Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Hugo Maas"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 1, Pp 27-40 (2023)
Abstract As formal causal inference begins to play a greater role in disciplines that intersect with pharmacometrics, such as biostatistics, epidemiology, and artificial intelligence/machine learning, pharmacometricians may increasingly benefit from
Externí odkaz:
https://doaj.org/article/fe41dfaea6214e6a9b82d35eb65d040b
Publikováno v:
CPT: pharmacometricssystems pharmacologyREFERENCES.
As formal causal inference begins to play a greater role in disciplines that intersect with pharmacometrics, such as biostatistics, epidemiology, and artificial intelligence/machine learning, pharmacometricians may increasingly benefit from a basic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff36d3360aa28f2937c10eeb1d08f981
https://pubmed.ncbi.nlm.nih.gov/36385744
https://pubmed.ncbi.nlm.nih.gov/36385744
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Models were developed to characterize the relationship between afatinib exposure and diarrhea and rash/acne adverse event (AE) trajectories, and their predictive ability was assessed. Based on pooled data from seven phase II/III clinical studies incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a016b07cc0b5263799f1f6b1f47a3e5f
https://doi.org/10.1002/psp4.12384
https://doi.org/10.1002/psp4.12384
Autor:
Igor Tartakovsky, Martina Brueckmann, Lesley G. Mitchell, Fenglei Huang, Hugo Maas, Joachim Stangier, Savion Gropper, Jacqueline Halton
Publikováno v:
Thrombosis and Haemostasis
Background Physiological age-related changes in the haemostatic and coagulation systems result in differing anticoagulant assay responses to standard anticoagulants. Therefore, we investigated the response of anticoagulant assays to dabigatran etexil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27e96bc21fabfd6d20bb01ab186fc46
https://doi.org/10.1055/s-0038-1668132
https://doi.org/10.1055/s-0038-1668132
Autor:
Lisa Bomgaars, Lesley G. Mitchell, Igor Tartakovsky, Matteo Luciani, Savion Gropper, Jacqueline Halton, Ruth Harper, Manuela Albisetti, Hugo Maas, Fenglei Huang, Branislav Biss, Martina Brueckmann
Publikováno v:
Journal of Thrombosis and Haemostasis. 15:2147-2157
Essentials Dabigatran etexilate may provide a new treatment option for pediatric venous thromboembolism. Children aged 1 to < 12 years were given dabigatran etexilate in an open-label, single-arm study. The pharmacokinetic–pharmacodynamic relations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a837356d055ff9a3b51fe6f5164dea68
https://doi.org/10.1111/jth.13847
https://doi.org/10.1111/jth.13847
Autor:
Lesley G. Mitchell, Manuela Albisetti, Savion Gropper, Jacqueline Halton, Elizabeth Chalmers, Martina Brueckmann, Ildar Nurmeev, Anne-Caroline Picard, Igor Tartakovsky, Leonardo R. Brandão, Fenglei Huang, Hugo Maas, Ruth Harper
Publikováno v:
Thrombosis and Haemostasis. 117:2168-2175
Venous thromboembolism (VTE) is more frequent in infants than in older children. Treatment guidelines in children are adapted from adult VTE data, but do not currently include direct oral anticoagulant use. Dabigatran etexilate (DE) use in the paedia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97ace21ef4d032a53b6060635674af5
https://doi.org/10.1160/th17-06-0429
https://doi.org/10.1160/th17-06-0429
Publikováno v:
Journal of Clinical Oncology. 20:4713-4721
PURPOSE: To develop a semimechanistic pharmacokinetic-pharmacodynamic model describing chemotherapy-induced myelosuppression through drug-specific parameters and system-related parameters, which are common to all drugs. PATIENTS AND METHODS: Patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c92c8f0b3cc6a29d0cf54b70af79b2f
https://doi.org/10.1200/jco.2002.02.140
https://doi.org/10.1200/jco.2002.02.140
Autor:
John W, Eikelboom, Stuart J, Connolly, Martina, Brueckmann, Christopher B, Granger, Arie P, Kappetein, Michael J, Mack, Jon, Blatchford, Kevin, Devenny, Jeffrey, Friedman, Kelly, Guiver, Ruth, Harper, Yasser, Khder, Maximilian T, Lobmeyer, Hugo, Maas, Jens-Uwe, Voigt, Maarten L, Simoons, Frans, Van de Werf, J, Rogowski
Publikováno v:
New England Journal of Medicine, 369(13), 1206-1214. Massachussetts Medical Society
New England journal of medicine, 369(13), 1206-1214. Massachussetts Medical Society
New England journal of medicine, 369(13), 1206-1214. Massachussetts Medical Society
BackgroundDabigatran is an oral direct thrombin inhibitor that has been shown to be an effective alternative to warfarin in patients with atrial fibrillation. We evaluated the use of dabigatran in patients with mechanical heart valves. MethodsIn this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4d96d1188472d4b299f2fb1f5268a2
https://pure.eur.nl/en/publications/1274a6e4-557a-4f4a-8a19-5e00d49fbd23
https://pure.eur.nl/en/publications/1274a6e4-557a-4f4a-8a19-5e00d49fbd23
Autor:
Matteo Luciani, Hugo Maas, Lesley G. Mitchell, Igor Tartakovsky, Fenglei Huang, Manuela Albisetti, Branislav Biss, Martina Brueckmann, Savion Gropper, Jacqueline Halton
Publikováno v:
Blood. 128:87-87
Background: The incidence of venous thromboembolism (VTE) in children is increasing. The current standard of care is unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and Vitamin K antagonists (VKAs), all of which have limitations. Da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccc0908969dcd7f17ff0f926e105928a
https://doi.org/10.1182/blood.v128.22.87.87
https://doi.org/10.1182/blood.v128.22.87.87
Autor:
Leonardo R. Brandão, Manuela Albisetti, Lesley G. Mitchell, Hugo Maas, Igor Tartakovsky, Anne-Caroline Picard, Fenglei Huang, Ruth Harper, Martina Brueckmann, Ildar Nurmeev, Savion Gropper, Jacqueline Halton
Publikováno v:
Blood. 128:1441-1441
Background: Venous thromboembolism (VTE) events are more frequent in neonates than in children of other age groups. The standard of care for pediatric anticoagulation includes unfractionated or low-molecular-weight heparin, or vitamin K antagonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f7e2279c1374435c54517e143be097
https://doi.org/10.1182/blood.v128.22.1441.1441
https://doi.org/10.1182/blood.v128.22.1441.1441