Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Hugo M. Botelho"'
Autor:
Mariana Coelho, Ana Patrícia Duarte, Sofia Pinto, Hugo M. Botelho, Catarina Pinto Reis, Maria Luísa Serralheiro, Rita Pacheco
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 684 (2023)
Seaweeds are popular foods due to claimed beneficial health effects, but for many there is a lack of scientific evidence. In this study, extracts of the edible seaweeds Aramé, Nori, and Fucus are compared. Our approach intends to clarify similaritie
Externí odkaz:
https://doaj.org/article/9c5d324415a640bbadcc28be2e1b5f0f
Autor:
Joana Godinho-Pereira, Margarida Dionísio Lopes, Ana Rita Garcia, Hugo M. Botelho, Rui Malhó, Inês Figueira, Maria Alexandra Brito
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1988 (2022)
Among breast cancer (BC) patients, 15–25% develop BC brain metastases (BCBM), a severe condition due to the limited therapeutic options, which points to the need for preventive strategies. We aimed to find a drug able to boost blood–brain barrier
Externí odkaz:
https://doaj.org/article/015f476410014390bcf69801d19f9aea
Publikováno v:
Cells, Vol 11, Iss 15, p 2295 (2022)
The plasma membrane (PM) stability of the cystic fibrosis transmembrane conductance regulator (CFTR), the protein which when mutated causes Cystic Fibrosis (CF), relies on multiple interaction partners that connect CFTR to signaling pathways, includi
Externí odkaz:
https://doaj.org/article/1ba5edbd397b4732b1260e86b675cfb3
Autor:
Célia Fernandes, Elisa Palma, Francisco Silva, Ana Belchior, Catarina I. G. Pinto, Joana F. Guerreiro, Hugo M. Botelho, Filipa Mendes, Paula Raposinho, António Paulo
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7238 (2022)
Although 99mTc is not an ideal Auger electron (AE) emitter for Targeted Radionuclide Therapy (TRT) due to its relatively low Auger electron yield, it can be considered a readily available “model” radionuclide useful to validate the design of new
Externí odkaz:
https://doaj.org/article/aa7fbeed660f4a59a2a048a27598af64
Autor:
Inna Uliyakina, Hugo M. Botelho, Ana C. da Paula, Sara Afonso, Miguel J. Lobo, Verónica Felício, Carlos M. Farinha, Margarida D. Amaral
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4524 (2020)
Cystic Fibrosis (CF) is caused by mutations in the CF Transmembrane conductance Regulator (CFTR), the only ATP-binding cassette (ABC) transporter functioning as a channel. Unique to CFTR is a regulatory domain which includes a highly conformationally
Externí odkaz:
https://doaj.org/article/7989cd197b8f4885a70b6b04fddf33c2
Autor:
João D. Santos, Sara Canato, Ana S. Carvalho, Hugo M. Botelho, Kerman Aloria, Margarida D. Amaral, Rune Matthiesen, Andre O. Falcao, Carlos M. Farinha
Publikováno v:
Cells, Vol 8, Iss 4, p 353 (2019)
The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention and early degradation. It is
Externí odkaz:
https://doaj.org/article/8c742a672b6c4bb389c4e071889ff2bf
Autor:
Bebiana Sá-Moura, Ana Marisa Simões, Joana Fraga, Humberto Fernandes, Isabel A. Abreu, Hugo M. Botelho, Cláudio M. Gomes, António J. Marques, R. Jürgen Dohmen, Paula C. Ramos, Sandra Macedo-Ribeiro
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 7, Iss 8 (2013)
Protein degradation is essential for maintaining cellular homeostasis. The proteasome is the centralenzyme responsible for non-lysosomal protein degradation in eukaryotic cells. Although proteasome assembly is not yet completelyunderstood, a number o
Externí odkaz:
https://doaj.org/article/0ef0dca3b6c44117b9015a89ce3415b8
Autor:
Marne C. Hagemeijer, Nikhil T. Awatade, Christian Tischer, Annelotte M. Vonk, Margarida D. Amaral, Jeffrey M. Beekman, Volker Hilsenstein, Iris A.L. Silva, Hugo M. Botelho
Publikováno v:
Bioinformatics. 36:5686-5694
MotivationThe forskolin-induced swelling (FIS) assay has become the preferential assay to predict the efficacy of approved and investigational CFTR-modulating drugs for individuals with cystic fibrosis (CF). Currently, no standardized quantification
Autor:
Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride and bicarbonate channel in secretory epithelia with a critical role in maintaining fluid homeostasis. Mutations in CFTR are associated with Cystic Fibrosis (CF), the most common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abec01881446dc64e4a0ec5c4fcb78af
https://hdl.handle.net/10281/413713
https://hdl.handle.net/10281/413713
Autor:
Margarida C Quaresma, Hugo M Botelho, Ines Pankonien, Cláudia S Rodrigues, Madalena C Pinto, Pau R Costa, Aires Duarte, Margarida D Amaral
Publikováno v:
Life science alliance. 5(9)
Mutations in the CFTR anion channel cause cystic fibrosis (CF) and have also been related to higher cancer incidence. Previously we proposed that this is linked to an emerging role of functional CFTR in protecting against epithelial–mesenchymal tra