Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Hugo Poulin"'
Autor:
Mohammed Djemai, Dominic Jauvin, Hugo Poulin, Charles-Albert Chapotte-Baldacci, Mohamed Chahine
Publikováno v:
Stem Cell Research, Vol 75, Iss , Pp 103308- (2024)
Dilated cardiomyopathy (DCM) is a prevalent cause of heart failure. We generated induced pluripotent stem cell (iPSC) lines from a DCM patient carrying a mutation in the SCN5A gene, with his healthy father serving as a control. Notably, we employed C
Externí odkaz:
https://doaj.org/article/d154aec2aaac4c9895800de07eb5f23e
Autor:
Quentin Plumereau, Aya Ebdalla, Hugo Poulin, Juan Pablo Appendino, Morris H. Scantlebury, Ping Yee Billie Au, Mohamed Chahine
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. SCN1A encodes NaV1.1, a neuronal voltage-gated Na+ channel that is highly expressed throughout the central nervous system. NaV1.1 is localized within
Externí odkaz:
https://doaj.org/article/afc4011b45dd422dae83232bed6bea5c
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Cardiomyocytes derived from patient-specific induced pluripotent stem cells (iPSC-CMs) successfully reproduce the mechanisms of several channelopathies. However, this approach involve cell reprogramming from somatic tissue biopsies or genomi
Externí odkaz:
https://doaj.org/article/4bf1dac3ef8f4d93b3a3c3419f760e38
Autor:
Hugo Poulin, Aurélie Mercier, Mohammed Djemai, Valérie Pouliot, Isabelle Deschenes, Mohamed Boutjdir, Jack Puymirat, Mohamed Chahine
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Cardiac complications such as electrical abnormalities including conduction delays and arrhythmias are the main cause of death in individuals with Myotonic Dystrophy type 1 (DM1). We developed a disease model using iPSC-derived cardiomyocyte
Externí odkaz:
https://doaj.org/article/42b8fdf897964013a27497c44ed24efc
Autor:
Mohamed Chahine, Hugo Poulin
Publikováno v:
The Journal of Physiology. 599:1651-1664
Key points A human NaV 1.6 construct was established to study the biophysical consequences of the R1617Q mutation on NaV 1.6 identified in patients with unclassified epileptic encephalopathy and severe intellectual disability. The R1617Q mutation dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c71d403e04c04b07b1a7fc4a43299497
https://doi.org/10.1113/jp280838
https://doi.org/10.1113/jp280838
Autor:
Isabelle Deschenes, Mohamed Chahine, Valérie Pouliot, Mohamed Boutjdir, Hugo Poulin, Mohammed Djemai, Aurélie Mercier, Jack Puymirat
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Cardiac complications such as electrical abnormalities including conduction delays and arrhythmias are the main cause of death in individuals with Myotonic Dystrophy type 1 (DM1). We developed a disease model using iPSC-derived cardiomyocytes (iPSC-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805953b7b28d6658296b3f5fa711f5ad
https://doaj.org/article/42b8fdf897964013a27497c44ed24efc
https://doaj.org/article/42b8fdf897964013a27497c44ed24efc
Autor:
Xiao-Ru Yang, Vamsi Krishna Murthy Ginjupalli, Olivier Theriault, Hugo Poulin, Juan Pablo Appendino, Ping Yee Billie Au, Mohamed Chahine
Publikováno v:
J Neurophysiol
SCN2A encodes a voltage-gated sodium channel (Na(V)1.2) expressed throughout the central nervous system in predominantly excitatory neurons. Pathogenic variants in SCN2A are associated with epilepsy and neurodevelopmental disorders. Genotype-phenotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e342cdc9fa6448b9d69ef9bae01f20f
https://europepmc.org/articles/PMC9109789/
https://europepmc.org/articles/PMC9109789/
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Cardiomyocytes derived from patient-specific induced pluripotent stem cells (iPSC-CMs) successfully reproduce the mechanisms of several channelopathies. However, this approach involve cell reprogramming from somatic tissue biopsies or genomic editing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e4d1ee70e00d9e3b9ddcf77223cb5f
https://doi.org/10.1038/s41598-021-96474-6
https://doi.org/10.1038/s41598-021-96474-6
Autor:
Xiao-Ru Yang, Hugo Poulin, Valérie Pouliot, Quentin Plumereau, Juan Pablo Appendino, Ping Yee Billie Au, Mohamed Chahine
Publikováno v:
Biophysical Journal. 121:96a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca91a35e6f20a79859416bdfe68c1c95
https://doi.org/10.1016/j.bpj.2021.11.2256
https://doi.org/10.1016/j.bpj.2021.11.2256
Autor:
Saïd Bendahhou, Pascal Gosselin-Badaroudine, Serena Giuliano, Savine Vicart, Mohamed Chahine, Hugo Poulin, Sophie Nicole, Damien Sternberg, Karima Habbout, Bertrand Fontaine
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8, pp.2041. ⟨10.1038/s41598-018-20468-0⟩
Scientific Reports, 2018, 8, pp.2041. ⟨10.1038/s41598-018-20468-0⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8, pp.2041. ⟨10.1038/s41598-018-20468-0⟩
Scientific Reports, 2018, 8, pp.2041. ⟨10.1038/s41598-018-20468-0⟩
Mutations in NaV1.4, the skeletal muscle voltage-gated Na+ channel, underlie several skeletal muscle channelopathies. We report here the functional characterization of two substitutions targeting the R1451 residue and resulting in 3 distinct clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef7279d6e17036666d272fb8a3e31a0
http://link.springer.com/article/10.1038/s41598-018-20468-0
http://link.springer.com/article/10.1038/s41598-018-20468-0