altere
Externí odkaz:
https://doaj.org/article/839c5ac368f2469ea3deaf9f54353d59
Autor:
Shaojun Shi, Henk P. Roest, Thierry P.P. van den Bosch, Marcel J.C. Bijvelds, Markus U. Boehnert, Jeroen de Jonge, Sven O. Dekker, Antoine A.F. de Vries, Hugo R. de Jonge, Monique M.A. Verstegen, Luc J.W. van der Laan
Publikováno v:
EBioMedicine, Vol 88, Iss , Pp 104431- (2023)
Summary: Background: Ischemia of the bile duct is a common feature in liver disease and transplantation, which represents a major cause of morbidity and mortality, especially after liver transplantation. Detailed knowledge of its pathogenesis remains
Externí odkaz:
https://doaj.org/article/fccca7c2c5564e5b9c23a18e37e160f2
Autor:
Monique M. A. Verstegen, Floris J. M. Roos, Ksenia Burka, Helmuth Gehart, Myrthe Jager, Maaike de Wolf, Marcel J. C. Bijvelds, Hugo R. de Jonge, Arif I. Ardisasmita, Nick A. van Huizen, Henk P. Roest, Jeroen de Jonge, Michael Koch, Francesco Pampaloni, Sabine A. Fuchs, Imre F. Schene, Theo M. Luider, Hubert P. J. van der Doef, Frank A. J. A. Bodewes, Ruben H. J. de Kleine, Bart Spee, Gert-Jan Kremers, Hans Clevers, Jan N. M. IJzermans, Edwin Cuppen, Luc J. W. van der Laan
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract The development, homeostasis, and repair of intrahepatic and extrahepatic bile ducts are thought to involve distinct mechanisms including proliferation and maturation of cholangiocyte and progenitor cells. This study aimed to characterize hu
Externí odkaz:
https://doaj.org/article/eb9e7d98f7234f40b94f21db6d99f8db
Autor:
Dora Angyal, Marcel J. C. Bijvelds, Marco J. Bruno, Maikel P. Peppelenbosch, Hugo R. de Jonge
Publikováno v:
Cells, Vol 11, Iss 1, p 54 (2021)
CFTR, the cystic fibrosis (CF) gene-encoded epithelial anion channel, has a prominent role in driving chloride, bicarbonate and fluid secretion in the ductal cells of the exocrine pancreas. Whereas severe mutations in CFTR cause fibrosis of the pancr
Externí odkaz:
https://doaj.org/article/401100de1853472ba3be0b360ac851f1
Autor:
Dora Angyal, Marcel J. C. Bijvelds, Marco J. Bruno, Maikel P. Peppelenbosch, Hugo R. de Jonge
Publikováno v:
Cells
Cells, Vol 11, Iss 54, p 54 (2022)
Cells, 11(1):54, 1-18. Multidisciplinary Digital Publishing Institute (MDPI)
Cells, Vol 11, Iss 54, p 54 (2022)
Cells, 11(1):54, 1-18. Multidisciplinary Digital Publishing Institute (MDPI)
CFTR, the cystic fibrosis (CF) gene-encoded epithelial anion channel, has a prominent role in driving chloride, bicarbonate and fluid secretion in the ductal cells of the exocrine pancreas. Whereas severe mutations in CFTR cause fibrosis of the pancr
Autor:
Marcel J C, Bijvelds, Floris J M, Roos, Kelly F, Meijsen, Henk P, Roest, Monique M A, Verstegen, Hettie M, Janssens, Luc J W, van der Laan, Hugo R, de Jonge
Publikováno v:
Journal of Cystic Fibrosis, 21(3), 537-543. Elsevier
Background: In cystic fibrosis (CF), loss of CF transmembrane conductance regulator (CFTR)-dependent bicarbonate secretion precipitates the accumulation of viscous mucus in the lumen of respiratory and gastrointestinal epithelial tissues. We investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0955b9e7749c092c1aa328854aa6984
https://pure.eur.nl/en/publications/4db722ee-f0b8-47d4-be18-49316f5ed366
https://pure.eur.nl/en/publications/4db722ee-f0b8-47d4-be18-49316f5ed366
Autor:
Hugo R. de Jonge, Kelly F. Meijsen, Johan W. Jonker, Pauline T. Ikpa, Marcel J. C. Bijvelds, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Marcela Doktorova
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 47-60 (2020)
Cellular and molecular gastroenterology and hepatology, 9(1), 47-60. HANLEY & BELFUS-ELSEVIER INC
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 9(1), 47-60. Elsevier Inc.
Cellular and molecular gastroenterology and hepatology, 9(1), 47-60. HANLEY & BELFUS-ELSEVIER INC
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 9(1), 47-60. Elsevier Inc.
Background & Aims The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbiosi