Výsledky vyhledávání - "Hugo D. Lujan"

Using Protozoan Surface Proteins for Effective Oral Vaccination

Autor: Marianela C. Serradell, Hugo D. Lujan, Lucía Lara Rupil

Publikováno v: Trends in Parasitology. 36:7-10

The Global Vaccine Action Plan of the World Health Organization (WHO) calls for nonsyringe delivery mechanisms, thermostable vaccines, and new bioprocessing technologies as priority research areas. Here we discuss the use of protozoan surface protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7092230479fd2abaf1d3646f867c8d
https://doi.org/10.1016/j.pt.2019.07.004

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A thermostable oral SARS-CoV-2 vaccine induces mucosal and protective immunity

Autor: Hugo D. Lujan, Cecilia Molina, Lucas Lujan, Bertrand Bellier, Alicia Saura, David Klatzmann

Publikováno v: Bellier, Bertrand, Saura, Alicia ORCID: https://orcid.org/0000-0003-1537-506X , Luján, Lucas A. ORCID: https://orcid.org/0000-0003-4235-4301 , Molina, Cecilia R., Luján, Hugo Daniel ORCID: https://orcid.org/0000-0002-3797-8315 and Klatzmann, David (2022) A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity. Frontiers in Immunology, 13. ISSN 1664-3224

An ideal protective vaccine against SARS-CoV-2 should not only be effective in preventing disease, but also in preventing virus transmission. It should also be well accepted by the population and have a simple logistic chain. To fulfill these criteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a952a8c207cccf1f630f804032693693
https://doi.org/10.1101/2021.09.09.459634

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Unveiling the immune infiltrate modulation in cancer and response to immunotherapy by MIXTURE—an enhanced deconvolution method

Autor: Matías Miranda, María Romina Girotti, Mónica Balzarini, Elmer Andrés Fernández, Hugo D. Lujan, Gabriel A. Rabinovich, Darío Rocha, Yamil Damián Mahmoud, Florencia Veigas, Joaquín Pedro Merlo

Publikováno v: Brief Bioinform

The accurate quantification of tumor-infiltrating immune cells turns crucial to uncover their role in tumor immune escape, to determine patient prognosis and to predict response to immune checkpoint blockade. Current state-of-the-art methods that qua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5aeb3a905071524c82a5701f1a5d5e4
https://doi.org/10.1093/bib/bbaa317

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Akademický článek

Tunneling Nanotube-like Structures in Giardia duodenalis

Autor: Victor Midlej, Albano H. Tenaglia, Hugo D. Luján, Wanderley de Souza

Publikováno v: Cells, Vol 13, Iss 18, p 1538 (2024)

Giardia doudenalis (lamblia, intestinalis) is a protozoan parasite that inhabits the lumen of the upper small intestine of vertebrates, causing chronic abdominal pains and severe diarrhea, symptoms of giardiasis, a persistent and recurrent infection.

Externí odkaz: https://doaj.org/article/4ff3d2e97d3e498087fe654734ae177c

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Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia

Autor: César G. Prucca, Hugo D. Lujan, Pedro Gabriel Carranza, Staffan G. Svärd, Pablo Rubén Gargantini, Alicia Saura, Alessandro Torri

Publikováno v: The International Journal of Biochemistry & Cell Biology. 81:32-43

During evolution, parasitic microorganisms have faced the challenges of adapting to different environments to colonize a variety of hosts. Giardia lamblia, a common cause of intestinal disease, has developed fascinating strategies to adapt both outsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28065eb195f72bb194381b2d6aef59f1
https://doi.org/10.1016/j.biocel.2016.10.010

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Characterization of proteolytic activities of Giardia lamblia with the ability to cleave His-tagged N-terminal sequences

Autor: Pedro Gutiérrez-Castrellón, Cynthia Fernández-Lainez, Itzhel García-Torres, Sergio Enríquez-Flores, Augusto González-Canto, Roberto Hernández, Alfonso Olivos-García, José Ignacio de la Mora-de la Mora, Hugo D. Lujan, Gabriel López-Velázquez

Giardia lamblia is one of the most common protozoan infectious agents in the world and is responsible for diarrheal disease and chronic postinfectious illness. During the host-parasite interaction, proteases are important molecules related to virulen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f04e1ee2ec16b73141b7f3b677a900
https://www.sciencedirect.com/science/article/pii/S0166685118301695?via=ihub

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Cytokines, Antibodies, and Histopathological Profiles during Giardia Infection and Variant-Specific Surface Protein-Based Vaccination

Autor: Alicia Saura, Lucía Lara Rupil, Hugo D. Lujan, Sergio Rafael Oms, Luciana Berod, Marianela C. Serradell, Tim Sparwasser, Pablo Rubén Gargantini

Publikováno v: Infection and immunity
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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Giardiasis is one of the most common human intestinal diseases worldwide. Several experimental animal models have been used to evaluate Giardia infections, with gerbils (Meriones unguiculatus) being the most valuable model due to their high susceptib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de6872c84f102e7346e0a062b53b30f
https://hdl.handle.net/10033/621403

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Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses

Autor: Daniel Barkan, Nils Lycke, Philipp Stüve, Maria Virginia Gentilini, Mariana Andrea Martina, Maxine Swallow, Judith Bartel, Luciana Berod, Yvette van Kooyk, Hakan Kalay, Lis Noelia Velasquez, Hugo D. Lujan, Tim Sparwasser

Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, 9(MAR):471. Frontiers Media S.A.
Frontiers in Immunology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Velasquez, L N, Stüve, P, Gentilini, M V, Swallow, M, Bartel, J, Lycke, N Y, Barkan, D, Martina, M, Lujan, H D, Kalay, H, van Kooyk, Y, Sparwasser, T D & Berod, L 2018, ' Targeting Mycobacterium tuberculosis antigens to dendritic cells via the DC-specific-ICAM3-grabbing-nonintegrin receptor induces strong T-helper 1 immune responses ', Frontiers in Immunology, vol. 9, no. MAR, 471, pp. 471 . https://doi.org/10.3389/fimmu.2018.00471, https://doi.org/10.3389/fimmu.2018.00471

Tuberculosis remains a major global health problem and efforts to develop a more effective vaccine have been unsuccessful so far. Targeting antigens (Ags) to dendritic cells (DCs) in vivo has emerged as a new promising vaccine strategy. In this appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4692dee5f49d368de4615627fb69a925
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00471/full

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