Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Hugo M Botelho"'
Autor:
Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 2, Pp n/a-n/a (2022)
Abstract Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride and bicarbonate channel in secretory epithelia with a critical role in maintaining fluid homeostasis. Mutations in CFTR are associated with Cystic Fibrosis (CF), the mo
Externí odkaz:
https://doaj.org/article/2333634eb31448bfa35a483208141fd8
Autor:
Sofia B Carvalho, Hugo M Botelho, Sónia S Leal, Isabel Cardoso, Günter Fritz, Cláudio M Gomes
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76629 (2013)
S100 proteins are small dimeric calcium-binding proteins which control cell cycle, growth and differentiation via interactions with different target proteins. Intrinsic disorder is a hallmark among many signaling proteins and S100 proteins have been
Externí odkaz:
https://doaj.org/article/e4ef1df11a5f4840ae448d955468eb1f
Autor:
Mariana Coelho, Ana Patrícia Duarte, Sofia Pinto, Hugo M. Botelho, Catarina Pinto Reis, Maria Luísa Serralheiro, Rita Pacheco
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 684 (2023)
Seaweeds are popular foods due to claimed beneficial health effects, but for many there is a lack of scientific evidence. In this study, extracts of the edible seaweeds Aramé, Nori, and Fucus are compared. Our approach intends to clarify similaritie
Externí odkaz:
https://doaj.org/article/9c5d324415a640bbadcc28be2e1b5f0f
Autor:
Joana Godinho-Pereira, Margarida Dionísio Lopes, Ana Rita Garcia, Hugo M. Botelho, Rui Malhó, Inês Figueira, Maria Alexandra Brito
Publikováno v:
Biomedicines; Volume 10; Issue 8; Pages: 1988
Among breast cancer (BC) patients, 15–25% develop BC brain metastases (BCBM), a severe condition due to the limited therapeutic options, which points to the need for preventive strategies. We aimed to find a drug able to boost blood–brain barrier
Autor:
Célia Fernandes, Elisa Palma, Francisco Silva, Ana Belchior, Catarina I. G. Pinto, Joana F. Guerreiro, Hugo M. Botelho, Filipa Mendes, Paula Raposinho, António Paulo
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7238
Although 99mTc is not an ideal Auger electron (AE) emitter for Targeted Radionuclide Therapy (TRT) due to its relatively low Auger electron yield, it can be considered a readily available “model” radionuclide useful to validate the design of new
Publikováno v:
Cells; Volume 11; Issue 15; Pages: 2295
The plasma membrane (PM) stability of the cystic fibrosis transmembrane conductance regulator (CFTR), the protein which when mutated causes Cystic Fibrosis (CF), relies on multiple interaction partners that connect CFTR to signaling pathways, includi
Autor:
Marne C. Hagemeijer, Nikhil T. Awatade, Christian Tischer, Annelotte M. Vonk, Margarida D. Amaral, Jeffrey M. Beekman, Volker Hilsenstein, Iris A.L. Silva, Hugo M. Botelho
Publikováno v:
Bioinformatics. 36:5686-5694
MotivationThe forskolin-induced swelling (FIS) assay has become the preferential assay to predict the efficacy of approved and investigational CFTR-modulating drugs for individuals with cystic fibrosis (CF). Currently, no standardized quantification
Autor:
Margarida C Quaresma, Hugo M Botelho, Ines Pankonien, Cláudia S Rodrigues, Madalena C Pinto, Pau R Costa, Aires Duarte, Margarida D Amaral
Publikováno v:
Life science alliance. 5(9)
Mutations in the CFTR anion channel cause cystic fibrosis (CF) and have also been related to higher cancer incidence. Previously we proposed that this is linked to an emerging role of functional CFTR in protecting against epithelial–mesenchymal tra
Autor:
Madalena C. Pinto, Hugo M. Botelho, Iris A.L. Silva, Violeta Railean, Beate Neumann, Rainer Pepperkok, Rainer Schreiber, Karl Kunzelmann, Margarida D. Amaral
Publikováno v:
Journal of molecular biology. 434(5)
An attractive approach to treat people with Cystic Fibrosis (CF), a life-shortening disease caused by mutant CFTR, is to compensate for the absence of this chloride/bicarbonate channel by activating alternative (non-CFTR) chloride channels. One obvio
Autor:
A. Belchior, Sofia Gama, Isabel Correia, Inês Rodrigues, Hugo M. Botelho, Maria Fátima Araújo, Elisa Palma, António Paulo, Goreti Ribeiro Morais, Maria Paula Cabral Campello, Susana Sousa Gomes, Nádia Ribeiro, Filipa Mendes, Paula D. Raposinho, Isabel Santos
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 24:71-89
The development of pharmacologically active compounds based on bis(thiosemicarbazones) (BTSC) and on their coordination to metal centers constitutes a promising field of research. We have recently explored this class of ligands and their Cu(II) compl