Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hugo J.G. Snippert"'
Autor:
Sander Mertens, Maarten A. Huismans, Carla S. Verissimo, Bas Ponsioen, Rene Overmeer, Natalie Proost, Olaf van Tellingen, Marieke van de Ven, Harry Begthel, Sylvia F. Boj, Hans Clevers, Jeanine M.L. Roodhart, Johannes L. Bos, Hugo J.G. Snippert
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112324- (2023)
Summary: Patient-derived organoids (PDOs) are widely heralded as a drug-screening platform to develop new anti-cancer therapies. Here, we use a drug-repurposing library to screen PDOs of colorectal cancer (CRC) to identify hidden vulnerabilities with
Externí odkaz:
https://doaj.org/article/90d447bcda174d4aba2b71aaf83d4fbd
Autor:
Jia-Yun Chen, Clemens Hug, José Reyes, Chengzhe Tian, Luca Gerosa, Fabian Fröhlich, Bas Ponsioen, Hugo J.G. Snippert, Sabrina L. Spencer, Ashwini Jambhekar, Peter K. Sorger, Galit Lahav
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112252- (2023)
Summary: Oncogene-induced senescence is a phenomenon in which aberrant oncogene expression causes non-transformed cells to enter a non-proliferative state. Cells undergoing oncogenic induction display phenotypic heterogeneity, with some cells senesci
Externí odkaz:
https://doaj.org/article/36dd9f1bb081478bb61988811e5931cb
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100126- (2020)
Summary: Patient-derived organoids maintain functional and phenotypic characteristics of the original tissue such as cell-type diversity. Here, we provide protocols on how to label intestinal (cancer) stem cells by integrating the stem cell ASCL2 rep
Externí odkaz:
https://doaj.org/article/7cfad3f580b34877a7de744413024fcc
Autor:
Koen C. Oost, Lisa van Voorthuijsen, Arianna Fumagalli, Rik G.H. Lindeboom, Joep Sprangers, Manja Omerzu, Maria J. Rodriguez-Colman, Maria C. Heinz, Ingrid Verlaan-Klink, Madelon M. Maurice, Boudewijn M.T. Burgering, Jacco van Rheenen, Michiel Vermeulen, Hugo J.G. Snippert
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1600-1614 (2018)
Summary: Organoid technology provides the possibility of culturing patient-derived colon tissue and colorectal cancers (CRCs) while maintaining all functional and phenotypic characteristics. Labeling stem cells, especially in normal and benign tumor
Externí odkaz:
https://doaj.org/article/9ca3720b339f42e798b532a67bfc4e49
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Table 3. Z-scores of significantly differential expressed genes (provided separately due to size)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd7a5cdaea3cae2756f7f3ba9a1d2b0
https://doi.org/10.1158/1541-7786.22516890
https://doi.org/10.1158/1541-7786.22516890
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Table 2. Differential Gene Expression Analysis on BRAF (fusion) gene expressing organoid lines (provided separately due to size)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83b7cfca6f3763b19eeb21621703961
https://doi.org/10.1158/1541-7786.22516893
https://doi.org/10.1158/1541-7786.22516893
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Fusion genes can be oncogenic drivers in a variety of cancer types and represent potential targets for targeted therapy. The BRAF gene is frequently involved in oncogenic gene fusions, with fusion frequencies of 0.2%–3% throughout different cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8629dd530804e56c9fe1b264e5794128
https://doi.org/10.1158/1541-7786.c.6541530
https://doi.org/10.1158/1541-7786.c.6541530
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4aaa5fed854746109257e41a9a600b
https://doi.org/10.1158/1541-7786.22516905
https://doi.org/10.1158/1541-7786.22516905
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Table 1. KSEA kinase scores and kinase-substrate links identified in phosphoproteomic screen (provided separately due to size)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7756805d064facf4c02a067cf0b356c9
https://doi.org/10.1158/1541-7786.22516896
https://doi.org/10.1158/1541-7786.22516896
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Table 4. List of BRAF (fusion) gene and GFP-specific primers. Primer used for breakpoint PCR, HA-tag spanning PCR and for the gateway cloning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9142eb90faef125f8320a8a0450b28ad
https://doi.org/10.1158/1541-7786.22516887.v1
https://doi.org/10.1158/1541-7786.22516887.v1