Výsledky vyhledávání - "Hugo Alejandro Garro"

Collection of alkenylcoumarin derivatives as Taq DNA polymerase inhibitors: SAR and in silico simulations

Autor: Lucas J. Gutierrez, Hugo Alejandro Garro, Carlos R. Pungitore, Ezequiel Bruna-Haupt

Publikováno v: Medicinal Chemistry Research. 27:1432-1442

Using a feasible method, we generated a small focused library of structurally related alkenylcoumarins. These compounds were evaluated as potential antitumoral agents against Taq DNA polymerase. 6-(pent-4-enyloxy)-coumarin (7) IC50 = 48.33 ± 2.85 μ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5210f648122e6c86a56ac21ec56d34d9
https://doi.org/10.1007/s00044-018-2160-6

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Autor: Hugo Alejandro Garro, Carlos R. Pungitore

Publikováno v: Current drug targets. 20(1)

Background:The discovery of new chemotherapeutic agents still remains a continuous goal to achieve. DNA polymerases and topoisomerases act in nucleic acids metabolism modulating different processes like replication, mitosis, damage repair, DNA topolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb49932bbc73044fdf5fe96be216303
https://pubmed.ncbi.nlm.nih.gov/29697027

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Coumarins as potential inhibitors of DNA polymerases and reverse transcriptases. searching new antiretroviral and antitumoral drugs

Autor: Hugo Alejandro Garro, Carlos R. Pungitore

Human Immunodeficiency Virus (HIV) is the viral agent of Acquired Immunodeficiency Syndrome (AIDS), and at present, there is no effective vaccine against HIV. Reverse Transcriptase (RT) is an essential enzyme for retroviral replication, such as HIV a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e3e7951526c27b3f95c532b73818f8
http://www.eurekaselect.com/133277/article

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A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase

Autor: Carlos E. Tonn, Víctor S. Martín, Celina García, Carlos R. Pungitore, Hugo Alejandro Garro

Publikováno v: Bioorganicmedicinal chemistry letters. 25(4)

DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bf101ab5dccbb84c5015499e9db012
https://pubmed.ncbi.nlm.nih.gov/25582597

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Cytotoxic and Antitumor Activity of some Coumarin Derivatives

Autor: Guillermo Federico Reta, Osvaldo J. Donadel, Hugo Alejandro Garro, Carlos R. Pungitore

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Several natural and synthetic coumarins were assayed against different cancer cell lines. Four of them have shown cytotoxicity against a panel of three human solid tumor cell lines (HeLa, T-47D, and WiDr) and a clearly activity/hydrophobicity relatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9530b3840832dccacb177bbb52679a
https://doi.org/10.1177/1934578x1601100926

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In silico study of the inhibition of DNA polymerase by a novel catalpol derivative

Autor: Osvaldo A. Martin, Hugo Alejandro Garro, Marcela B. Kurina Sanz, Carlos R. Pungitore, Carlos E. Tonn

Publikováno v: Journal of molecular modeling. 17(10)

In this work, a novel catalpol derivative (6,10,2′,6′-tetraacetyl-O-catalpol), which was previously obtained by our group and shown experimentally to inhibit a type of Taq DNA polymerase, was studied in silico. Studies of the interaction of 6,10,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d925e778debc0bf1540bc7752a0a1cf
https://pubmed.ncbi.nlm.nih.gov/21229371

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