Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Hugo Lee"'
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102923- (2024)
Summary: A subpopulation of pancreatic beta cells becomes senescent during type 1 diabetes (T1D) progression, and removal of these populations protects against T1D in mice. Here, we present a protocol to measure senescence in murine pancreatic islet
Externí odkaz:
https://doaj.org/article/bcf47eb9f10e430dafad249751dcd9f7
Publikováno v:
Frontiers in Earth Science, Vol 11 (2023)
In regions of the world where topography varies significantly with distance, most global climate models (GCMs) have spatial resolutions that are too coarse to accurately simulate key meteorological variables that are influenced by topography, such as
Externí odkaz:
https://doaj.org/article/0c13b11769f04f8ea9181e3704e1b38d
Autor:
Chien-Wen Chen, Bo-Jhih Guan, Mohammed R. Alzahrani, Zhaofeng Gao, Long Gao, Syrena Bracey, Jing Wu, Cheikh A. Mbow, Raul Jobava, Leena Haataja, Ajay H. Zalavadia, Ashleigh E. Schaffer, Hugo Lee, Thomas LaFramboise, Ilya Bederman, Peter Arvan, Clayton E. Mathews, Ivan C. Gerling, Klaus H. Kaestner, Boaz Tirosh, Feyza Engin, Maria Hatzoglou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Pancreatic β-cells are naturally prone to ER stress due to their role in insulin production and secretion. Here, the authors show that chronic ER stress adaptive exhaustion results in an irreversible loss of β-cell function leading to T1D pathogene
Externí odkaz:
https://doaj.org/article/adc88863189241eabee325b0cf1b9532
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Chronic elevation of sphingolipids contributes to β-cell failure. ORMDL3 has been identified as a key regulator of sphingolipid homeostasis, however, its function in pancreatic β-cell pathophysiology remains unclear. Here, we generated a mouse mode
Externí odkaz:
https://doaj.org/article/8bd436ddf37f4752a6ee2d63e167b2d6
Autor:
Wilson K. M. Wong, Vinod Thorat, Mugdha V. Joglekar, Charlotte X. Dong, Hugo Lee, Yi Vee Chew, Adwait Bhave, Wayne J. Hawthorne, Feyza Engin, Aniruddha Pant, Louise T. Dalgaard, Sharda Bapat, Anandwardhan A. Hardikar
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Machine learning (ML)-workflows enable unprejudiced/robust evaluation of complex datasets. Here, we analyzed over 490,000,000 data points to compare 10 different ML-workflows in a large (N=11,652) training dataset of human pancreatic single-cell (sc-
Externí odkaz:
https://doaj.org/article/4c6b7c34dcfa4335982bc4796e302990
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101365- (2021)
Background: Pancreatic β-cells are the insulin factory of an organism with a mission to regulate glucose homeostasis in the body. Due to their high secretory activity, β-cells rely on a functional and intact endoplasmic reticulum (ER). Perturbation
Externí odkaz:
https://doaj.org/article/cffe1661c7714398ae1a70141d83d43b
Autor:
Hugo Lee, Feyza Engin
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100144- (2020)
Summary: Pancreatic islets consist of several cell types, including alpha, beta, delta, epsilon, and PP cells. Due to cellular heterogeneity, it is challenging to interpret whole-islet transcriptome data. Single-cell transcriptomics offers a powerful
Externí odkaz:
https://doaj.org/article/cb491f656205401b811b23a8f8311330
Autor:
Hugo Lee, Rachel J. Fenske, Tugce Akcan, Elliot Domask, Dawn B. Davis, Michelle E. Kimple, Feyza Engin
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101324- (2020)
Summary: The orosomucoid-like (Ormdl) proteins play a critical role in sphingolipid homeostasis, inflammation, and ER stress, all of which are associated with obesity and βcell dysfunction. However, their roles in β cells and obesity remain unknown
Externí odkaz:
https://doaj.org/article/e4129b60719e479c8bf64f74152ff202
Publikováno v:
Journal of Pediatric Ophthalmology & Strabismus. 59:350-355
Purpose: To compare the surgical outcomes of unilateral lateral rectus recession to bilateral lateral rectus recession for small angle intermittent exotropia. Methods: This was a retrospective cohort study of pediatric patients with an intermittent e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebbdb9c90523045088eccf8956b9b8c
https://doi.org/10.3928/01913913-20220131-03
https://doi.org/10.3928/01913913-20220131-03
Autor:
Chiaw-Ling Chng, Kaiping Zheng, Ann Kerwen Kwee, Ming-Han Hugo Lee, Ting, Daniel, Chen Pong Wong, Guoyu Hu, Beng Chin Ooi, Si Wei Kheok
Publikováno v:
Frontiers in Endocrinology; 2024, p1-12, 12p