Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hugo McGurran"'
Publikováno v:
Cells, Vol 13, Iss 5, p 407 (2024)
Toll-like receptors (TLRs) are a collection of pattern recognition sensors that form a first line of defence by detecting pathogen- or damage-associated molecular patterns and initiating an inflammatory response. TLR activation in microglia, the majo
Externí odkaz:
https://doaj.org/article/2dcbe1135ee74be0ac30de315b14de64
Autor:
Yu-Ting Hu, Xin-Lu Chen, Ya-Nan Zhang, Hugo McGurran, Jochem Stormmesand, Nicole Breeuwsma, Arja Sluiter, Juan Zhao, Dick Swaab, Ai-Min Bao
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionEpidemiological studies show that women have a higher prevalence of Alzheimer’s disease (AD) than men. Peripheral estrogen reduction during aging in women is proposed to play a key role in this sex-associated prevalence, however, the un
Externí odkaz:
https://doaj.org/article/d4c9a41be3b94cd6b80930d95039b8d4
Autor:
Joe C. Udeochu, Sadaf Amin, Yige Huang, Li Fan, Eileen Ruth S. Torres, Gillian K. Carling, Bangyan Liu, Hugo McGurran, Guillermo Coronas-Samano, Grant Kauwe, Gergey Alzaem Mousa, Man Ying Wong, Pearly Ye, Ravi Kumar Nagiri, Iris Lo, Julia Holtzman, Carlo Corona, Allan Yarahmady, Michael T. Gill, Ravikiran M. Raju, Sue-Ann Mok, Shiaoching Gong, Wenjie Luo, Mingrui Zhao, Tara E. Tracy, Rajiv R. Ratan, Li-Huei Tsai, Subhash C. Sinha, Li Gan
Publikováno v:
Nature Neuroscience. 26:737-750
Pathological hallmarks of Alzheimer’s disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of dementia. Here, we report that activation of cyclic GMP–AMP synthase (cGAS) diminishes cognitiv
Publikováno v:
Brain Structure & Function, 227, 2231-2242. Springer Verlag GmbH
The neuropathological substrates of Parkinson’s disease (PD) patients with motor subtypes tremor-dominance (TD), non-tremor dominance (nTD), postural instability and gait difficulty (PIGD), and akinetic-rigid (AR) are not completely differentiated.
Autor:
Hugo McGurran, Jackson Boonstra, Ai-Min Bao, Dick F. Swaab, Rawien Balesar, Arja A. Sluiter, Jochem Stormmesand, Yu-Ting Hu, Ronald W.H. Verwer
Publikováno v:
Neuropathology and Applied Neurobiology, 47, 958-966. Wiley-Blackwell
AIMS Women are more vulnerable to Alzheimer's disease (AD) than men. We investigated (i) whether and at what age the AD hallmarks, that is, β-amyloid (Aβ) and hyperphosphorylated Tau (p-Tau) show sex differences; and (ii) whether such sex differenc
Publikováno v:
Journal of Alzheimer's Disease. 69:311-338
Alzheimer's disease (AD) is the most common form of dementia. With an aging population and no disease modifying treatments available, AD is quickly becoming a global pandemic. A substantial body of research indicates that lifestyle behaviors contribu
Autor:
Hugo McGurran, Jackson Boonstra, Ai-Min Bao, Jochem Stormmesand, Dick F. Swaab, Arja A. Sluiter, Yu-Ting Hu, Ronald W.H. Verwer, Rawien Balesar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::489d1703d9bc28f5b354ab8aaaa46a0d
https://doi.org/10.1111/nan.12729/v4/response1
https://doi.org/10.1111/nan.12729/v4/response1
Publikováno v:
Current Alzheimer research. 17(5)
Alzheimer’s Disease (AD) incidence is increasing and with no disease modifying agents available, preventative measures through lifestyle factors are being investigated. Combined with the prevention of AD risk factors such as heart disease, diabetes
Autor:
Yu-Ting Hu, Xin-Lu Chen, Dick F. Swaab, Ai-Min Bao, Shu-Han Huang, Hugo McGurran, Jackson Boonstra
Publikováno v:
IBRO Reports. 6:S490-S491