Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Hugo Oppelaar"'
Autor:
Asami Oguro-Ando, Rosemary A. Bamford, Wiedjai Sital, Jan J. Sprengers, Amila Zuko, Jolien M. Matser, Hugo Oppelaar, Angela Sarabdjitsingh, Marian Joëls, J. Peter. H. Burbach, Martien J. Kas
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neurodevelopmental and neuropsychiatric disorders, such as autism spectrum disorders (ASD), anorexia nervosa (AN), Alzheimer’s disease (AD), and schizophrenia (SZ), are heterogeneous brain disorders with unknown etiology. Genome wide studi
Externí odkaz:
https://doaj.org/article/53f044de4fd74bb99a68f5ff4e2e7313
Autor:
Eneda Pjetri, Ria de Haas, Simone de Jong, Cigdem Gelegen, Hugo Oppelaar, Linda A W Verhagen, Marinus J C Eijkemans, Roger A Adan, Berend Olivier, Martien J Kas
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50453 (2012)
Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric disorder phenotypes. Early indicators are critical for preventive and efficient treatment of progr
Externí odkaz:
https://doaj.org/article/fc7b1e65ba72473bb7f66435da962330
Autor:
Simone de Jong, Martien J H Kas, Jeffrey Kiernan, Annetrude G de Mooij-van Malsen, Hugo Oppelaar, Esther Janson, Igor Vukobradovic, Charles R Farber, William L Stanford, Roel A Ophoff
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20716 (2011)
In this study, we show that the covariance between behavior and gene expression in the brain can help further unravel the determinants of neurobehavioral traits. Previously, a QTL for novelty induced motor activity levels was identified on murine chr
Externí odkaz:
https://doaj.org/article/bef945617f9a4f0cb28eeeacb080d89c
Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression
Autor:
Danya Muilwijk, Eyleen de Poel, Peter van Mourik, Sylvia W.F. Suen, Annelotte M. Vonk, Jesse E. Brunsveld, Evelien Kruisselbrink, Hugo Oppelaar, Marne C. Hagemeijer, Gitte Berkers, Karin M. de Winter-de Groot, Sabine Heida-Michel, Stephan R. Jans, Hannah van Panhuis, Menno M. van der Eerden, Renske van der Meer, Jolt Roukema, Edward Dompeling, Els J.M. Weersink, Gerard H. Koppelman, Robert Vries, Domenique D. Zomer-van Ommen, Marinus J.C. Eijkemans, Cornelis K. van der Ent, Jeffrey M. Beekman
Publikováno v:
European Respiratory Journal, 60
European Respiratory Journal, 60, 2
European Respiratory Journal, 60(2):2100508. European Respiratory Society
European respiratory journal, 60(2):2100508. European Respiratory Society
Muilwijk, D, de Poel, E, van Mourik, P, Suen, S W F, Vonk, A M, Brunsveld, J E, Kruisselbrink, E, Oppelaar, H, Hagemeijer, M C, Berkers, G, de Winter-de Groot, K M, Heida-Michel, S, Jans, S R, van Panhuis, H, van der Eerden, M M, van der Meer, R, Roukema, J, Dompeling, E, Weersink, E J M, Koppelman, G H, Vries, R, Zomer-van Ommen, D D, Eijkemans, M J C, van der Ent, C K & Beekman, J M 2022, ' Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression ', European Respiratory Journal, vol. 60, no. 2, 2100508 . https://doi.org/10.1183/13993003.00508-2021
European Respiratory Journal, 60, 2
European Respiratory Journal, 60(2):2100508. European Respiratory Society
European respiratory journal, 60(2):2100508. European Respiratory Society
Muilwijk, D, de Poel, E, van Mourik, P, Suen, S W F, Vonk, A M, Brunsveld, J E, Kruisselbrink, E, Oppelaar, H, Hagemeijer, M C, Berkers, G, de Winter-de Groot, K M, Heida-Michel, S, Jans, S R, van Panhuis, H, van der Eerden, M M, van der Meer, R, Roukema, J, Dompeling, E, Weersink, E J M, Koppelman, G H, Vries, R, Zomer-van Ommen, D D, Eijkemans, M J C, van der Ent, C K & Beekman, J M 2022, ' Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression ', European Respiratory Journal, vol. 60, no. 2, 2100508 . https://doi.org/10.1183/13993003.00508-2021
