Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hugo Lachance"'
Autor:
Carl-Hugo Lachance, Michel Baillargeon
Publikováno v:
Canadian Journal of Diabetes. 42:226-228
Autor:
Miroslava Strmiskova, Yingche Chen, Kelvin Tsao, Christopher M. Clouthier, Jeffrey W. Keillor, Hugo Lachance
Publikováno v:
Angewandte Chemie. 126:14005-14008
A fluorescent protein-labeling strategy was developed in which a protein of interest (POI) is genetically tagged with a short peptide sequence presenting two Cys residues that can selectively react with synthetic fluorogenic reagents. These fluorogen
Autor:
Sabrina Bergmann, Beate Schölermann, Claas Gerding-Reimers, Tobias Voigt, Petra Janning, Slava Ziegler, Herbert Waldmann, Hugo Lachance, Andreas Brockmeyer, Tuyen Thi Ngoc Tran
Publikováno v:
Angewandte Chemie International Edition. 52:410-414
A Prins cyclization between a polymer-bound aldehyde and a homoallylic alcohol served as the key step in the synthesis of tetrahydropyran derivatives. A phenotypic screen led to the identification of compounds that inhibit mitosis (as seen by the acc
Publikováno v:
Journal of Medicinal Chemistry
Natural products are a heterogeneous group of compounds with diverse, yet particular molecular properties compared to synthetic compounds and drugs. All relevant analyses show that natural products indeed occupy parts of chemical space not explored b
Publikováno v:
Tetrahedron Letters. 49:6061-6064
A synthetic approach to the polysubstituted pyran core and amide side chain of psymberin (irciniastatin A) using stereoselective organoboron methodology is described. An advanced oxyranyl pyran intermediate was prepared using a catalytic enantioselec
Autor:
Carl-Hugo Lachance
Publikováno v:
Canadian journal of diabetes. 40(5)
A diagnosis of diabetes will naturally impact an individual’s life. Unfortunately, the type of diabetes is rarely confirmed, and patients and their physicians rarely question the classification. Some data show that 7% to 15% of patients are incorre
Publikováno v:
Tetrahedron Letters. 46:8981-8985
The stereo- and chemoselectivity in the additions of four model α-substituted allylboronates to benzaldehyde was examined under the standard thermal (uncatalyzed) conditions and the novel Lewis and Bronsted acid-catalyzed conditions. With either of
Publikováno v:
The Journal of Organic Chemistry. 70:4180-4183
[reaction: see text] Chiral diols are important molecules with widespread use as chiral auxiliaries and ligands in enantioselective synthesis. Therefore, efficient and practical syntheses of highly dissymmetrical nonracemic diols are still a meaningf
Autor:
Frédéric Ausseil, Jean-Marc Gregoire, Alexandre Gagnon, Anzhelika Kabro, Yves St-Pierre, Vicky Doré, Moshe Szyf, Véronique Masson, Hugo Lachance, Paola B. Arimondo, Christina Gros, Nathalie Bibens Laulan, Iris Marcoux-Archambault, David Cheishvili, Valérie Perrier
Publikováno v:
MedChemComm
MedChemComm, Royal Society of Chemistry, 2013, 4 (12), pp.1562-1570. ⟨10.1039/C3MD00214D⟩
MedChemComm, Royal Society of Chemistry, 2013, 4 (12), pp.1562-1570. ⟨10.1039/C3MD00214D⟩
International audience; DNA-methyltransferases (DNMTs) are a class of epigenetic enzymes that catalyze the transfer of a methyl moiety from the methyl donor S-adenosyl-L-methionine onto the C5 position of cytosine in DNA. This process is dysregulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e73f6de2f2e44fe9527afdc3fd287fa
https://hal-riip.archives-ouvertes.fr/pasteur-01133260
https://hal-riip.archives-ouvertes.fr/pasteur-01133260
Publikováno v:
Tetrahedron Letters. 46:4547-4549
Substituted 3-(triisopropylsilyl)-2-naphthols are prepared by an aluminum chloride catalyzed condensation of phenyl acetyl chloride derivatives and triisopropylsilyl acetylene. The yields obtained are in the range of 41% to 67%. The reaction is regio