Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hugo McGuire"'
Autor:
Hugo McGuire, Rikard Blunck
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Oligomerization and complex formation play a key role for many membrane proteins and has been described to influence ion channel function in both neurons and the heart. In this study, we observed clustering of single KcsA channels in planar lipid bil
Externí odkaz:
https://doaj.org/article/c75dbc41d2b64fb0afb88d0415fca412
Publikováno v:
The Journal of General Physiology
Polyamine block of AMPA-type ionotropic glutamate receptors is attenuated by auxiliary proteins stargazin and cornichon-3. Brown et al. show that relief from block is due to enhanced blocker permeation and present a modified model of permeant channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a017d2f39bed35a553eaf22121c5c90b
http://europepmc.org/articles/PMC5749116
http://europepmc.org/articles/PMC5749116
Autor:
Rikard Blunck, Filip Liebsch, Gerd Multhaup, Silvia Scolari, Tobias Bethge, Hugo McGuire, Derek Bowie, Mark R. P. Aurousseau, Andreas Herrmann
Publikováno v:
Journal of Biological Chemistry. 292:13258-13270
The β-secretase (BACE1) initiates processing of the amyloid precursor protein (APP) into Aβ peptides, which have been implicated as central players in the pathology of Alzheimer disease. BACE1 has been described as a copper-binding protein and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e2dbb3a70c9321dc90a77c81ff8bdf
https://doi.org/10.1074/jbc.m117.779165
https://doi.org/10.1074/jbc.m117.779165
Publikováno v:
Ionotropic Glutamate Receptor Technologies ISBN: 9781493928118
Determining the composition and stoichiometry of membrane-bound proteins has been a perennial problem that has plagued biology for a long time. The most recurring issue is that composition and subunit stoichiometry is commonly inferred from bulk bioc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e6348cb042be65139320f2d7a35282
https://doi.org/10.1007/978-1-4939-2812-5_2
https://doi.org/10.1007/978-1-4939-2812-5_2
Publikováno v:
J Biol Chem
Voltage-gated ion channels are responsible for the generation of action potentials in our nervous system. Conformational rearrangements in their voltage sensor domains in response to changes of the membrane potential control pore opening and thus ion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a229d7d70cbb656df39ca2f262502ce0
Publikováno v:
Journal of Biological Chemistry. 286:42274-42282
Pore-forming toxins constitute a class of potent virulence factors that attack their host membrane in a two- or three-step mechanism. After binding to the membrane, often aided by specific receptors, they form pores in the membrane. Pore formation ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b8c9d7d0bf45bbbe9b9d1cfab00b01
https://doi.org/10.1074/jbc.m111.296103
https://doi.org/10.1074/jbc.m111.296103
Autor:
Hugo McGuire, Rikard Blunck
Publikováno v:
médecine/sciences. 25:951-954
Les canaux potassiques prennent part a un grand nombre de processus physiologiques de l’organisme humain et constituent ainsi une cible importante pour les medicaments. Une bonne connaissance de la structure et des mecanismes moleculaires de ces pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e9ad463860192d80b2c55f7d85ac8a8
https://doi.org/10.1051/medsci/20092511951
https://doi.org/10.1051/medsci/20092511951
Autor:
Hugo McGuire, Rikard Blunck
Publikováno v:
Biophysical Journal. 108(2)
Protein oligomerization lies at the core of numerous biological processes, from cellular signal transduction to muscle contraction and cellular metabolism. It also notably drives the function of ion channels, as several subunits are often required to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ae48e11a3e164f42cf9c9f9c3547a6
Autor:
Daniel G. Bichet, Abdulah El Tarazi, Rikard Blunck, Yoann Lussier, Hugo McGuire, Pierre Bissonnette
Publikováno v:
The FASEB Journal. 28
Mutations in Aquaporin-2 (AQP2) induce nephrogenic diabetes insipidus, a water reabsorption defect of the kidney. Using co-immunoprecipitation and functional assays, we have recently shown that (at...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80b5c425e2376c02cc01fe3bfbe436d7
https://doi.org/10.1096/fasebj.28.1_supplement.1133.1
https://doi.org/10.1096/fasebj.28.1_supplement.1133.1
Elucidating subunit stoichiometry of neurotransmitter receptors is preferably carried out in a mammalian expression system where the rules of native protein assembly are strictly obeyed. Although successful in Xenopus oocytes, single subunit counting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b29c6815e585c31f7842ac88aac55b
https://europepmc.org/articles/PMC3476259/
https://europepmc.org/articles/PMC3476259/