Zobrazeno 1 - 10
of 420
pro vyhledávání: '"Hugo J Bellen"'
Autor:
Xueyang Pan, Albert N Alvarez, Mengqi Ma, Shenzhao Lu, Michael W Crawford, Lauren C Briere, Oguz Kanca, Shinya Yamamoto, David A Sweetser, Jenny L Wilson, Ruth J Napier, Jonathan N Pruneda, Hugo J Bellen
Publikováno v:
eLife, Vol 12 (2023)
Protein UFMylation downstream of the E1 enzyme UBA5 plays essential roles in development and endoplasmic reticulum stress. Variants in the UBA5 gene are associated with developmental and epileptic encephalopathy 44 (DEE44), an autosomal recessive dis
Externí odkaz:
https://doaj.org/article/628d985a60454271b521505c531678b8
Autor:
Guang Lin, Burak Tepe, Geoff McGrane, Regine C Tipon, Gist Croft, Leena Panwala, Amanda Hope, Agnes JH Liang, Zhongyuan Zuo, Seul Kee Byeon, Lily Wang, Akhilesh Pandey, Hugo J Bellen
Publikováno v:
eLife, Vol 12 (2023)
Infantile neuroaxonal dystrophy (INAD) is caused by recessive variants in PLA2G6 and is a lethal pediatric neurodegenerative disorder. Loss of the Drosophila homolog of PLA2G6, leads to ceramide accumulation, lysosome expansion, and mitochondrial def
Externí odkaz:
https://doaj.org/article/e4633d77eb604aa29a4117eee3456289
Autor:
Justin A Bosch, Berrak Ugur, Israel Pichardo-Casas, Jordan Rabasco, Felipe Escobedo, Zhongyuan Zuo, Ben Brown, Susan Celniker, David A Sinclair, Hugo J Bellen, Norbert Perrimon
Publikováno v:
eLife, Vol 11 (2022)
Naturally produced peptides (
Externí odkaz:
https://doaj.org/article/6549c99e7d9d4f4292fd9b2eb3a57f4b
Autor:
Oguz Kanca, Jonathan Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta, Wen-Wen Lin, Liwen Ma, Ming Ge, Zhongyuan Zuo, Lu-Ping Liu, Robert W Levis, Norbert Perrimon, Hugo J Bellen
Publikováno v:
eLife, Vol 11 (2022)
Previously, we described a large collection of Drosophila strains that each carry an artificial exon containing a T2AGAL4 cassette inserted in an intron of a target gene based on CRISPR-mediated homologous recombination. These alleles permit numerous
Externí odkaz:
https://doaj.org/article/21349c0042e4440c9ed944c980a33c8b
Autor:
Felipe Martelli, Natalia H Hernandes, Zhongyuan Zuo, Julia Wang, Ching-On Wong, Nicholas E Karagas, Ute Roessner, Thusita Rupasinghe, Charles Robin, Kartik Venkatachalam, Trent Perry, Philip Batterham, Hugo J Bellen
Publikováno v:
eLife, Vol 11 (2022)
Large-scale insecticide application is a primary weapon in the control of insect pests in agriculture. However, a growing body of evidence indicates that it is contributing to the global decline in population sizes of many beneficial insect species.
Externí odkaz:
https://doaj.org/article/51846748db3143c4a3631663c675f04a
Autor:
Kathleen M Cunningham, Kirstin Maulding, Kai Ruan, Mumine Senturk, Jonathan C Grima, Hyun Sung, Zhongyuan Zuo, Helen Song, Junli Gao, Sandeep Dubey, Jeffrey D Rothstein, Ke Zhang, Hugo J Bellen, Thomas E Lloyd
Publikováno v:
eLife, Vol 9 (2020)
Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified ref(2)P/p62, a ke
Externí odkaz:
https://doaj.org/article/1a36dcfe2f884b73b4686aa681abb4ea
Autor:
Chung-Yang Kao, Mafei Xu, Leiming Wang, Shih-Chieh Lin, Hui-Ju Lee, Lita Duraine, Hugo J Bellen, David S Goldstein, Sophia Y Tsai, Ming-Jer Tsai
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008868 (2020)
Parkinson's disease (PD) is a neurodegenerative disorder featuring progressive loss of midbrain dopaminergic (DA) neurons that leads to motor symptoms. The etiology and pathogenesis of PD are not clear. We found that expression of COUP-TFII, an orpha
Externí odkaz:
https://doaj.org/article/48cc175e61f641c685c04c8ee0bf0d4f
Autor:
Hui Ye, Shamsideen A Ojelade, David Li-Kroeger, Zhongyuan Zuo, Liping Wang, Yarong Li, Jessica YJ Gu, Ulrich Tepass, Avital Adah Rodal, Hugo J Bellen, Joshua M Shulman
Publikováno v:
eLife, Vol 9 (2020)
Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the
Externí odkaz:
https://doaj.org/article/fd37c61344b94ec8a6a73a0cbd9977c7
Autor:
Oguz Kanca, Jonathan Zirin, Jorge Garcia-Marques, Shannon Marie Knight, Donghui Yang-Zhou, Gabriel Amador, Hyunglok Chung, Zhongyuan Zuo, Liwen Ma, Yuchun He, Wen-Wen Lin, Ying Fang, Ming Ge, Shinya Yamamoto, Karen L Schulze, Yanhui Hu, Allan C Spradling, Stephanie E Mohr, Norbert Perrimon, Hugo J Bellen
Publikováno v:
eLife, Vol 8 (2019)
We previously reported a CRISPR-mediated knock-in strategy into introns of Drosophila genes, generating an attP-FRT-SA-T2A-GAL4-polyA-3XP3-EGFP-FRT-attP transgenic library for multiple uses (Lee et al., 2018a). The method relied on double stranded DN
Externí odkaz:
https://doaj.org/article/fbf9b18e540242aa9bc3f668e020beb1
Autor:
David Li-Kroeger, Oguz Kanca, Pei-Tseng Lee, Sierra Cowan, Michael T Lee, Manish Jaiswal, Jose Luis Salazar, Yuchun He, Zhongyuan Zuo, Hugo J Bellen
Publikováno v:
eLife, Vol 7 (2018)
We generated two new genetic tools to efficiently tag genes in Drosophila. The first, Double Header (DH) utilizes intronic MiMIC/CRIMIC insertions to generate artificial exons for GFP mediated protein trapping or T2A-GAL4 gene trapping in vivo based
Externí odkaz:
https://doaj.org/article/38362cb40d434d92b211b0d0b76209e1