Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Hugo H, Knobel"'
Autor:
Rohit Sinha, Khalida A. Lockman, Natalie Z.M. Homer, Edward Bower, Paul Brinkman, Hugo H. Knobel, Jonathan A. Fallowfield, Alan J. Jaap, Peter C. Hayes, John N. Plevris
Publikováno v:
JHEP Reports, Vol 2, Iss 5, Pp 100137- (2020)
Background & aims: Analysis of volatile organic compounds (VOCs) in exhaled breath, ‘volatomics’, provides opportunities for non-invasive biomarker discovery and novel mechanistic insights into a variety of diseases. The purpose of this pilot stu
Externí odkaz:
https://doaj.org/article/c9945b053a8640cda085b65b0ee5ede1
Autor:
Waqar M, Ahmed, Dominic, Fenn, Iain R, White, Breanna, Dixon, Tamara M E, Nijsen, Hugo H, Knobel, Paul, Brinkman, Pouline M P, Van Oort, Marcus J, Schultz, Paul, Dark, Royston, Goodacre, Timothy, Felton, Lieuwe D J, Bos, Stephen J, Fowler
Publikováno v:
BreathDx Consortium 2023, ' Microbial Volatiles as Diagnostic Biomarkers of Bacterial Lung Infection in Mechanically Ventilated Patients ', Clinical Infectious Diseases, vol. 76, no. 6, pp. 1059-1066 . https://doi.org/10.1093/cid/ciac859
BreathDx Consortium, Ahmed, W M, Dark, P, Felton, T, Fowler, S J & Dixon, B 2022, ' Microbial volatiles as diagnostic biomarkers of bacterial lung infection in mechanically ventilated patients ', Clinical infectious diseases . https://doi.org/10.1093/cid/ciac859
BreathDx Consortium, Ahmed, W M, Dark, P, Felton, T, Fowler, S J & Dixon, B 2022, ' Microbial volatiles as diagnostic biomarkers of bacterial lung infection in mechanically ventilated patients ', Clinical infectious diseases . https://doi.org/10.1093/cid/ciac859
Background Early and accurate recognition of respiratory pathogens is crucial to prevent increased risk of mortality in critically ill patients. Microbial-derived volatile organic compounds (mVOCs) in exhaled breath could be used as noninvasive bioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3cef6dc182a46a6d18165e98b7cc1f
https://research.vumc.nl/en/publications/3785b964-3830-4d89-b750-da687c1f0a91
https://research.vumc.nl/en/publications/3785b964-3830-4d89-b750-da687c1f0a91
Autor:
Pouline Mp, van Oort, Tamara M, Nijsen, Iain R, White, Hugo H, Knobel, Timothy, Felton, Nicholas, Rattray, Oluwasola, Lawal, Murtaza, Bulut, Waqar, Ahmed, Antonio, Artigas, Pedro R, Povoa, Ignacio, Martin-Loeches, Hans, Weda, Royston, Goodacre, Marcus J, Schultz, Paul M, Dark, Stephen J, Fowler, Lieuwe D, Bos, Tetyana, Zakharkina
Publikováno v:
BreathDx Consortium, van Oort, P M, Nijsen, T M, White, I R, Knobel, H H, Felton, T, Rattray, N, Lawal, O, Bulut, M, Ahmed, W, Artigas, A, Povoa, P R, Martin-Loeches, I, Weda, H, Goodacre, R, Schultz, M J, Dark, P M, Fowler, S J & Bos, L D 2022, ' Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx) ', Thorax, vol. 77, no. 1, pp. 79-81 . https://doi.org/10.1136/thoraxjnl-2021-217362
Thorax, 77(1):217362, 79-81. BMJ Publishing Group
van Oort, P M, Nijsen, T M, White, I R, Knobel, H H, Felton, T, Rattray, N, Lawal, O, Bulut, M, Ahmed, W, Artigas, A, Povoa, P R, Martin-Loeches, I, Weda, H, Goodacre, R, Schultz, M J, Dark, P M, Fowler, S J & Bos, L D 2022, ' Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx) ', Thorax, vol. 77, no. 1, pp. 79-81 . https://doi.org/10.1136/thoraxjnl-2021-217362
Thorax, 77(1), 79-81. BMJ Publishing Group
Thorax
Thorax, 77(1):217362, 79-81. BMJ Publishing Group
van Oort, P M, Nijsen, T M, White, I R, Knobel, H H, Felton, T, Rattray, N, Lawal, O, Bulut, M, Ahmed, W, Artigas, A, Povoa, P R, Martin-Loeches, I, Weda, H, Goodacre, R, Schultz, M J, Dark, P M, Fowler, S J & Bos, L D 2022, ' Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx) ', Thorax, vol. 77, no. 1, pp. 79-81 . https://doi.org/10.1136/thoraxjnl-2021-217362
Thorax, 77(1), 79-81. BMJ Publishing Group
Thorax
Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA
Autor:
Pouline M. P. van Oort, Sanne de Bruin, Hans Weda, Hugo H. Knobel, Marcus J. Schultz, Lieuwe D. Bos, On Behalf of the MARS Consortium
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 2, p 449 (2017)
The diagnosis of hospital-acquired pneumonia remains challenging. We hypothesized that analysis of volatile organic compounds (VOCs) in exhaled breath could be used to diagnose pneumonia or the presence of pathogens in the respiratory tract in intuba
Externí odkaz:
https://doaj.org/article/562e5aa1d5d143efa71d8f11984b2a46
Autor:
