Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Hugo Gagnon"'
Autor:
Elmira Shajari, David Gagné, Mandy Malick, Patricia Roy, Jean-François Noël, Hugo Gagnon, Marie A. Brunet, Maxime Delisle, François-Michel Boisvert, Jean-François Beaulieu
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 333 (2024)
Inflammatory bowel disease (IBD) flare-ups exhibit symptoms that are similar to other diseases and conditions, making diagnosis and treatment complicated. Currently, the gold standard for diagnosing and monitoring IBD is colonoscopy and biopsy, which
Externí odkaz:
https://doaj.org/article/4a8ec7ba83a9424b827288a9717dcb4f
Autor:
David Gagné, Elmira Shajari, Marie-Pier Thibault, Jean-François Noël, François-Michel Boisvert, Corentin Babakissa, Emile Levy, Hugo Gagnon, Marie A. Brunet, David Grynspan, Emanuela Ferretti, Valérie Bertelle, Jean-François Beaulieu
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11601 (2022)
Necrotizing enterocolitis (NEC) is a life-threatening condition for premature infants in neonatal intensive care units. Finding indicators that can predict NEC development before symptoms appear would provide more time to apply targeted interventions
Externí odkaz:
https://doaj.org/article/b11b26c133d84df583daf544f86db726
Autor:
Martin Houde, Adel Schwertani, Hanène Touil, Louisane Desbiens, Otman Sarrhini, Roger Lecomte, Martin Lepage, Hugo Gagnon, Shinji Takai, Gunnar Pejler, Danielle Jacques, Fernand Gobeil, Robert Day, Pedro D’Orléans-Juste
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Chymase, a mast cell serine protease involved in the generation of multiple cardiovascular factors, such as angiotensin II and endothelin-1 (ET-1), is elevated and participates in tissue degeneration after permanent myocardial infarction (PMI). Anest
Externí odkaz:
https://doaj.org/article/7ecc202a5ad84f19a487e143256394bc
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61557 (2013)
The proprotein convertase 1/3 (PC1/3) is an important post-translational processing enzyme for the activation of precursor proteins within the regulated secretory pathway. Well characterized for its role in the neural and endocrine systems, we recent
Externí odkaz:
https://doaj.org/article/716b168afcf24c2eaa0c720118ccba8a
Autor:
Kévin Ly, Hugo Gagnon, Pauline Navals, Yves L. Dory, Anna Kwiatkowska, Monika A Lewandowska-Goch, Adam Prahl, Teresa Łepek, Robert Day
Publikováno v:
ACS Med Chem Lett
Furin plays an important role in various pathological states, especially in bacterial and viral infections A detailed understanding of the structural requirements for inhibitors targeting this enzyme is crucial to develop new therapeutic strategies i
Autor:
Robert Day, Modou Lo, Hugo Gagnon, Laurence Vincent, Catherine Lapointe, Shinji Takai, Gunnar Pejler, Pedro D'Orléans-Juste
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:213-221
Mouse mast cell protease 4 (mMCP-4), the murine functional analog to the human chymase, is a serine protease synthesized and stored in mast cell secretory granules. Our previous studies reported physiologic and pathologic roles for mMCP-4 in the matu
Autor:
Hugo Gagnon, Stephen Naylor, Paul E. Pace, Alexander V. Peskin, P Richard J. Wagner, Klaus Klarskov, Grace Kouakou Ahuie
Publikováno v:
Rapid Communications in Mass Spectrometry. 34
Rationale Oxidative stress is an imbalance between reactive free radical oxygen species and antioxidant defenses. Its consequences can lead to numerous pathologies. Regulating oxidative stress is the complex interplay between antioxidant recycling an
An efficient application of Bayesian optimization to an industrial MDO framework for aircraft design
Publikováno v:
AIAA AVIATION 2020 FORUM
AIAA AVIATION 2020 FORUM, Jun 2020, Inconnu, United States. ⟨10.2514/6.2020-3152⟩
AIAA AVIATION 2020 FORUM, Jun 2020, Inconnu, United States. ⟨10.2514/6.2020-3152⟩
The multi-level, multi-disciplinary and multi-fidelity optimization framework developed at Bombardier Aviation has shown great results to explore efficient and competitive aircraft configurations. This optimization framework has been developed within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc936719786ae16046ef8901a06c7df
https://oatao.univ-toulouse.fr/26105/
https://oatao.univ-toulouse.fr/26105/
Autor:
Vicky H. Bhagat, Matthew D’Alessandro, Shyam Sundhar Bale, Nima Saeidi, John M. Asara, Korkut Uygun, Hugo Gagnon, Martin L. Yarmush, Gautham V. Sridharan
Publikováno v:
TECHNOLOGY. :139-184
Morbidly obese patients often elect for Roux-en-Y gastric bypass (RYGB), a form of bariatric surgery that triggers a remarkable 30% reduction in excess body weight and reversal of insulin resistance for those who are type II diabetic. A more complete
Autor:
J. Richard Wagner, Grace Ahuié Kouakou, Stephen Naylor, Hugo Gagnon, Klaus Klarskov, Vincent Lacasse
Publikováno v:
Free radical biologymedicine. 141
Ascorbic acid (vitamin C) plays a significant role in the prevention of oxidative stress. In this process, ascorbate is oxidized to dehydroascorbate (DHA). We have investigated the impact of DHA on peptide/protein intramolecular disulfide formation a