Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Hugo J. Snippert"'
Autor:
Rik GH Lindeboom, Lisa van Voorthuijsen, Koen C Oost, Maria J Rodríguez‐Colman, Maria V Luna‐Velez, Cristina Furlan, Floriane Baraille, Pascal WTC Jansen, Agnès Ribeiro, Boudewijn MT Burgering, Hugo J Snippert, Michiel Vermeulen
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 6, Pp 1-16 (2018)
Abstract Intestinal organoids accurately recapitulate epithelial homeostasis in vivo, thereby representing a powerful in vitro system to investigate lineage specification and cellular differentiation. Here, we applied a multi‐omics framework on ste
Externí odkaz:
https://doaj.org/article/8a98095e739748a999d0a70f9fe23845
Autor:
Maria Azkanaz, Bernat Corominas-Murtra, Saskia I. J. Ellenbroek, Lotte Bruens, Anna T. Webb, Dimitrios Laskaris, Koen C. Oost, Simona J. A. Lafirenze, Karl Annusver, Hendrik A. Messal, Sharif Iqbal, Dustin J. Flanagan, David J. Huels, Felipe Rojas-Rodríguez, Miguel Vizoso, Maria Kasper, Owen J. Sansom, Hugo J. Snippert, Prisca Liberali, Benjamin D. Simons, Pekka Katajisto, Edouard Hannezo, Jacco van Rheenen
Publikováno v:
Nature, 607(7919), 548-554. Nature Publishing Group
Nature
Nature
The morphology and functionality of the epithelial lining differ along the intestinal tract, but tissue renewal at all sites is driven by stem cells at the base of crypts(1-3). Whether stem cell numbers and behaviour vary at different sites is unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056f78ddf82a288546d7d0c38e5f8447
http://www.scopus.com/inward/record.url?scp=85134162879&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85134162879&partnerID=8YFLogxK
Autor:
Sippe G. de Vries, Wigard P. Kloosterman, Holger Rehmann, William Cross, Myrna van den Bos, Sander Boymans, Bingxin Lu, Susanne M.A. Lens, Hugo J. Snippert, Yannik Bollen, Markus J. van Roosmalen, Maximilian Mossner, Nicolle Besselink, Ellen Stelloo, Christopher Kimberley, Edwin Cuppen, Chris P. Barnes, Petra van Leenen, Bas Ponsioen, Ana C. F. Bolhaqueiro, Koen C. Oost, Bastiaan van der Roest, Trevor A. Graham, Andrea Sottoriva, Geert J. P. L. Kops, Leon W.M.M. Terstappen
Publikováno v:
Nature Genetics, 53(8), 1187-1195. Nature Publishing Group
Nature Genetics
Nature genetics, 53(8), 1187-1195. Nature Publishing Group
Nature Genetics
Nature genetics, 53(8), 1187-1195. Nature Publishing Group
Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at single-cell resolution. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651f73d2429a0f3686a912f64c06f306
https://doi.org/10.1038/s41588-021-00891-2
https://doi.org/10.1038/s41588-021-00891-2
Autor:
Sanne Hindriksen, Arne J Bramer, My Anh Truong, Martijn J M Vromans, Jasmin B Post, Ingrid Verlaan-Klink, Hugo J Snippert, Susanne M A Lens, Michael A Hadders
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179514 (2017)
The CRISPR/Cas9 system is a highly effective tool for genome editing. Key to robust genome editing is the efficient delivery of the CRISPR/Cas9 machinery. Viral delivery systems are efficient vehicles for the transduction of foreign genes but commonl
Externí odkaz:
https://doaj.org/article/7494e7114e524a7d9b4feecd32edebc9
Autor:
Carla S Verissimo, René M Overmeer, Bas Ponsioen, Jarno Drost, Sander Mertens, Ingrid Verlaan-Klink, Bastiaan van Gerwen, Marieke van der Ven, Marc van de Wetering, David A Egan, René Bernards, Hans Clevers, Johannes L Bos, Hugo J Snippert
Publikováno v:
eLife, Vol 5 (2016)
Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel of CRC organoids carrying either wild-type or mutant RAS, as well as normal organoids and
Externí odkaz:
https://doaj.org/article/7501d8e3fc1b4a42aa7676d2bb0a2f09
Autor:
