Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Hugo R Arias"'
Autor:
Hugo R. Arias, Laura Micheli, Deborah Rudin, Ophelie Bento, Saskia Borsdorf, Clara Ciampi, Philippe Marin, Evgeni Ponimaskin, Dina Manetti, Maria Novella Romanelli, Carla Ghelardini, Matthias E. Liechti, Lorenzo Di Cesare Mannelli
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116867- (2024)
The aim of this study was to determine the anti-hypersensitivity activity of novel non-hallucinogenic compounds derived from iboga alkaloids (i.e., ibogalogs), including tabernanthalog (TBG), ibogainalog (IBG), and ibogaminalog (DM506), using mouse m
Externí odkaz:
https://doaj.org/article/c642e18ca6d94d9db88979a07890f2b3
Autor:
Patricia Möller-Acuña, J Sebastián Contreras-Riquelme, Cecilia Rojas-Fuentes, Gabriel Nuñez-Vivanco, Jans Alzate-Morales, Patricio Iturriaga-Vásquez, Hugo R Arias, Miguel Reyes-Parada
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134444 (2015)
Evidence from systems biology indicates that promiscuous drugs, i.e. those that act simultaneously at various protein targets, are clinically better in terms of efficacy, than those that act in a more selective fashion. This has generated a new trend
Externí odkaz:
https://doaj.org/article/b6ff2c52ab2c48fc83667a7baf5fbae6
Autor:
Spencer R. Pierce, Allison L. Germann, Sophia Q. Xu, Saumith L. Menon, Marcelo O. Ortells, Hugo R. Arias, Gustav Akk
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 698 (2023)
The positive allosteric modulators (PAMs) of the α7 nicotinic receptor N-(5-Cl-2-hydroxyphenyl)-N′-[2-Cl-5-(trifluoromethyl)phenyl]-urea (NS-1738) and (E)-3-(furan-2-yl)-N-(p-tolyl)-acrylamide (PAM-2) potentiate the α1β2γ2L GABAA receptor throu
Externí odkaz:
https://doaj.org/article/7b45852e7ea54e64b1ae9c0efcc1c93d
Autor:
Dina Manetti, Silvia Dei, Hugo R. Arias, Laura Braconi, Alessio Gabellini, Elisabetta Teodori, Maria Novella Romanelli
Publikováno v:
Molecules, Vol 28, Iss 3, p 1270 (2023)
Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent agonists, allosteric activating PAMs and neutral or silent allosteric modulators are compounds capable of modulating the nicotinic receptor by interacting at alloste
Externí odkaz:
https://doaj.org/article/afa0960c813f46e7a046a8340201fde9
Autor:
Hugo R, Arias, Allison L, Germann, Spencer R, Pierce, Seiji, Sakamoto, Marcelo O, Ortells, Itaru, Hamachi, Gustav, Akk
Publikováno v:
British Journal of Pharmacology. 179:5323-5337
Positive allosteric modulators of the α7 nicotinic acetylcholine (nACh) receptor (α7-PAMs) possess promnesic and procognitive properties and have potential in the treatment of cognitive and psychiatric disorders including Alzheimer's disease and sc
Autor:
Jacob D. Layne, Mason J. Hochstetler, Brandon M. Curry, Benjamin M. Williams, Christina A. Small, Scott C. Steffensen, Hugo R. Arias, Craig T. Werner
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Publikováno v:
Molecules, Vol 26, Iss 8, p 2149 (2021)
It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake transporters, thus elevating synaptic 5-HT levels and, finally, ameliorates depression symptoms. New e
Externí odkaz:
https://doaj.org/article/58d44cf5ed0f46e0a76b6f38883f65cb
Autor:
Eda Koseli, Belle Buzzi, Edward Choi, Torin Honaker, Javier González-Maeso, Jason Youkin, Dina Manetti, Maria Novella Romanelli, Hugo R. Arias, M. Imad Damaj
Publikováno v:
The Journal of Pain. 24:6-7
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 158:106405
Autor:
Han-Shen Tae, Gulce Sevdar, Rabha Younis, Hugo R. Arias, Sinan Cavun, Deniz Bagdas, Mine Sibel Gurun, Zulfiye Gul, Marcelo O. Ortells
Publikováno v:
Neurological Research. 43:1056-1068
Clinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulat