Výsledky vyhledávání - "Hugo D Meiring"

Akademický článek

Vaccine antigens modulate the innate response of monocytes to Al(OH)3.

Autor: Sietske Kooijman, Jolanda Brummelman, Cécile A C M van Els, Fabio Marino, Albert J R Heck, Elly van Riet, Bernard Metz, Gideon F A Kersten, Jeroen L A Pennings, Hugo D Meiring

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0197885 (2018)

Aluminum-based adjuvants have widely been used in human vaccines since 1926. In the absence of antigens, aluminum-based adjuvants can initiate the inflammatory preparedness of innate cells, yet the impact of antigens on this response has not been inv

Externí odkaz: https://doaj.org/article/6ad0b8e6c56a4ef89898621dfb1da13b

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Akademický článek

Measles virus epitope presentation by HLA: novel insights into epitope selection, dominance and microvariation

Autor: Ingrid eSchellens, Hugo D Meiring, Ilka eHoof, Sanne eSpijkers, Martien C.M. Poelen, Jacqueline A.M. van Gaans-van den Brink, Ana I Costa, Harry eVennema, Can eKesmir, Debbie eVan Baarle, Cecile A.C.M. Van Els

Publikováno v: Frontiers in Immunology, Vol 6 (2015)

Immunity to infections with Measles Virus (MV) can involve vigorous HLA class I restricted CD8+ cytotoxic T cell (CTL) responses. MV, albeit regarded monotypic, is known to undergo molecular evolution across its RNA genome. To address which regions o

Externí odkaz: https://doaj.org/article/838b3325e52047f9b46e490f5bee6701

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Akademický článek

Comprehensive Analysis of the Naturally Processed Peptide Repertoire: Differences between HLA-A and B in the Immunopeptidome.

Autor: Ingrid M M Schellens, Ilka Hoof, Hugo D Meiring, Sanne N M Spijkers, Martien C M Poelen, Jacqueline A M van Gaans-van den Brink, Kees van der Poel, Ana I Costa, Cecile A C M van Els, Debbie van Baarle, Can Kesmir

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0136417 (2015)

The cytotoxic T cell (CTL) response is determined by the peptide repertoire presented by the HLA class I molecules of an individual. We performed an in-depth analysis of the peptide repertoire presented by a broad panel of common HLA class I molecule

Externí odkaz: https://doaj.org/article/e134428abef34369b0b2c2e254b15cbf

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Akademický článek

Transcriptome and proteome analysis of innate immune responses to inactivated Leptospira and bivalent Leptospira vaccines in canine 030-D cells

Autor: Andreja Novak, Jeroen L. A. Pennings, Larissa van der Maas, Hugo D. Meiring, Irene Ludwig, Saertje Verkoeijen, Victor Rutten, Femke Broere, Arjen Sloots

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Mandatory potency testing of Leptospira vaccine batches relies partially on in vivo procedures, requiring large numbers of laboratory animals. Cell-based assays could replace in vivo tests for vaccine quality control if biomarkers indicative

Externí odkaz: https://doaj.org/article/e46659c5d0b84495bccbdc701f0cea3f

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Common Reference-Based Tandem Mass Tag Multiplexing for the Relative Quantification of Peptides: Design and Application to Degradome Analysis of Diphtheria Toxoid

Autor: Hugo D. Meiring, Madelief A van Veen, Gideon F.A. Kersten, Wim Jiskoot, Bernard Metz, Thomas J M Michiels

Publikováno v: Journal of the American Society for Mass Spectrometry
Journal of the American Society for Mass Spectrometry, 32(6), 1490-1497

Currently, animal tests are being used to confirm the potency and lack of toxicity of toxoid vaccines. In a consistency approach, animal tests could be replaced if production consistency (compared to known good products) can be proven in a panel of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96a7e7c6369fa71c62efaf9d646cb2f
http://europepmc.org/articles/PMC8176455

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Novel Formaldehyde-Induced Modifications of Lysine Residue Pairs in Peptides and Proteins: Identification and Relevance to Vaccine Development

Autor: Hugo D. Meiring, Thomas J M Michiels, Christian Schöneich, Gideon F.A. Kersten, Martin R.J. Hamzink, Bernard Metz, Wim Jiskoot

Publikováno v: Molecular Pharmaceutics. 17:4375-4385

Formaldehyde-inactivated toxoid vaccines have been in use for almost a century. Despite formaldehyde's deceptively simple structure, its reactions with proteins are complex. Treatment of immunogenic proteins with aqueous formaldehyde results in heter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5ca201472bde808daab443f88ace1d
https://doi.org/10.1021/acs.molpharmaceut.0c00851

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Nanoflow LC-MS Method Allowing In-Depth Characterization of Natural Heterogeneity of Complex Bacterial Lipopolysaccharides

Autor: Peter van der Ley, Elder Pupo, Hugo D. Meiring

Publikováno v: Analytical chemistry. 93(48)

The variable modification of the outer membrane lipopolysaccharide (LPS) in Gram-negative bacteria contributes to bacterial pathogenesis through various mechanisms, including the development of antibiotic resistance and evasion of the immune response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272f04cf7af5b5e5341de1e59c720b59
https://pubmed.ncbi.nlm.nih.gov/34807566

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Non-linear in cis-spliced bacterial MHC class II epitopes are formed in human monocyte-derived dendritic cells and are recognized by human CD4+ T cells

Autor: Hugo D. Meiring, Betsy A.J. Kuipers, Jacqueline A.M. van Gaans-van den Brink, Martien C.M. Poelen, Ad P.J.M. de Jong, Albert J.R. Heck, Cecile A.C.M. van Els

Publikováno v: Molecular Immunology. 150:24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb8f0e9225c04f5aab32dc3c9afedcb4
https://doi.org/10.1016/j.molimm.2022.05.083

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Novel mumps virus epitopes reveal robust cytotoxic T cell responses after natural infection but not after vaccination

Autor: Cécile A. C. M. van Els, Maarten E. Emmelot, Hugo D. Meiring, Patricia Kaaijk, Jelle de Wit

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)

Mumps is nowadays re-emerging despite vaccination. The contribution of T cell immunity to protection against mumps has not been clearly defined. Previously, we described a set of 41 peptides that were eluted from human leukocyte antigen (HLA) class I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab8c6a10ec118bd6cbcd449034019a7
https://doi.org/10.1038/s41598-021-92926-1

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Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine

Autor: Robin H.G.A. van den Biggelaar, Larissa van der Maas, Willem van Eden, Christine A. Jansen, Jeroen L. A. Pennings, Hugo D. Meiring, Victor P.M.G. Rutten

Publikováno v: Scientific Reports, 11(1)
Scientific Reports, 11(1). NLM (Medline)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports 11 (2021) 1

Inactivated poultry vaccines are subject to routine potency testing for batch release, requiring large numbers of animals. The replacement of in vivo tests for cell-based alternatives can be facilitated by the identification of biomarkers for vaccine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b1bad1e7be157494dfb7cc2c67f3b7
https://doi.org/10.1038/s41598-021-89810-3

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