Ruud Johannes Theodorus Soers, Marc A. Benninga, Sofia el Manouni el Hassani, Nanne K. H. de Boer, Tamara M.E. Nijsen, Hans Weda, Hendrik J. Niemarkt, Hugo H. Knobel, Tim G. J. de Meij, Daniel J. C. Berkhout
Publikováno v:
Metabolomics, 16(10):112
Metabolomics, 16(10):112. Springer New York
Metabolomics
el Manouni el Hassani, S, Soers, R J, Berkhout, D J C, Niemarkt, H J, Weda, H, Nijsen, T, Benninga, M A, de Boer, N K H, de Meij, T G J & Knobel, H H 2020, ' Optimized sample preparation for fecal volatile organic compound analysis by gas chromatography–mass spectrometry ', Metabolomics, vol. 16, no. 10, 112 . https://doi.org/10.1007/s11306-020-01735-6
Metabolomics, 16(10):112. Springer New York
Metabolomics
el Manouni el Hassani, S, Soers, R J, Berkhout, D J C, Niemarkt, H J, Weda, H, Nijsen, T, Benninga, M A, de Boer, N K H, de Meij, T G J & Knobel, H H 2020, ' Optimized sample preparation for fecal volatile organic compound analysis by gas chromatography–mass spectrometry ', Metabolomics, vol. 16, no. 10, 112 . https://doi.org/10.1007/s11306-020-01735-6
Introduction Headspace gas chromatography–mass spectrometry (HS-GC–MS) is widely considered the gold standard of quantitative fecal VOC analysis. However, guidelines providing general recommendations for bioanalytical method application in resear
Autor:
Hugo H. Knobel, Stephen J. Fowler, Craig E. Wheelock, Paolo Montuschi, Peter J. Sterk, Cristina Gómez, Teunis J. Vink, Anke H. Maitland-van der Zee, Sven-Erik Dahlén, Waqar Ahmed, Tamara M.E. Nijsen, Hans Weda, Susanne J. H. Vijverberg, Richard G. Knowles, Paul Brinkman
Publikováno v:
U-BIOPRED Study Group 2019, ' Exhaled Volatile Organic Compounds as Markers for Medication Use in Asthma ', The European respiratory journal . https://doi.org/10.1183/13993003.00544-2019
European respiratory journal, 55(2):1900544. European Respiratory Society
European respiratory journal, 55(2):1900544. European Respiratory Society
IntroductionAsthma is a heterogeneous condition, characterised by chronic inflammation of the airways, typically managed with inhaled bronchodilators and corticosteroids. In the case of uncontrolled asthma, oral corticosteroids (OCSs) are often presc
Autor:
Hugo H. Knobel, Rohit A. Sinha, Jonathan A. Fallowfield, John N. Plevris, K. A. Lockman, Peter C. Hayes, Edward K M Bower, Paul Brinkman, Alan Jaap, Natalie Z.M. Homer
Publikováno v:
JHEP Reports
Sinha, R, Lockman, K A, Homer, N, Bower, E, Brinkman, P, Knobel, H H, Fallowfield, J, Jaap, A J, Hayes, P & Plevris, J N 2020, ' Volatomic analysis identifies compounds that can stratify non-alcoholic fatty liver disease ', JHEP Reports . https://doi.org/10.1016/j.jhepr.2020.100137
JHEP Reports, Vol 2, Iss 5, Pp 100137-(2020)
Sinha, R, Lockman, K A, Homer, N, Bower, E, Brinkman, P, Knobel, H H, Fallowfield, J, Jaap, A J, Hayes, P & Plevris, J N 2020, ' Volatomic analysis identifies compounds that can stratify non-alcoholic fatty liver disease ', JHEP Reports . https://doi.org/10.1016/j.jhepr.2020.100137
JHEP Reports, Vol 2, Iss 5, Pp 100137-(2020)
Background & aims Analysis of volatile organic compounds (VOCs) in exhaled breath, ‘volatomics’, provides opportunities for non-invasive biomarker discovery and novel mechanistic insights into a variety of diseases. The purpose of this pilot stud
Publikováno v:
Journal of Luminescence, 218:116845. Elsevier
Irradiation of Lumogen Red 305 (3) in ethyl acetate with intense blue LED light led to very slow bleaching, showing a high photochemical stability. However, irradiation in ethanol led to the formation of a low yield product in which one of the phenox
Autor:
Stephen J. Fowler, Craig E. Wheelock, Hugo H. Knobel, Paolo Montuschi, Cristina Gómez, Peter J. Sterk, Waqar Ahmed, Hans Weda, Tamara M.E. Nijsen, Richard G. Knowles, Teunis J. Vink, Anke H. Maitland-van der Zee, Paul Brinkman, Sven-Erik Dahlén, Susanne J. H. Vijverberg
Publikováno v:
Monitoring Airway Disease.
Autor:
Fred Verhoeckx, Hugo H. Knobel, Alan James Davie, Ruud J.A. Steenwelle, Ron Steijvers, Tamara M.E. Nijsen, Stephen J. Fowler, Augustinus J.H.M. Rijnders, Royston Goodacre, Waqar Ahmed
Publikováno v:
Measurement science and technology, 31(3):035103. Institute of Physics (IOP)
Measurement Science and Technology
Measurement Science and Technology
Exhaled breath contains thousands of volatile organic compounds (VOCs), some of which have been associated with respiratory disease. We describe a sensor device with an array of eight polymer-coated piezoelectric micro-cantilevers (two of each PAA, P