Highly exposed segment of the Spf1p P5A-ATPase near transmembrane M5 detected by limited proteolysis.

Autor: Guido D Petrovich, Gerardo R Corradi, Carlos H Pavan, Sofia Noli Truant, Hugo P Adamo

Publikováno v: PLoS ONE, Vol 16, Iss 1, p e0245679 (2021)

The yeast Spf1p protein is a primary transporter that belongs to group 5 of the large family of P-ATPases. Loss of Spf1p function produces ER stress with alterations of metal ion and sterol homeostasis and protein folding, glycosylation and membrane

Externí odkaz: https://doaj.org/article/c410c647f7434783846693cff0a20dde

The effect of metal ions on the Spf1p P5A-ATPase. High sensitivity to irreversible inhibition by zinc

Autor: Guido D. Petrovich, Gerardo R. Corradi, Hugo P. Adamo

Publikováno v: Archives of biochemistry and biophysics. 732

The Spf1p protein from Saccharomyces cerevisiae belongs to the family of P5A-ATPases that have recently been shown to protect the endoplasmic reticulum by dislocating misinserted membrane proteins. The loss of function of P5A-ATPases leads to endopla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b5ef49e6cb325f074efdde228a490d
https://pubmed.ncbi.nlm.nih.gov/36328152

Reduction of the P5A-ATPase Spf1p phosphoenzyme by a Ca2+-dependent phosphatase

Autor: Paula Grenon, Michael G. Palmgren, Luciana R. Mazzitelli, Felicitas de Tezanos Pinto, Guido Daniel Petrovich, Hugo P. Adamo, Danny Mollerup Sørensen, Gerardo Raul Corradi

Publikováno v: PLoS ONE, Vol 15, Iss 4, p e0232476 (2020)
Corradi, G R, Mazzitelli, L R, Petrovich, G D, Grenon, P, Sørensen, D M, Palmgren, M, De Tezanos Pinto, F & Adamo, H P 2020, ' Reduction of the P5A-ATPase Spf1p phosphoenzyme by a Ca 2+-dependent phosphatase ', PLoS ONE, vol. 15, no. 4, e0232476 . https://doi.org/10.1371/journal.pone.0232476
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PLoS ONE

P5 ATPases are eukaryotic pumps important for cellular metal ion, lipid and protein homeostasis; however, their transported substrate, if any, remains to be identified. Ca2+ was proposed to act as a ligand of P5 ATPases because it decreases the level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ab6c20c05020c8bc71c29144b6cc50
https://doaj.org/article/95a419b303114c848932e20e134ba58a

The strategic function of the P5-ATPase ATP13A2 in toxic waste disposal

Autor: Felicitas de Tezanos Pinto, Hugo P. Adamo

Publikováno v: Neurochemistry international. 112

The P-type ATPase ATP13A2 protein was originally associated with a form of Parkinson´s Disease (PD)known as Kufor Rakeb Syndrome (KRS). However, in the last years it has been found to underlay variantsof neuronal ceroid-lipofuscinoses and hereditary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c531744fd9fff67cca4ed75da12f03d2
https://pubmed.ncbi.nlm.nih.gov/29169913

Shadows of an Absent Partner

Autor: Gerardo Raul Corradi, Luciana R. Mazzitelli, Felicitas de Tezanos Pinto, Hugo P. Adamo

Publikováno v: Journal of Biological Chemistry. 287:30477-30484

The P5-ATPases are important components of eukaryotic cells. They have been shown to influence protein biogenesis, folding, and transport. The knowledge of their biochemical properties is, however, limited, and the transported ions are still unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f260caa7a9816958b9dc78bd0683358
https://doi.org/10.1074/jbc.m112.363465