Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity.

Autor: Hugo G Hilton, Nimrod D Rubinstein, Peter Janki, Andrea T Ireland, Nicholas Bernstein, Nicole L Fong, Kevin M Wright, Megan Smith, David Finkle, Baby Martin-McNulty, Margaret Roy, Denise M Imai, Vladimir Jojic, Rochelle Buffenstein

Publikováno v: PLoS Biology, Vol 17, Iss 11, p e3000528 (2019)

The immune system comprises a complex network of specialized cells that protects against infection, eliminates cancerous cells, and regulates tissue repair, thus serving a critical role in homeostasis, health span, and life span. The subterranean-dwe

Externí odkaz: https://doaj.org/article/7ccaa2b5062f41649723a8e1c83b849e

Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans.

Autor: Paul J Norman, Jill A Hollenbach, Neda Nemat-Gorgani, Lisbeth A Guethlein, Hugo G Hilton, Marcelo J Pando, Kwadwo A Koram, Eleanor M Riley, Laurent Abi-Rached, Peter Parham

Publikováno v: PLoS Genetics, Vol 9, Iss 10, p e1003938 (2013)

Interactions between HLA class I molecules and killer-cell immunoglobulin-like receptors (KIR) control natural killer cell (NK) functions in immunity and reproduction. Encoded by genes on different chromosomes, these polymorphic ligands and receptors

Externí odkaz: https://doaj.org/article/3503166ed6d044509432b12c89929605

Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors

Autor: Daniel M. Davis, Khodor S. Hazime, Charlotte Barthen, David Williamson, Philippa R. Kennedy, Joshua Cumming, Kevin B. Stacey, Hugo G. Hilton, William T. E. Pitkeathly, Peter Parham, Mary Carrington

Publikováno v: Kennedy, P, Barthen, C, Williamson, D, Pitkeathly, W, Hazime, K, Cumming, J, Stacey, K, Hilton, H G, Carrington, M, Parham, P & Davis, D M 2019, ' Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors ', Science Signaling . https://doi.org/10.1126/scisignal.aaw9252
Sci Signal

Genetic diversity in human natural killer (NK) cell receptors is linked to resistance and susceptibility to many diseases, but the underlying mechanisms remain unclear. The effect of this diversity on the nanoscale organization of killer cell immunog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9b2b75f4b6971ac11a769a9d056d2c
https://doi.org/10.1126/scisignal.aaw9252

Missing or altered self: human NK cell receptors that recognize HLA-C

Autor: Peter Parham, Hugo G. Hilton

Publikováno v: Immunogenetics. 69:567-579

Natural killer (NK) cells are fast-acting and versatile lymphocytes that are critical effectors of innate immunity, adaptive immunity, and placental development. Controlling NK cell function are the interactions between killer-cell immunoglobulin-lik

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b155c834f4db418ea513a8c3ec3a05b
https://doi.org/10.1007/s00251-017-1001-y

Two Orangutan Species Have Evolved Different KIR Alleles and Haplotypes

Autor: Paul Norman, Ronald E. Bontrop, Hugo G. Hilton, Lisbeth A. Guethlein, Laurent Abi-Rached, Natasja G. de Groot, Corinne M. C. Heijmans, Farbod Babrzadeh, Peter Parham

Publikováno v: The Journal of Immunology. 198:3157-3169

The immune and reproductive functions of human NK cells are regulated by interactions of the C1 and C2 epitopes of HLA-C with C1-specific and C2-specific lineage III killer cell Ig-like receptors (KIR). This rapidly evolving and diverse system of lig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e8d2d67a2caec2dde0a8bc0da54598e
https://doi.org/10.4049/jimmunol.1602163