Markus J. van Roosmalen, Jasmin B. Post, Wigard P. Kloosterman, Marco J. Koudijs, Emile E. Voest, Hugo J. Snippert, Christina Stangl, Nizar Hami, Harmjan R. Vos, Robert M. van Es, Ingrid Verlaan-Klink
Publikováno v:
Molecular Cancer Research. 18:537-548
Fusion genes can be oncogenic drivers in a variety of cancer types and represent potential targets for targeted therapy. The BRAF gene is frequently involved in oncogenic gene fusions, with fusion frequencies of 0.2%–3% throughout different cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28e3ed1819360fabf4c4cff2c1543793
https://doi.org/10.1158/1541-7786.mcr-19-0529
https://doi.org/10.1158/1541-7786.mcr-19-0529
Autor:
Huili Hu, Ellen J. Wehrens, Koen C. Oost, Anne C. Rios, Annelotte M. Vonk, Jane E. Visvader, Hans Clevers, Johanna F. Dekkers, Paul R. Jamieson, Hendrikus C R Ariese, Maria Alieva, Jeffrey M. Beekman, Hugo J. Snippert, Gimano D. Amatngalim, Lianne M Wellens
Publikováno v:
Nature Protocols, 14(6), 1756-1771. Nature Publishing Group
In vitro 3D organoid systems have revolutionized the modeling of organ development and diseases in a dish. Fluorescence microscopy has contributed to the characterization of the cellular composition of organoids and demonstrated organoids' phenotypic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e167f6e747cde0439071404446ac4798
https://doi.org/10.1038/s41596-019-0160-8
https://doi.org/10.1038/s41596-019-0160-8
Autor:
Toshimi Yoshida, Hugo J. Snippert, Brejnev M. Muhire, Christine J. Williams, Katia Georgopoulos, Zhihong Zhang, Akinola Olumide Emmanuel, Fotini Gounari, Yeguang Hu, Michael Y. Tolstorukov, Kiriaki Galani
Publikováno v:
Genes & Development. 33:763-781
Coordinated induction, but also repression, of genes are key to normal differentiation. Although the role of lineage-specific transcription regulators has been studied extensively, their functional integration with chromatin remodelers, one of the ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e67829520b3bf3c5c9a0fc6380cfed
https://doi.org/10.1101/gad.321901.118
https://doi.org/10.1101/gad.321901.118
Autor:
Ana C.F. Bolhaqueiro, Nizar Hami, Devanjali Dutta, Nobuo Sasaki, Onno Kranenburg, Judith Vivié, Marc van de Wetering, Peter M. Lansdorp, Robert G.J. Vries, Alexander van Oudenaarden, Geert J. P. L. Kops, Hans Clevers, Diana C.J. Spierings, Hugo J. Snippert, Ingrid Verlaan-Klink, Bas Ponsioen, Emre Kucukkose, Richard H. van Jaarsveld, Bjorn Bakker, Sjoerd J Klaasen, Floris Foijer, Sylvia F. Boj
Publikováno v:
Nature Genetics, 51(5), 824-834. Nature Publishing Group
Nature Genetics, 51(5), 824. Nature Publishing Group
Nature Genetics
Nature Genetics, 51(5), 824. Nature Publishing Group
Nature Genetics
Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are hallmarks of cancer in humans. A persistent high frequency of these errors (chromosomal instability (CIN)) is predicted to profoundly impact tumor evolution and thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b637145e8645875a97251b5e1efac78f
https://hdl.handle.net/11370/da433299-4d50-49bb-a271-e0c7cc029bf5
https://hdl.handle.net/11370/da433299-4d50-49bb-a271-e0c7cc029bf5
Autor:
Suraya Elfrink, Hugo J. Snippert, Nizar Hami, Johannes L. Bos, Jasmin B. Post, Alexander E E Mertens
Publikováno v:
Oncotarget, 10, 1440-1457
Oncotarget, 10, 14, pp. 1440-1457
Oncotarget
Oncotarget, 10, 14, pp. 1440-1457
Oncotarget
Contains fulltext : 215760.pdf (Publisher’s version ) (Open Access) Anti-EGFR therapy is used to treat metastatic colorectal cancer (CRC) patients, for which initial response rates of 10-20% have been achieved. Although the presence of HER2 amplifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6992417bbaae60e72ea6c7a9d4e131
https://doi.org/10.18632/oncotarget.26677
https://doi.org/10.18632/oncotarget.26677