Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hugo Poirier"'
Autor:
Hugo Poirier
Publikováno v:
VertigO (2009)
Externí odkaz:
https://doaj.org/article/a2ff6a95e6ff4feb9e58f1904691ec52
Autor:
Hugo Poirier
Publikováno v:
VertigO (2000)
Externí odkaz:
https://doaj.org/article/43aa0c1af9a64321bd7b45aff16056ea
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
Autor:
Maria D. Ribadeneira, Jianmin Duan, Nathalie Rioux, Maria Arias Montecillo, Hugo Poirier, Federico Colombo
Publikováno v:
Xenobiotica. 43:915-919
1. Prediction of biliary excretion is a challenge due to the lack of in vitro assays. Our laboratory previously demonstrated a highly significant correlation between in vitro IC50 values against mrp2 using rat canalicular liver plasma membrane vesicl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d553bace08e518d9cca5fb31686b432
https://doi.org/10.3109/00498254.2013.769649
https://doi.org/10.3109/00498254.2013.769649
Autor:
Karine Laquerre, Francis F. Arhin, Sandra S. Ferreira, Ingrid Sarmiento, Ibtihal Fadhil, Dario Lehoux, Thomas R. Parr, Ting Kang, Kelly S.E. Tanaka, Evelyne Dietrich, Jing Liu, Hugo Poirier, Tom J. Houghton, Laurence Caron, Daniel Delorme, Adel Rafai Far, Valerie Ostiguy, Gregory Moeck, Frederic Viens
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:9217-9229
Osteomyelitis is a difficult to treat bacterial infection of the bone. Delivering antibacterial agents to the bone may overcome the difficulties in treating this illness by effectively concentrating the antibiotic at the site of infection and by limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee5732ff7e7aa2631e5de87190b666a
https://doi.org/10.1016/j.bmc.2008.09.010
https://doi.org/10.1016/j.bmc.2008.09.010
Autor:
Hugo Poirier, Michel Garneau, Nathalie Rioux, Maria D. Ribadeneira, Edith Bellavance, Mariève Dupuis, Jianmin Duan
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 68:346-348
Biliary excretion can modulate the pharmacokinetic profile of drug candidates, and may represent a liability for drug-drug interactions. This study proposes a strategy to reduce biliary clearance using the efflux ratio in Caco-2 cells in parallel to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d6bc10972902d8b5a538a3b93b9157
https://doi.org/10.1016/j.vascn.2013.03.003
https://doi.org/10.1016/j.vascn.2013.03.003
Autor:
Richard Friesen, Lynn Dufresne, Tom Y.-H. Wu, Denis Riendeau, Yves Ducharme, Joseph A. Mancini, Myriam Salem, Christine Brideau, Sébastien Guiral, Helene Juteau, Hugo Poirier
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(23)
Microsomal prostaglandin E 2 synthase (mPGES-1) represents a potential target for novel analgesic and anti-inflammatory agents. High-throughput screening identified several leads of mPGES-1 inhibitors which were further optimized for potency and sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de66c7f490f6be0a9ae9fb6b5c56b285
https://pubmed.ncbi.nlm.nih.gov/20965723
https://pubmed.ncbi.nlm.nih.gov/20965723
Autor:
Ingrid Sarmiento, Ibtihal Fadhil, Adel Rafai Far, Karine Laquerre, Sandra S. Ferreira, Yanick Lafontaine, Frederic Viens, Thomas R. Parr, Ting Kang, Valerie Ostiguy, Dario Lehoux, Kelly S.E. Tanaka, Tom J. Houghton, Daniel Delorme, Francis F. Arhin, Gregory Moeck, Jing Liu, Evelyne Dietrich, Hugo Poirier
Publikováno v:
Journal of medicinal chemistry. 51(21)
Osteomyelitis is an infection located in bone and a notoriously difficult disease to manage, requiring frequent and heavy doses of systemically administered antibiotics. Targeting antibiotics to the bone after systemic administration may provide both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c0adeafc4873411fed5a6fe8422606
https://pubmed.ncbi.nlm.nih.gov/18834106
https://pubmed.ncbi.nlm.nih.gov/18834106
Autor:
Adel Rafai Far, Evelyne Dietrich, Hugo Poirier, Stephane Ciblat, Daniel Delorme, Adam Belley, Dario Lehoux, Geoffrey A. McKay, Yannick Rose, Ranga Reddy
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(4)
The preparation and biological evaluation of 5-substituted-6-hydroxy-2-(anilino)pyrimidinones as a new class of DNA polymerase IIIC inhibitors, required for the replication of chromosomal DNA in Gram-positive bacteria, are described. These new dGTP c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee27b40496e4e15015fddf390a277c16
https://pubmed.ncbi.nlm.nih.gov/16298129
https://pubmed.ncbi.nlm.nih.gov/16298129