RationaleCystic fibrosis (CF) is a monogenic life-shortening disease associated with highly variable individual disease progression which is difficult to predict. Here we assessed the association of forskolin-induced swelling (FIS) of patient-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf9da16f7bb9568249c8cf57a8787cc
https://pubmed.ncbi.nlm.nih.gov/35086832
https://pubmed.ncbi.nlm.nih.gov/35086832
Publikováno v:
British Journal of Cancer
Clinical photodynamic therapy (PDT) schedules are based on the assumption that optimum drug-light intervals are times at which there is a maximum differential between photosensitiser retention in the tumour and surrounding normal tissue. However, vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2a08a764afbcc285635c83caadc160
https://doi.org/10.1038/sj.bjc.6600682
https://doi.org/10.1038/sj.bjc.6600682
Autor:
Joost R.M. van der Sijp, Hugo Oppelaar, Fiona A. Stewart, Sjaak Burgers, Hugo Schouwink, Frans A. N. Zoetmulder, Nico van Zandwijk, Robert van Veen, Paul Baas, Emiel J. Th. Rutgers
Publikováno v:
Chest. 120:1167-1174
Objective To determine the optimal administered dose of meta-tetrahydroxyphenylchlorin (mTHPC) for intraoperative photodynamic therapy (IPDT) in resected malignant pleural mesothelioma (MPM). The primary objective of this combination treatment was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a15b406721b53e62db043c7978d0064
https://doi.org/10.1378/chest.120.4.1167
https://doi.org/10.1378/chest.120.4.1167
Autor:
Ruth B. Veenhuizen, Adrian Timmers, Hugo Oppelaar, Fiona A. Stewart, I. Bing Tan, Marjan Ruevekamp
Publikováno v:
Head & Neck. 21:434-441
Background Photodynamic therapy (PDT) is being evaluated for treatment of localized head and neck cancer. “Light dose” is usually prescribed as incident fluence, which takes no account of reflected and scattered light. This study investigates var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c36bd298b1d34de88bceb27aaf0f9e6a
https://doi.org/10.1002/(sici)1097-0347(199908)21:5<434::aid-hed9>3.0.co
https://doi.org/10.1002/(sici)1097-0347(199908)21:5<434::aid-hed9>3.0.co
Autor:
Ruth B. Veenhuizen, Theo J.M. Helmerhorst, Marjan Ruevekamp, Fiona A. Stewart, Peter Kenemans, Hugo Oppelaar
Publikováno v:
International Journal of Cancer. 73:230-235
Distribution of the photosensitizer Foscant (meta-tetrahydroxyphenylchlorin, mTHPC), after i.v. or i.p. injection, was investigated in Wag/Rij rats bearing i.p. tumours. These results were compared with the efficacy of mTHPC-mediated photodynamic the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc7b84093a9653e862f04457f348daa
https://doi.org/10.1002/(sici)1097-0215(19971009)73:2<230::aid-ijc12>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19971009)73:2<230::aid-ijc12>3.0.co
Autor:
Jan H.M. Schellens, Ruth B. Veenhuizen, Fiona A. Stewart, Otilia Dalesio, Marjan Ruevekamp, Hugo Oppelaar
Publikováno v:
International Journal of Cancer. 73:236-239
Preferential retention of photosensitizers in tumours has always been one of the major goals in the search for new photosensitizers and has determined the design of clinical trials with respect to the interval between drug administration and illumina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f136f1d534c4b2bc20a45c6e6fc2850a
https://doi.org/10.1002/(sici)1097-0215(19971009)73:2<236::aid-ijc13>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19971009)73:2<236::aid-ijc13>3.0.co
Publikováno v:
British Journal of Cancer
Selective delivery of cytotoxic anti-neoplastic drugs can diminish the severe side-effects associated with these drugs. Many malignant tumours express high levels of low-density lipoprotein (LDL) receptors on their membranes. Therefore, LDL may be us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d7cf51c2af5f8a8329208200b38bc2
http://europepmc.org/articles/PMC2074664
http://europepmc.org/articles/PMC2074664