Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hugo D, Luján"'
Publikováno v:
Cells, Vol 13, Iss 18, p 1538 (2024)
Giardia doudenalis (lamblia, intestinalis) is a protozoan parasite that inhabits the lumen of the upper small intestine of vertebrates, causing chronic abdominal pains and severe diarrhea, symptoms of giardiasis, a persistent and recurrent infection.
Externí odkaz:
https://doaj.org/article/4ff3d2e97d3e498087fe654734ae177c
Autor:
Albano H. Tenaglia, Lucas A. Luján, Diego N. Ríos, Cecilia R. Molina, Victor Midlej, Paula A. Iribarren, María A. Berazategui, Alessandro Torri, Alicia Saura, Damián O. Peralta, Macarena Rodríguez-Walker, Elmer A. Fernández, Juan P. Petiti, Marianela C. Serradell, Pablo R. Gargantini, Tim Sparwasser, Vanina E. Alvarez, Wanderley de Souza, Hugo D. Luján
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The genomes of most protozoa encode families of variant surface antigens. In some parasitic microorganisms, it has been demonstrated that mutually exclusive changes in the expression of these antigens allow parasites to evade the host’s im
Externí odkaz:
https://doaj.org/article/d049b6259f2c4206b06f3bf7ce1aad2b
Autor:
Guadalupe Nibeyro, Veronica Baronetto, Juan I. Folco, Pablo Pastore, Maria Romina Girotti, Laura Prato, Gabriel Morón, Hugo D. Luján, Elmer A. Fernández
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionIdentification of tumor specific neoantigen (TSN) immunogenicity is crucial to develop peptide/mRNA based anti-tumoral vaccines and/or adoptive T-cell immunotherapies; thus, accurate in-silico classification/prioritization proves critical
Externí odkaz:
https://doaj.org/article/ad5d77a1007d48128d7b7a79f122f733
Autor:
Bertrand Bellier, Alicia Saura, Lucas A. Luján, Cecilia R. Molina, Hugo D. Luján, David Klatzmann
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
An ideal protective vaccine against SARS-CoV-2 should not only be effective in preventing disease, but also in preventing virus transmission. It should also be well accepted by the population and have a simple logistic chain. To fulfill these criteri
Externí odkaz:
https://doaj.org/article/358d2206ce0f4133aa9e7ac0a3412f92
Autor:
Marianela C. Serradell, Lucía L. Rupil, Román A. Martino, César G. Prucca, Pedro G. Carranza, Alicia Saura, Elmer A. Fernández, Pablo R. Gargantini, Albano H. Tenaglia, Juan P. Petiti, Renata R. Tonelli, Nicolás Reinoso-Vizcaino, José Echenique, Luciana Berod, Eliane Piaggio, Bertrand Bellier, Tim Sparwasser, David Klatzmann, Hugo D. Luján
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to
Externí odkaz:
https://doaj.org/article/e1faa7844c394e018f3b0bfaf2625985
Autor:
Albano H. Tenaglia, Lucas A. Luján, Diego N. Ríos, Victor Midlej, Paula A. Iribarren, Cecilia R. Molina, M. Agustina Berazategui, Alessandro Torri, Alicia Saura, Damián O. Peralta, Macarena Rodríguez-Walker, Elmer A. Fernández, Juan P. Petiti, Marianela C. Serradell, Pablo R. Gargantini, Vanina E. Alvarez, Wanderley de Souza, Hugo D. Luján
The genomes of most protozoa encode families of variant surface antigens, whose mutually exclusive changes in expression allow parasitic microorganisms to evade the host immune response1,2. It is widely assumed that antigenic variation in protozoan p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3971990d6909c17157bee4c13c6a92ca
https://doi.org/10.1101/2022.06.21.497077
https://doi.org/10.1101/2022.06.21.497077
Autor:
Guadalupe Nibeyro, Romina Girotti, Laura Prato, Gabriel Moron, Hugo D. Luján, Elmer A. Fernandez
Tumor-specific antigens emerging through somatic genomic rearrangements, known as neoantigens, play a critical role in current anticancer immunotherapy. They may or may not elicit an immune response when presented on the tumor cell surface bound to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::035e9bf0c8ba04dd2defae4059ba12ee
https://doi.org/10.1101/2022.03.14.484285
https://doi.org/10.1101/2022.03.14.484285
Autor:
Macarena Rodríguez-Walker, Cecilia R. Molina, Lucas A. Luján, Alicia Saura, Verónica M. Baronetto, Jon Jerlström-Hultqvist, Staffan G. Svärd, Elmer A. Fernández, Hugo D. Luján
Giardia lamblia encode several families of cysteine-rich proteins. Among these families are the Variant-specific Surface Proteins (VSPs), which are involved in the process of antigenic variation. In addition to VSPs, other Cys-rich proteins have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e29ef496e927fed7e71e0cedb52071ce
https://doi.org/10.1101/2022.03.07.483299
https://doi.org/10.1101/2022.03.07.483299
Autor:
Sascha, Krakovka, Farahnaz, Ranjbarian, Lucas A, Luján, Alicia, Saura, Nicolai B, Larsen, Alejandro, Jiménez-González, Anna, Reggenti, Hugo D, Luján, Staffan G, Svärd, Anders, Hofer
Publikováno v:
The Journal of biological chemistry. 298(6)
Giardiasis is a diarrheal disease caused by the unicellular parasite Giardia intestinalis, for which metronidazole is the main treatment option. The parasite is dependent on exogenous deoxyribonucleosides for DNA replication and thus is also potentia
Publikováno v:
Medicina. 79(Spec 6/1)
The international spread of infectious diseases is a global problem of health security. Vaccination is one of the most successful and profitable health interventions. Oral immunization has significant advantages over the widely used parental vaccines